Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests

ABSTRACT

This invention pertains to methods for controlling invertebrate pests comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I) wherein B is O, S or NR 1 ; J is a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R 5 ; and R 1 , R 2 , R 4 , R 5  and n are as defined in the disclosure. This invention also pertains to certain compounds of Formula (I) and compositions for controlling invertebrate pests comprising a biologically effective amount of a compound of Formula (I) and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents and optionally further comprising an effective amount of at least one additional biologically active compound or agent

BACKGROUND OF THE INVENTION

This invention relates to certain iminobenzoxazines, iminobenzthiazines and iminoquinazolines, their N-oxides, salts and compositions suitable for agronomic and nonagronomic uses, including those uses listed below, and a method of their use for controlling invertebrate pests in both agronomic and nonagronomic environments.

The control of invertebrate pests is extremely important in achieving high crop efficiency. Damage by invertebrate pests to growing and stored agronomic crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. The control of invertebrate pests in forestry, greenhouse crops, ornamentals, nursery crops, stored food and fiber products, livestock, household, and public and animal health is also important. Many products are commercially available for these purposes, but the need continues for new compounds that are more effective, less costly, less toxic, environmentally safer or have different modes of action.

NL 9202078 discloses N-acyl anthranilic acid derivatives of Formula i as insecticides

wherein, inter alia, X is a direct bond; Y is H or C₁–C₆ alkyl; Z is NH₂, NH(C₁–C₃ alkyl) or N(C₁–₃ alkyl)₂; and R¹ through R⁹ are independently H, halogen, C₁–C₆ alkyl, phenyl, hydroxy, C₁–C₆ alkoxy or C₁–C₇ acyloxy.

WO 00/31082 discloses pyrimidin-4-enamines of Formula ii as fungicides

wherein, inter alia, A is a fused benzene ring; R¹, R² and R³ are H, halogen, optionally substituted alkyl, alkenyl or alkynyl; R⁴ is optionally substituted phenyl; R⁵ is optionally substituted alkyl, alkenyl or alkynyl; and R⁶ is H or optionally substituted alkyl, alkenyl or alkynyl.

SUMMARY OF THE INVENTION

This invention pertains to a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt of the compound (e.g., as a composition described herein)

wherein

-   -   B is O, S or NR¹;     -   J is a phenyl ring, a naphthyl ring system, a 5- or 6-membered         heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused         heterobicyclic ring system wherein each ring or ring system is         optionally substituted with 1 to 4 R⁵;     -   R¹ is K;     -   each K is independently G; C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆         alkynyl, C₃–C₆ cycloalkyl, each optionally substituted with one         or more substituents selected from the group consisting of         halogen, G, CN, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy,         C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₂–C₆         alkoxycarbonyl, C₂–C₆ alkylcarbonyl, C₃–C₆ trialkylsilyl, and a         phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each         ring optionally substituted with one to three substituents         independently selected from R⁶; hydroxy; C₁–C₄ alkoxy; C₁–C₄         alkylamino; C₂–C₈ dialkylamino; C₃–C₆ cycloalkylamino; C₂–C₆         alkoxycarbonyl and C₂–C₆ alkylcarbonyl;     -   R² is H or K; or     -   R¹ and R² are taken together to form a linking chain of 2 to 5         members including at least one carbon member, optionally         including no more than two carbon members as C(═O), and         optionally one member selected from nitrogen and oxygen,         optionally substituted with 1 to 4 substituents selected from         R³;     -   each R³ is independently C₁–C₄ alkyl, halogen, CN, NO₂ or C₁–C₂         alkoxy;     -   G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic         ring, optionally including one or two ring members selected from         the group consisting of C(═O), SO and S(O)₂ and optionally         substituted with from 1 to 4 substituents selected from R³;     -   each R⁴ is independently H, C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆         alkynyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, C₂–C₆ haloalkenyl,         C₂–C₆ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, NO₂,         hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄         alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄ haloalkylthio, C₁–C₄         haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl, C₁–C₄ alkylamino,         C₂–C₈ dialkylamino, C₃–C₆ cycloalkylamino, C₂–C₅ alkoxyalkyl,         C₁–C₄ hydroxyalkyl, C(O)R¹⁰, CO₂R¹⁰, C(O)NR¹⁰R¹¹, NR¹⁰R¹¹,         N(R¹¹)CO₂R¹⁰ or C₃–C₆ trialkylsilyl; or     -   each R⁴ is independently a phenyl, benzyl, phenoxy or a 5- or         6-membered heteroaromatic ring, each ring optionally substituted         with from one to three substituents independently selected from         R⁶;     -   each R⁵ is independently C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆         alkyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, C₂–C₆ haloalkenyl,         C₂–C₆ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, CO₂H,         CONH₂, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄         alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄         haloalkylthio, C₁–C₄ haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl         C₁–C₄ alkylamino, C₂–C₈ dialkylamino, C₃–C₆ cycloalkylamino,         C₂–C₆ alkylcarbonyl, C₂–C₆ alkoxycarbonyl, C₂–C₆         alkylaminocarbonyl, C₃–C₈ dialkylaminocarbonyl, C₃–C₆         trialkylsilyl; or     -   each R⁵ is independently a phenyl, benzyl, benzoyl, phenoxy, 5-         or 6-membered heteroaromatic ring or an aromatic 8-, 9- or         10-membered fused heterobicyclic ring system, each ring or ring         system optionally substituted with from one to three         substituents independently selected from R⁶; or     -   two R⁵ groups when attached to adjacent carbon atoms are taken         together as —OCF₂O—, —CF₂CF₂O—, or —OCF₂CF₂O—;     -   each R⁶ is independently C₁–C₄ alkyl, C₂–C₄ alkenyl, C₂–C₄         alkynyl, C₃–C₆ cycloalkyl, C₁–C₄ haloalkyl, C₂–C₄ haloalkenyl,         C₂–C₄ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, NO₂, C₁–C₄         alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl,         C₁–C₄ alkylsulfonyl, C₁–C₄ alkylamino, C₂–₈ dialkylamino, C₃–C₆         cycloalkylamino, C₄–C₈ alkyl(cycloalkyl)amino, C₂–C₄         alkylcarbonyl, C₂–C₆ alkoxycarbonyl, C₂–C₆ alkylaminocarbonyl,         C₃–C₈ dialkylaminocarbonyl or C₃–C₆ trialkylsilyl;     -   R¹⁰ is H, C₁–C₄ alkyl or C₁–C₄ haloalkyl;     -   R¹¹ is H or C₁–C₄ alkyl; and     -   n is an integer from 1 to 4.

This invention also relates to such a method wherein the invertebrate pest or its environment is contacted with a biologically effective amount of a compound of Formula I or a composition comprising a compound of Formula I and a biologically effective amount of at least one additional compound for agent for controlling invertebrate pests.

This invention also pertains to a compound of Formula Is, N-oxides or salts thereof

wherein

-   -   B is O or S;     -   J is a phenyl ring, a naphthyl ring system, a 5- or 6-membered         heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused         heterobicyclic ring system wherein each ring or ring system is         optionally substituted with 1 to 4 R⁵;     -   R² is H; G; C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl, C₃–C₆         cycloalkyl, each optionally substituted with one or more         substituents selected from the group consisting of halogen, G,         CN, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄         alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl C₂–C₆         alkoxycarbonyl, C₂–C₆ alkylcarbonyl, C₃–C₆ trialkylsilyl, and a         phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each         ring optionally substituted with one to three substituents         independently selected from R⁶; hydroxy; C₁–C₄ alkoxy; C₁–C₄         alkylamino; C₂–C₈ dialkylamino; C₃–C₆ cycloalkylamino; C₂–C₆         alkoxycarbonyl and C₂–C₆ alkylcarbonyl;     -   G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic         ring, optionally including one or two ring members selected from         the group consisting of C(═O), SO and S(O)₂ and optionally         substituted with 1 to 4 substituents selected from R³;     -   each R³ is independently C₁–C₂ alkyl, halogen, CN, NO₂ or C₁–C₂         alkoxy;     -   each R⁴ is independently H, C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆         alkyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, C₂–C₆ haloalkenyl,         C₂–C₆ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, NO₂,         hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄         alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄ haloalkylthio, C₁–C₄         haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl, C₁–C₄ alkylamino,         C₂–C₈ dialkylamino, C₃–C₆ cycloalkylamino, C₂–C₅ alkoxyalkyl,         C₁–C₄ hydroxyalkyl, C(O)R¹⁰, CO₂R¹⁰, C(O)NR¹⁰R¹¹, NR¹⁰R¹¹,         N(R¹¹)CO₂R¹⁰ or C₃–C₆ trialkylsilyl; or     -   each R⁴ is independently a phenyl, benzyl, phenoxy or a 5- or         6-membered heteroaromatic ring, each ring optionally substituted         with one to three substituents independently selected from R⁶;     -   each R⁵ is independently C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆         alkynyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, C₂–C₆ haloalkenyl,         C₂–C₆ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, CO₂H,         CONH₂, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄         alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄         haloalkylthio, C₁–C₄ haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl         C₁–C₄ alkylamino, C₂–C₈ dialkylamino, C₃–C₆ cycloalkylamino,         C₂–C₆ alkylcarbonyl, C₂–C₆ alkoxycarbonyl, C₂–C₆         alkylaminocarbonyl, C₃–C₈ dialkylaminocarbonyl or C₃–C₆         trialkylsilyl; or     -   each R⁵ is independently a phenyl, benzyl, benzoyl, phenoxy, 5-         or 6-membered heteroaromatic ring or an aromatic 8-, 9- or         10-membered fused heterobicyclic ring system, each ring         optionally substituted with from one to three substituents         independently selected from R⁶; or     -   two R⁵ groups when attached to adjacent carbon atoms are taken         together as —OCF₂O—, —CF₂CF₂O—, or —OCF₂CF₂O—;     -   each R⁶ is independently C₁–C₄ alkyl, C₂–C₄ alkenyl, C₂–C₄         alkynyl, C₃–C₆ cycloalkyl, C₁–C₄ haloalkyl, C₂–C₄ haloalkenyl,         C₂–C₄ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, NO₂, C₁–C₄         alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl,         C₁–C₄ alkylsulfonyl, C₁–C₄ alkylamino, C₂–_(C) ₈ dialkylamino,         C₃–C₆ cycloalkylamino, C₄–C₈ (alkyl)cycloalkylamino, C₂–C₄         alkylcarbonyl, C₂–C₆ alkoxycarbonyl, C₂–C₆ alkylaminocarbonyl,         C₃–C₈ dialkylaminocarbonyl or C₃–C₆ trialkylsilyl;     -   R¹⁰ is H, C₁–C₄ alkyl or C₁–C₄ haloalkyl;     -   R¹¹ is H or C₁–C₄ alkyl; and     -   n is an integer from 1 to 4.

This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. This invention also pertains to such compositions optionally further comprising an effective amount of at least one additional biologically active compound or agent.

DETAILS OF TH INVENTION

In the above recitations, the term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl” includes straight-chain or branched alkenes such as 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynes such as 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. “Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers. “Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH₃OCH₂, CH₃OCH₂CH₂, CH₃CH₂OCH₂, CH₃CH₂CH₂CH₂OCH₂ and CH₃CH₂OCH₂CH₂. “Alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio, butylthio, pentylthio and hexylthio isomers. “Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. “Trialkylsilyl” includes (CH₃)₃Si, (CH₃CH₂)₃Si and [(CH₃)₃C](CH₃)₂Si. “(Alkyl)cycloalkylamino” means a cycloalkylamino group where the hydrogen atom is replaced by an alkyl radical; examples include groups such as (methyl)cyclopropylamino, (ethyl)cyclobutylamino, (iso-propyl)cyclopentylamino and (methyl)cyclohexylamino. As indicated in the Summary of the Invention, the cycloalkyl in cycloalkylamino and (alkyl)cycloalkylamino is C₃–C₆ cycloalkyl, while the alkyl in (alkyl)cycloalkylamino is C₁–C₄ alkyl.

The term “aromatic” indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and in which (4n+2) π electrons, when n is 0 or a positive integer, are associated with the ring to comply with Hückel's rule. The term “aromatic ring system” denotes fully unsaturated carbocycles and heterocycles in which at least one ring of a polycyclic ring system is aromatic. Aromatic carbocyclic ring or fused carbobicyclic ring systems includes fully aromatic carbocycles and carbocycles in which at least one ring of a polycyclic ring system is aromatic (e.g. phenyl and naphthyl). The term “nonaromatic carbocyclic ring” denotes fully saturated carbocycles as well as partially or fully unsaturated carbocycles where the Hückel rule is not satisfied by the ring. The term “hetero” in connection with rings or ring systems refers to a ring or ring system in which at least one ring atom is not carbon and which can contain 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur, provided that each ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs. The terms “heteroaromatic ring or ring system” and “aromatic fused heterobicyclic ring system” includes fully aromatic heterocycles and heterocycles in which at least one ring of a polycyclic ring system is aromatic (where aromatic indicates that the Hückel rule is satisfied). The term “nonaromatic heterocyclic ring or ring system” denotes fully saturated heterocycles as well as partially or fully unsaturated heterocycles where the Hückel rule is not satisfied by any of the rings in the ring system. The heterocyclic ring or ring system can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

The term “halogen”, either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” include F₃C, ClCH₂, CF₃CH₂ and CF₃CCl₂. The terms “haloalkenyl”, “haloalkynyl”, “haloalkoxy”, and the like, are defined analogously to the term “haloalkyl”. Examples of “haloalkenyl” include (Cl)₂C═CHCH₂ and CF₃CH₂CH═CHCH₂. Examples of “haloalkynyl” include HC≡CCHCl, CF₃C≡C, CCl₃C≡C and FCH₂C≡CCH₂. Examples of “haloalkoxy” include CF₃O, CCl₃CH₂O, HCF₂CH₂CH₂O and CF₃CH₂O.

Examples of “alkylcarbonyl” include C(O)CH₃, C(O)CH₂CH₂CH₃ and C(O)CH(CH₃)₂. Examples of “alkoxycarbonyl” include CH₃OC(═O), CH₃CH₂OC(═O), CH₃CH₂CH₂OC(═O), (CH₃)₂CHOC(═O) and the different butoxy- or pentoxycarbonyl isomers. Examples of “alkylaminocarbonyl” include CH₃NHC(═O), CH₃CH₂NHC(═O), CH₃CH₂CH₂NHC(═O), (CH₃)₂CHNHC(═O) and the different butylamino- or pentylaminocarbonyl isomers. Examples of “dialkylaminocarbonyl” include (CH₃)₂NC(═O), (CH₃CH₂)₂NC(═O), CH₃CH₂(CH₃)NC(═O), CH₃CH₂CH₂(CH₃)NC(═O), and (CH₃)₂CHN(CH₃)C(═O).

The total number of carbon atoms in a substituent group is indicated by the “C_(i)–C_(j)” prefix where i and j are numbers from 1 to 8. For example, C₁–C₄ alkylsulfonyl designates methylsulfonyl through butylsulfonyl; C₂ alkoxyalkyl designates CH₃OCH₂; C₃ alkoxyalkyl designates, for example, CH₃CH(OCH₃), CH₃OCH₂CH₂ or CH₃CH₂OCH₂; and C₄ alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH₃CH₂CH₂OCH₂ and CH₃CH₂OCH₂CH₂. In the above recitations, when a compound of Formula I comprises a heterocyclic ring, all substituents are attached to this ring through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. Further, when the subscript indicates a range, e.g. (R)_(i-j), then the number of substituents may be selected from the integers between i and j inclusive.

The term “optionally substituted” indicates that a moiety may be substituted or unsubstituted. The term “optionally substituted with from one to three substituents” and the like indicates that the moiety may be unsubstituted or from one to three of the available positions on the moiety may be substituted. When a moiety contains a substituent which can be hydrogen, for example R⁴, then, when this substituent is taken as hydrogen, it is recognized that this is equivalent to said moiety being unsubstituted.

Compounds of Formula I can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. Of note are geometric isomers in which R² of the imino moiety may be syn or anti relative to B, or a mixture of syn and anti geometric isomers. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. Accordingly, the compounds of Formula I may be present as a mixture of stereoisomers, individual stereoisomers, or as an optically active form. Some compounds of Formula I can exist as one or more tautomers, and all tautomeric forms of such compounds are part of the present invention. Accordingly, the compounds of the invention may be present as a mixture of tautomers or the individual tautomers.

The present invention comprises compounds selected from Formula I, N-oxides and salts thereof. One skilled in the art will appreciate that not all nitrogen containing heterocycles can form N-oxides since the nitrogen requires an available lone pair of electrons for oxidation to the oxide; one skilled in the art will recognize those nitrogen containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethydioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748–750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, Vol. 3, pp 18–19, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, Vol. 43, pp 139–151, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, Vol. 9, pp 285–291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, Vol. 22, pp 390–392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

The salts of the compounds of the invention include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. The salts of the compounds of the invention also include those formed with organic bases (e.g., pyridine, ammonia, or triethylamine) or inorganic bases (e.g., hydrides, hydroxides, or carbonates of sodium, potassium, lithium, calcium, magnesium or barium) when the compound contains an acidic moiety such as a carboxylic acid or phenol.

As noted above, J is a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R⁵. The term “optionally substituted” in connection with these J groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. An example of phenyl optionally substituted with 1 to 4 R⁵ is the ring illustrated as U-1 in Exhibit 1, wherein R^(v) is R⁵ and r is an integer from 0 to 4. An example of a naphthyl group optionally substituted with 1 to 4 R⁵ is illustrated as U-85 in Exhibit 1, wherein R^(v) is R⁵ and r is an integer from 0 to 4. Examples of 5- or 6-membered heteroaromatic rings optionally substituted with 1 to 4 R⁵ include the rings U-2 through U-53 illustrated in Exhibit 1 wherein R^(v) is R⁵ and r is an integer from 0 to 4. Note that J-1 through J-5 below also denote 5- or 6-membered heteroaromatic rings. Note that U-2 through U-20 are examples of J-1, U-21 through U-35 and U-40 are examples of J-2, U-36 through U-39 are examples of J-3, U-41 through U-48 are examples of J-4 and U-49 through U-53 are examples of J-5. Examples of aromatic 8-, 9- or 10-membered fused heterobicyclic ring systems optionally substituted with 1 to 4 R⁵ include U-54 through U-84 illustrated in Exhibit 1 wherein R^(v) is R⁵ and r is an integer from 0 to 4.

The nitrogen atoms that require substitution to fill their valence are substituted with H or R^(v). Note that some U groups can only be substituted with less than 4 R^(v) groups (e.g. U-14, U-15, U-18 through U-21 and U-32 through U-34 can only be substituted with one R^(v)). Note that when the attachment point between (R^(v))_(r) and the U group is illustrated as floating, (R^(v))_(r) can be attached to any available carbon atom of the U group. Note that when the attachment point on the U group is illustrated as floating, the U group can be attached to the remainder of Formula I through any available carbon of the U group by replacement of a hydrogen atom.

Exhibit 1

As noted above G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring, optionally including one or two ring members selected from the group consisting of C(═O), SO and S(O)₂ and optionally substituted with 1 to 4 substituents selected from R³. Examples of such G groups include those illustrated as G-1 through G-41 in Exhibit 2 wherein m is an integer from 0 to 4. The term “optionally substituted” in connection with these G groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. Note that when the attachment point on these G groups is illustrated as floating, the G group can be attached to the remainder of Formula I through any available carbon or nitrogen of the G group by replacement of a hydrogen atom. The optional substituents can be attached to any available carbon or nitrogen by replacing a hydrogen atom. Note that when G comprises a ring selected from G-24 through G-29 and G-32 through G-35, A is selected from O, S or NR³. Note that when G is G-3, G-5, G-7, G-9, G-16 through G-18, G-23, and G-24 through G-29, and G-32 through G-35 (when A is NR³), the nitrogen atoms that require substitution to fill their valence are substituted with H or R³.

Exhibit 2

As noted above, certain R¹ and R² groups can be optionally substituted with one or more substituents. The term “optionally substituted” in connection with these groups refers to R¹ and/or R² groups that are unsubstituted or have at least one non-hydrogen substituent. Examples of optionally substituted R¹ and/or R² groups are those that are optionally substituted by replacement of a hydrogen on a carbon atom of the R¹ and/or R² group with one or more (up to the total number of hydrogens available for replacement in any specific R¹ and/or R² group) substituents independently selected from the substituents listed in the Summary of the Invention above. Although these substituents are listed, it is noted that they do not need to be present since they are optional substituents. Of note are R¹ and/or R² groups that are unsubstituted. Of note are R¹ and/or R² groups substituted with one to five substituents. Also of note are R¹ and/or R² groups substituted with one substituent.

As noted above, each R¹ and R² can be independently (among others) C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl or C₃–C₆ cycloalkyl, each optionally substituted with one or more substituents selected from (among others) a phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R⁶. The term “optionally substituted” in connection with these groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. Examples of such substituents include the rings illustrated as U-1 through U-53 and U-88 illustrated in Exhibit 1, except that such rings are optionally substituted with 1 to 3 substituents independently selected from R⁶ rather than (R^(v))_(r). Note that R⁶ substituents do not need to be present since they are optional substituents.

As noted above, each R⁴ is independently (among others) a phenyl, benzyl, phenoxy or a 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R⁶. The term “optionally substituted” in connection with these R⁴ groups refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. Examples of such R⁴ groups include the rings illustrated as U-1 through U-53, U-86 and U-88 illustrated in Exhibit 1, except that such rings are optionally substituted with 1 to 3 substituents independently selected from R⁶ rather than (R^(v))_(r). Note that R⁶ substituents do not need to be present since they are optional substituents.

As noted above, each R⁵ is independently (among others) a phenyl, benzyl, benzoyl, phenoxy, 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, each ring or ring system optionally substituted with one to three substituents independently selected from R⁶. Examples of such R⁵ groups include the rings and ring systems illustrated as U-1 through U-88 illustrated in Exhibit 1, except that such rings and ring systems are optionally substituted with 1 to 3 substituents independently selected from R⁶ rather than (R^(v))_(r). Note that R⁶ substituents do not need to be present since they are optional substituents.

Preferred for reasons of cost, ease of synthesis or application, and/or biological efficacy are:

-   -   Preferred 1. Methods comprising compounds of Formula I wherein         -   R² is H; or C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl or             C₃–C₆ cycloalkyl, each optionally substituted with one or             more substituents selected from the group consisting of             halogen, CN, C₁–C₂ alkoxy, C₁–C₂ alkylthio, C₁–C₂             alkylsulfinyl and C₁–C₂ alkylsulfonyl;         -   one R⁴ group is attached to the phenyl ring at the             2-position or 5-position, and said R⁴ is C₁–C₄ alkyl, C₁–C₄             haloalkyl, halogen, CN, NO₂, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy,             C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl,             C₁–C₄ haloalkylthio, C₁–C₄ haloalkylsulfinyl or C₁–C₄             haloalkylsulfonyl; and         -   n is 1 or 2.     -   Preferred 2. Methods of Preferred 1 wherein J is a phenyl group         optionally substituted with 1 to 4 R⁵.     -   Preferred 3. Methods of Preferred 2 wherein         -   B is O; and         -   each R⁵ is independently halogen, C₁–C₄ alkyl, C₁–C₂ alkoxy,             C₁–C₄ haloalkyl, CN, NO₂, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio,             C₁–C₄ alkylsulfinyl C₁–C₄ alkylsulfonyl, C₁–C₄             haloalkylthio, C₁–C₄ haloalkylsulfinyl C₁–C₄             haloalkylsulfonyl or C₂–C₄ alkoxycarbonyl; or         -   each R⁵ is independently a phenyl or a 5- or 6-membered             heteroaromatic ring, each ring optionally substituted with             one to three substituents independently selected from R⁶; or         -   two R⁵ groups when attached to adjacent carbon atoms are             taken together as —OCF₂O—, —CF₂CF₂O—, or —OCF₂CF₂O—.     -   Preferred 4. Methods of Preferred 3 wherein         -   R² is C₁–C₄ alkyl optionally substituted with halogen, CN,             OCH₃ or S(O)_(p)CH₃;         -   one R⁴ group is attached to the phenyl ring at the             2-position and said R⁴ is CH₃, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, CN or halogen;         -   a second R⁴ is H, F, Cl, Br, I. CN or CF₃;         -   each R⁵ is independently halogen, methyl, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, OCH₂CF₃, OCF₂CHF₂, S(O)_(p)CH₂CF₃             or S(O)_(p)CF₂CHF₂; or a phenyl, pyrazole, imidazole,             triazole, pyridine or pyrimidine ring, each ring optionally             substituted with one to three substituents independently             selected from C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen and CN;             and         -   p is 0, 1 or 2.     -   Preferred 5. Methods of Preferred 4 wherein R² is H, Me, Et,         i-propyl or t-butyl.     -   Preferred 6. Methods of Preferred 1 wherein         -   J is a 5- or 6-membered heteroaromatic ring selected from             the group consisting of J-1, J-2, J-3, J-4 and J-5, each J             optionally substituted with 1 to 3 R⁵

-   -   -   Q is O, S, NH or NR⁵; and         -   W, X, Y and Z are independently N, CH or CR⁵, provided that             in J-4 and J-5 at least one of W, X, Y or Z is N.

    -   Preferred 7. Methods of Preferred 6 wherein         -   B is O; and         -   each R⁵ is independently C₁–C₄ alkyl, C₁–C₄ haloalkyl,             halogen, CN, NO₂, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄             alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄ haloalkylthio,             C₁–C₄ haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl or C₂–C₄             alkoxycarbonyl; or a phenyl or a 5- or 6-membered             heteroaromatic ring, each ring optionally substituted with             one to three substituents independently selected from R⁶.

    -   Preferred 8. Methods of Preferred 7 wherein         -   J substituted with 1 to 3 R⁵ is selected from the group             consisting of J-6, J-7, J-8, J-9, J-10, J-11, J-12 and J-13

-   -   -   V is N, CH, CF, CCl, CBr or CI;         -   each R^(6a) is independently H or R⁶;         -   R⁶ is C₁–C₆ alkyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl,             halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄             haloalkylthio;         -   each R⁷ is independently C₁–C₆ alkyl, C₁–C₆ haloalkyl,             halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄             haloalkylthio;         -   R⁹ is C₂–C₆ alkyl, C₁–C₆ haloalkyl, C₃–C₆ alkenyl, C₃–C₆             haloalkenyl, C₃–C₆ alkynyl or C₃–C₆ haloalkynyl;         -   R¹⁰ is C₁–C₄ alkyl or C₁–C₄ haloalkyl;         -   R¹¹ is C₁–C₄ alkyl; and         -   n is 1 or 2.

Note that R⁷ and R⁹ are subsets of R⁵. Note that the F, Cl, Br or I atoms encompassed within V are a subset of R⁶. Of note are methods of Preferred 8 wherein V is N. Also of note are methods of Preferred 8 wherein V is CH, CF, CCl or CBr. Of particular note are methods of Preferred 8 wherein V is N or CH.

-   -   Preferred 9. Methods of Preferred 8 wherein         -   R² is C₁–C₄ alkyl optionally substituted with halogen, CN,             OCH₃ or S(O)_(p)CH₃; or CH₂C≡CH;         -   one R⁴ group is attached to the phenyl ring at the             2-position and said R⁴ is CH₃, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, CN or halogen;         -   a second R⁴ is H, F, Cl, Br, I, CN or CF₃;         -   R^(6a) is H, C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen or CN;         -   R⁷ is CH₃, CF₃, OCH₂CF₃, OCHF₂ or halogen;         -   R⁹ is CH₂CF₃, CHF₂ or CF₃; and         -   p is 0, 1 or 2.

Of note are methods of Preferred 9 wherein one R⁴ group is attached to the phenyl ring at the 2-position and said R⁴ is CH₃, Cl or Br; and a second R⁴ is H, F, Cl, Br, I, CN or CF₃.

-   -   Preferred 10. Methods of Preferred 9 wherein J substituted with         1 to 3 R⁵ is J-6; V is N or CH; and R⁷ is CH₃, CF₃, OCH₂CF₃,         OCHF₂ or halogen.     -   Preferred 11. Methods of Preferred 10 wherein R^(6a) is F, Cl or         Br; and R⁷ is halogen or CF₃.     -   Preferred 12. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-7; and R⁹ is C₂–C₆ alkyl or C₁–C₆ haloalkyl.

Of note are methods of Preferred 12 wherein V is N or CH; R^(6a) is Cl or Br; and R⁹ is CF₃, CHF₂, CH₂CF₃, CF₂CHF₂.

-   -   Preferred 13. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-8; V is N; R^(6a) is Cl or Br; and R⁷ is         halogen or CF₃.     -   Preferred 14. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-9; R^(6a) is Cl or Br; and R⁷ is CF₃.     -   Preferred 15. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-10; R^(6a) is Cl or Br; and R⁹ is CH₂CF₃,         CHF₂ or CF₃.     -   Preferred 16. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-11; R^(6a) is Cl or Br; and R⁷ is halogen,         OCH₂CF₃, OCHF₂ or CF₃.     -   Preferred 17. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-12; R^(6a) is Cl or Br; R⁷ is halogen,         OCH₂CF₃, OCHF₂ or CF₃; and R⁹ is CH₂CF₃, CHF₂ or CF₃.     -   Preferred 18. Methods of Preferred 9 wherein J substituted with         from 1 to 3 R⁵ is J-13; R^(6a) is Cl or Br; and R⁹ is CH₂CF₃,         CHF₂ or CF₃.

Specifically preferred methods are those comprising compounds selected from the group consisting of:

-   -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine,     -   N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine         and     -   N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine.

Also preferred are:

-   -   Preferred 19. Methods of Preferred 1 wherein         -   B is NR¹;         -   J substituted with from 1 to 3 R⁵ is J-6 (as defined above             in Preferred 8);         -   each R¹ is independently C₁–C₆ alkyl;         -   R² is H or C₁–C₆ alkyl; or         -   R¹ and R² are taken together to form a linking chain of 2 to             5 members including at least one carbon member, optionally             including no more than two carbon members as C(═O), and             optionally one member selected from nitrogen and oxygen,             optionally substituted with 1 to 4 substituents selected             from R³;         -   each R³ is independently C₁–C₂ alkyl, halogen, CN, NO₂ or             C₁–C₂ alkoxy; and         -   one R⁴ group is attached to the phenyl ring at the             2-position and said R⁴ is CH₃, Cl or Br; and a second R⁴ is             H, F, Cl, Br, I or CF₃.

Of further note are methods comprising compounds of Preferred 19, R¹ and R² can be taken together to form a linking chain selected from the group consisting of —CH₂CH₂—, —CH₂CH₂CH₂—, —CH₂CH₂C(═O)—, —CH═C(CH₃)—, —C(CH₃)═CH—, and —CH═N—; such that the left end of the moiety is attached at the R¹ location and the right end of the moiety is attached at the R² location.

Specifically preferred is the method of Preferred 19 comprising the compound:

-   -   7,9-Dichloro-5-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2,3-dihydroimidazo[1,2-c]quinazoline.

This invention also pertains to compositions for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I. Preferred compositions are those comprising the compounds described in Preferred 1 through Preferred 19 and those listed in the specifically preferred methods above.

-   -   Preferred compounds for ease of synthesis and/or biological         efficacy are:     -   Preferred A. Compounds of Formula I wherein         -   B is O;         -   R² is H or C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl or             C₃–C₆ cycloalkyl each optionally substituted with one or             more substituents selected from the group consisting of             halogen, CN, C₁–C₂ alkoxy, C₁–C₂ alkylthio, C₁–C₂             alkylsulfinyl and C₁–C₂ alkylsulfonyl;         -   one R⁴ group is attached to the phenyl ring at the             2-position or 5-position, and said R⁴ is C₁–C₄ alkyl, C₁–C₄             haloalkyl halogen, CN, NO₂, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy,             C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl,             C₁–C₄ haloalkylthio, C₁–C₄ haloalkylsulfinyl or C₁–C₄             haloalkylsulfonyl;         -   each R⁵ is independently halogen, C₁–C₄ alkyl, C₁–C₂ alkoxy,             C₁–C₄ haloalkyl, CN, NO₂, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio,             C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl C₁–C₄             haloalkylthio, C₁–C₄ haloalkylsulfinyl, C₁–C₄             haloalkylsulfonyl or C₂–C₄ alkoxycarbonyl; or         -   each R⁵ is independently a phenyl or a 5- or 6-membered             heteroaromatic ring, each ring optionally substituted with             one to three substituents independently selected from R⁶; or         -   two R⁵ groups when attached to adjacent carbon atoms are             taken together as —OCF₂O—, —CF₂CF₂O—, or —OCF₂CF₂O—; and         -   n is 1 or 2.     -   Preferred B. Compounds of Preferred A wherein         -   J is a phenyl group optionally substituted with from 1 to 4             R⁵;         -   R² is C₁–C₄ alkyl optionally substituted with halogen, CN,             OCH₃ or S(O)_(p)CH₃;         -   one R⁴ group is attached to the phenyl ring at the             2-position and said R⁴ is CH₃, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, CN or halogen;         -   a second R⁴ is H, F, Cl, Br, I or CF₃;         -   each R⁵ is independently halogen, methyl, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, OCH₂CF₃, OCF₂CHF₂, S(O)_(p)CH₂CF₃             or S(O)_(p)CF₂CHF₂; or a phenyl, pyrazole, imidazole,             triazole, pyridine or pyrimidine ring, each ring optionally             substituted with one to three substituents independently             selected from C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen and CN;             and         -   p is 0, 1 or 2.     -   Preferred C. Compounds of Preferred B wherein R² is H, Me, Et,         i-propyl or t-butyl.     -   Preferred D. Compounds of Preferred A wherein         -   J is a 5- or 6-membered heteroaromatic ring selected from             the group consisting of J-1, J-2, J-3, J-4 and J-5, each J             optionally substituted with 1 to 3 R⁵

-   -   -   Q is O, S, NH or NR⁵; and         -   W, X, Y and Z are independently N, CH or CR⁵, provided that             in J-4 and J-5 at least one of W, X, Y or Z is N; and         -   each R⁵ is independently C₁–C₄ alkyl, C₁–C₄ haloalkyl,             halogen, CN, NO₂, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄             alkylsulfinyl C₁–C₄ alkylsulfonyl C₁–C₄ haloalkylthio, C₁–C₄             haloalkylsulfinyl C₁–C₄ haloalkylsulfonyl or C₂–C₄             alkoxycarbonyl; or a phenyl or a 5- or 6-membered             heteroaromatic ring, each ring optionally substituted with             one to three substituents independently selected from R⁶.

    -   Preferred E. Compounds of Preferred D wherein         -   J substituted with 1 to 3 R⁵ is selected from the group             consisting of J-6, J-7, J-8, J-9, J-10, J-11, J-12 and J-13

-   -   -   V is N, CH, CF, CCl, CBr or CI;         -   each R^(6a) is independently H or R⁶;         -   R⁶ is C₁–C₆ alkyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl,             halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄             haloalkylthio;         -   each R⁷ is independently C₁–C₆ alkyl, C₁–C₆ haloalkyl,             halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄             haloalkylthio;         -   R⁹ is C₂–C₆ alkyl, C₁–C₆ haloalkyl, C₃–C₆ alkenyl, C₃–C₆             haloalkenyl, C₃–C₆ alkynyl or C₃–C₆ haloalkynyl;         -   R¹⁰ is C₁–C₄ alkyl or C₁–C₄ haloalkyl;         -   R¹¹ is C₁–C₄ alkyl; and         -   n is 1 or 2.

Note that R⁷ and R⁹ are subsets of R⁵. Note that the F, Cl, Br or I atoms encompassed within V are a subset of R⁶. Of note are compounds of Preferred E wherein V is N. Also of note are compounds of Preferred E wherein V is CH, CF, CCl or CBr. Of particular note are compounds of Preferred E wherein V is N or CH.

-   -   Preferred F. Compounds of Preferred E wherein         -   R² is C₁–C₄ alkyl optionally substituted with halogen, CN,             OCH₃ or S(O)_(p)CH₃; or CH₂C≡CH;         -   one R⁴ group is attached to the phenyl ring at the             2-position and said R⁴ is CH₃, CF₃, OCF₃, OCHF₂,             S(O)_(p)CF₃, S(O)_(p)CHF₂, CN or halogen;         -   a second R⁴ is H, F, Cl, Br, I or CF₃;         -   R^(6a) is H, C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen or CN;         -   R⁷ is CH₃, CF₃, OCH₂CF₃, OCHF₂ or halogen;         -   R⁹ is CH₂CF₃, CHF₂ or CF₃; and         -   p is 0, 1 or 2.

Of note are compounds of Preferred F wherein one R⁴ group is attached to the phenyl ring at the 2-position and said R⁴ is CH₃, Cl or Br; and a second R⁴ is H, F, Cl, Br, I or CF₃.

-   -   Preferred G. Compounds of Preferred F wherein J substituted with         from 1 to 3 R⁵ is J-6;         -   V is N or CH; and R⁷ is CH₃, CF₃, OCH₂CF₃, OCHF₂ or halogen.     -   Preferred H. Compounds of Preferred G wherein R^(6a) is F, Cl or         Br; and R⁷ is halogen or CF₃.     -   Preferred I. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-7; and R⁹ is C₂–C₆ alkyl or C₁–C₆ haloalkyl.

Of note are compounds of Preferred I wherein V is N or CH; R^(6a) is Cl or Br; and R⁹ is CF₃, CHF₂, CH₂CF₃, CF₂CHF₂.

-   -   Preferred J. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-8; V is N; R^(6a) is Cl or Br; and R⁷ is halogen         or CF₃.     -   Preferred K. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-9; R^(6a) is Cl or Br; and R⁷ is CF₃.     -   Preferred L. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-10; R^(6a) is Cl or Br; and R⁹ is CHF₂CF₃, CHF₂         or CF₃.     -   Preferred M. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-11; R^(6a) is Cl or Br; and R⁷ is halogen,         OCH₂CF₃, OCHF₂ or CF₃.     -   Preferred N. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-12; R^(6a) is Cl or Br; R⁷ is halogen, OCH₂CF₃,         OCHF₂ or CF₃; and R⁹ is CH₂CF₃, CHF₂ or CF₃.     -   Preferred O. Compounds of Preferred F wherein J substituted with         1 to 3 R⁵ is J-13; R^(6a) is Cl or Br; and R⁹ is CH₂CF₃, CHF₂ or         CF₃.

Specifically preferred are compounds selected from the group consisting of:

-   -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine,     -   N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine,     -   N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine,     -   N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine         and     -   N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine.

Of note are compounds of Formula I wherein

-   -   B is NR¹;     -   J substituted with 1 to 3 R⁵ is J-6 (as defined above in         Preferred 8);     -   each R¹ is independently C₁–C₆ alkyl;     -   R² is H or C₁–C₆ alkyl; or     -   R¹ and R² are taken together to form a linking chain of 2 to 5         members including at least one carbon member, optionally         including no more than two carbon members as C(═O), and         optionally one additional member selected from nitrogen and         oxygen, optionally substituted with from 1 to 4 substituents         selected from R³;     -   each R³ is independently C₁–C₂ alkyl, halogen, CN, NO₂ or C₁–C₂         alkoxy; and     -   one R⁴ group is attached to the phenyl ring at the 2-position         and said R⁴ is CH₃, Cl or Br; and a second R⁴ is H, F, Cl, Br, I         or CF₃.

Of further note are compounds wherein in Formula I, R¹ and R² can be taken together to form a linking chain selected from the group consisting of —CH₂CH₂—, —CH₂CH₂CH₂—, —CH₂CH₂C(═O)—, —CH═C(CH₃)—, —C(CH₃)═CH—, and —CH═N—; such that the left end of the moiety is attached at the R¹ location and the right end of the moiety is attached at the R² location.

Specifically preferred is the compound:

-   -   7,9-Dichloro-5-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2,3-dihydroimidazo[1,2-c]quinazoline.

One or more of the following methods and variations as described in Schemes 1–35 can be used to prepare the compounds of Formula I. The definitions of B, J, V, R¹ through R⁶ and n in the compounds of Formulae I, II and 2–96 below are as defined above in the Summary of the Invention. Compounds of Formulae Ia–f, IIa–c, 3a, 4a–t, 10a, 18a, 19a–c and 20a are various subsets of the compounds of Formula I, II, 3, 4, 10, 18, 19 and 20, respectively.

Compounds of Formula Ia or Ib (compounds of Formula I wherein B is O or S respectively) can be prepared from compounds of Formula IIa or Formula IIb respectively by cyclization in the presence of dehydration agents such as POCl₃, POCl₃/PCl₅, SOCl₂ or oxalyl chloride. This cyclization is typically conducted in solvents such as dichloroethane, dichloromethane, chloroform, benzene, toluene, xylenes, hexanes, cyclohexane, 1,4-dioxane, tetrahydrofuran and chlorobenzene in the temperature range from 0° C. to the reflux temperature of the mixture. Alternatively, the dehydrative cyclization can be effected by treatment of Formula IIa or Formula IIb with triphenyl phosphine and either bromine or iodine, optionally in the presence of tertiary amine bases such as triethylamine or diisopropylethylamine. See Monatsh. Chem. 1989, 120, 973–980 and J. Org. Chem. 2000, 65, 1022–1030 for representative procedures.

Coupling of an amine of Formula 2 with an acid chloride of Formula 3 in the presence of an acid scavenger can provide the compound of Formula IIa (Scheme 2).

Typical acid scavengers include amine bases such as triethylamine, diisopropylethylamine and pyridine; other scavengers include hydroxides such as sodium and potassium hydroxide and carbonates such as sodium carbonate and potassium carbonate. In certain instances it is useful to use polymer-supported acid scavengers such as polymer-bound diisopropylethylamine and polymer-bound dimethylaminopyridine. The coupling can be run in a suitable inert solvent such as tetrahydrofuran, dioxane, diethylether or dichloromethane to afford the anilide of Formula IIa

In a subsequent step, amides of Formula IIa can be converted to thioamides of Formula IIb using a variety of standard thio transfer reagents including phosphorus pentasulfide and Lawesson's reagent.

An alternate procedure for the preparation of compounds of Formula IIa involves coupling of an amine of Formula 2 with an acid of Formula 4 in the presence of a dehydrating agent such as dicyclohexylcarbodimide (DCC), 1,1′-carbonyldiimidazole, bis(2-oxo-3-oxazolidinyl)phosphinic chloride or benzotriazol-1-yloxy-tris-(dimethylamino)-phosphonium hexafluorophosphate (Scheme 3). Polymer supported reagents are again useful here, such as polymer-bound cyclohexylcarbodiimide. The coupling can be run in a suitable inert solvent such as dichloromethane or N,N-dimethylformamide. Synthetic procedures of Schemes 2 and 3 are only representative examples of useful methods for the preparation of Formula II compounds as the synthetic literature is extensive for this type of reaction.

One skilled in the art will also realize that acid chlorides of Formula 3 may be prepared from acids of Formula 4 by numerous well-known methods. For example, acid chlorides of Formula 3 are readily made from carboxylic acids of Formula 4 by reacting the carboxylic acid 4 with thionyl chloride or oxalyl chloride in an inert solvent such as toluene or dichloromethane in the presence of a catalytic amount of N,N-dimethylformamide.

Amines of Formula 2 are typically available from the corresponding 2-nitrobenzamides of Formula 5 via catalytic hydrogenation of the nitro group (Scheme 4). Typical procedures involve reduction with hydrogen in the presence of a metal catalyst such as palladium on carbon or platinum oxide and in hydroxylic solvents such as ethanol and isopropanol. They can also be prepared by reduction with zinc in acetic acid. These procedures are well documented in the chemical literature.

The intermediate 2-nitrobenzamides of Formula 5 are readily prepared from commercially available 2-nitrobenzoic acids (Scheme 5). Typical methods for amide formation can be applied here. These include direct dehydrative coupling of acids of Formula 6 with amines of Formula 7 using for example DCC, and conversion of the acids to activated forms such as the acid chlorides or anhydrides and subsequent coupling with amines to form amides of Formula 5. Alkyl chloroformates, such as ethyl chloroformate or isopropyl chloroformate, are especially useful reagents for this type of reaction involving activation of the acid. The chemical literature is extensive on methods for amide formation.

Intermediate anthranilic amides of Formula 2 may also be prepared from isatoic anhydrides of Formula 8 as shown in Scheme 6. Typical procedures involve combination of equimolar amounts of the amine 7 with the isatoic anhydride in polar aprotic solvents such as pyridine and N,N-dimethylformamide at temperatures ranging from room temperature to 100° C. Isatoic anhydrides of Formula 8 may be made by methods described in Coppola, Synthesis 1980, 505–36.

As shown in Scheme 7, an alternate procedure for the preparation of compounds of Formula IIa involves reaction of an amine of Formula 7 with a benzoxazinone of Formula 10. The reaction of Scheme 7 can be run neat or in a variety of suitable solvents including tetahydrofuran, diethyl ether, pyridine, dichloromethane or chloroform with optimum temperatures ranging from room temperature to the reflux temperature of the solvent. The general reaction of benzoxazinones with amines to produce anthranilamides is well documented in the chemical literature. For a review of benzoxazinone chemistry see Jakobsen et al., Biorganic and Medicinal Chemistry 2000, 8, 2095–2103 and references cited therein. See also Coppola, J. Heterocyclic Chemistry 1999, 36, 563–588.

Benzoxazinones of Formula 10 can be prepared by a variety of procedures. Two procedures that are especially useful are detailed in Schemes 8 and 9. In Scheme 8, a benzoxazinone of Formula 10 is prepared directly via coupling of a carboxylic acid of Formula 4 with an anthranilic acid of Formula 11. This involves sequential addition of methanesulfonyl chloride to a carboxylic acid of Formula 4 in the presence of an amine base such as triethylamine or pyridine, followed by the addition of an anthranilic acid of Formula 11, followed by a second addition of triethylamine and methanesulfonyl chloride. This procedure generally affords good yields of the benzoxazinone and is especially useful for preparing compounds of Formula 10a from pyrazolecarboxylic acids of Formula 4a

Scheme 9 depicts an alternate preparation for benzoxazinones of Formulae 10 and 10a involving coupling of an acid chloride of Formula 3 with an isatoic anhydride of Formula 8 to provide the Formula 10 benzoxazinone directly. Compounds of Formula 10a can be prepared from the pyrazole acid chloride of Formula 3a by a similar procedure. Solvents such as pyridine or pyridine/acetonitrile are suitable for this reaction. The acid chlorides of Formula 3a are available from the corresponding acids of Formula 4a by known procedures such as chlorination with thionyl chloride or oxalyl chloride.

Preparation of the isatoic anhydrides of Formula 8 can be achieved from isatins of Formula 13 as outlined in Scheme 10. Isatins of Formula 13 are available from aniline derivatives of Formula 12 following literature procedures. Oxidation of isatin 13 with hydrogen peroxide generally affords good yields of the corresponding isatoic anhydride 8 (Angew. Chem. Int. Ed. Engl. 1980, 19, 222–223). Isatoic anhydrides are also available from the anthranilic acids 11 via many known procedures involving reaction of 11 with phosgene or a phosgene equivalent.

Compounds of Formula Ic or Id (compounds of Formula I wherein B is NR¹) can be prepared from anthranilonitriles of Formula 14 by cyclization with an amide of Formula 15 in the presence of dehydration agents such as POCl₃, POCl₃/PCl₅ or SOCl₂ (Scheme 11). This cyclization is typically conducted in solvents such as dichloroethane, dichloromethane, chloroform, benzene, toluene, xylenes, hexanes, cyclohexane, 1,4-dioxane, tetrahydrofuran and chlorobenzene in the temperature range from 0° C. to the reflux temperature of the mixture. The resultant compounds of Formula Ic (wherein R² is H) can be treated with electrophiles of Formula 16 (wherein Lg is a leaving group such as halogen and alkyl or aryl suphonates), optionally in the presence of an acid scavenger, to provide compounds of Formula Id (wherein R² is other than H). Typical acid scavengers include amine bases such as triethylamine, diisopropylethylamine and pyridine; other scavengers include hydroxides such as sodium and potassium hydroxide and carbonates such as sodium carbonate and potassium carbonate. In certain instances it is useful to use polymer-supported acid scavengers such as polymer-bound diisopropylethylamine and polymer-bound dimethylaminopyridine. These reactions are typically conducted in solvents such as dichloroethane, dichloromethane, chloroform, benzene, toluene, xylenes, hexanes, cyclohexane, 1,4-dioxane, tetrahydrofuran dimethylsufoxide N,N-dimethylformamide, N,N-dimethylacetamide and chlorobenzene in the temperature range from 0° C. to the reflux temperature of the mixture. Compounds of Formula Id may be prepared from compounds of Formulae 14 and 15 (wherein R¹ is H) by similar procedures. Alkylation of Formula Id with an alkylating agent with two leaving groups (e.g. ethylene dibromide or propylene dibromide) provides compounds of Formula Ie wherein, for example, the moiety R¹–R² is CH₂CH₂ or CH₂CH₂CH₂.

Compounds of Formula 14 are well known in the art and are commercially available or available by well-established procedures. Amides of Formula 15 can be prepared from acids of Formula 4 or acid chlorides of Formula 3 by reaction with amines of the formula R¹NH₂ according to methods described for Schemes 2, 3 and 5.

A shown in Scheme 11a, compounds of Formula If may also be prepared by the dehydration of compounds of Formula IIc. Formula IIc compounds can be prepared from anilines with an ortho-heterocycle containing a NH moiety Formula 16) and compounds of Formula 3 in the presence of an acid scavenger according to methods described for Scheme 2. In some instances, the dehydration of IIc can occur under the coupling conditions to provide Formula If directly. See Example 3 for a more detailed example of this reaction sequence.

Benzoic acids of Formula 4, wherein J is an optionally substituted phenyl ring, are well known in the art and are commercially available or available by well-established procedures. Heterocyclic acids of Formula 4, wherein J is an optionally substituted heterocycle, can be prepared by procedures outlined in Schemes 12–35. Both general and specific references to a wide variety of heterocyclic acids including thiophenes, furans, pyridines, pyrimidines, triazoles, imidazoles, pyrazoles, thiazoles, oxazoles, isothiazoles, thiadiazoles, oxadiazoles, triazines, pyrazines, pyridazines, and isoxazoles can be found in the following compendia: Rodd's Chemistry of Chemistry of Carbon Compounds, Vol. IVa to IVl., S. Coffey editor, Elsevier Scientific Publishing, New York, 1973; Comprehensive Heterocyclic Chemistry, Vol. 1–7, A. R. Katritzky and C. W. Rees editors, Pergamon Press, New York, 1984; Comprehensive Heterocyclic Chemistry II, Vol. 1–9, A. R. Katritzky, C. W. Rees, and E. F. Scriven editors, Pergamon Press, New York, 1996; and the series, The Chemistry of Heterocyclic Compounds, E. C. Taylor, editor, Wiley, New York. Heterocyclic acids particularly useful for preparing compounds of Formula I of this invention include pyridine acids, pyrimidine acids and pyrazole acids. Procedures for the synthesis of representative examples of each are detailed in Schemes 12–35. A variety of heterocyclic acids and general methods for their synthesis may be found in PCT Patent Application Publication WO 98/57397.

Syntheses of pyrazoles of Formula 4a are described in Scheme 12. The synthesis of compounds of Formula 4a in Scheme 12 involves as the key step introduction of the R^(5a) substituent via alkylation or arylation of the pyrazole of Formula 17 with compounds of Formula 18 (wherein Lg is a leaving group as defined above). Oxidation of the methyl group affords the pyrazole carboxylic acid. Some of the more preferred R^(5b) groups include haloalkyl.

Synthesis of pyrazoles of Formula 4a is also described in Scheme 13. These acids may be prepared via metallation and carboxylation of compounds of Formula 20 as the key step. The R^(5a) group is introduced in a manner similar to that of Scheme 12, i.e. via alkylation or arylation with a compound of Formula 18. Representative R^(5b) groups include e.g. cyano, haloalkyl and halogen.

This procedure is particularly useful for preparing 1-(2-pyridinyl)pyrazolecarboxylic acids of Formula 4b (related to Preferred moiety J-6) as shown in Scheme 14. Reaction of a pyrazole of Formula 19 with a 2,3-dihalopyridine of Formula 18a affords good yields of the 1-pyridylpyrazole of Formula 20a with good specificity for the desired regiochemistry. Metallation of 20a with lithium diisopropylamide (LDA) followed by quenching of the lithium salt with carbon dioxide affords the 1-(2-pyridinyl)pyrazolecarboxylic acid of Formula 4b. See Example 1.

The synthesis of pyrazoles of Formula 4c is described in Scheme 15. They can be prepared via reaction of an optionally substituted phenyl hydrazine of Formula 21 with a ketopyruvate of Formula 22 to yield pyrazole esters of Formula 23. Hydrolysis of the esters affords the pyrazole acids of Formula 4c. This procedure is particularly useful for the preparation of compounds in which R^(5a) is optionally substituted phenyl and R^(5b) is haloalkyl.

A variation of this sequence using a furyl group as a masked carboxylic acid is described in Example 2.

An alternate synthesis of pyrazole acids of Formula 4c is described in Scheme 16. They can be prepared via 3+2 cycloaddition of an appropriately substituted nitrilimine of Formula 24 with either substituted propiolates of Formula 25 or acrylates of Formula 27. Cycloaddition with an acrylate requires additional oxidation of the intermediate pyrazoline to the pyrazole. Hydrolysis of the esters of Formula 28 affords the pyrazole acids of Formula 4c. Preferred iminohalides for this reaction include the trifluoromethyl iminochloride of Formula 29 and the iminodibromide of Formula 30. Compounds such as 29 are known (J. Heterocycl. Chem. 1985, 22(2), 565–8). Compounds such as 30 are available by known methods (Tetrahedron Letters 1999, 40, 2605). These procedures are particularly useful for the preparation of compounds where R^(5a) is optionally substituted phenyl and R^(5b) is haloalkyl or bromo.

The starting pyrazoles of Formula 19 are known compounds or can be prepared according to known methods. The pyrazole of Formula 19a (the compound of Formula 19 wherein R^(5b) is CF₃ and R^(5c) is H) is commercially available. The pyrazoles of Formula 19c (compounds of Formula 19 wherein R^(5b) is Cl or Br and R^(5c) is H) can be prepared by literature procedures (Chem. Ber. 1966, 99(10), 3350–7). A useful alternative method for the preparation of compound 19c is depicted in Scheme 17. Metallation of the sulfamoyl pyrazole of Formula 31 with n-butyllithium followed by direct halogenation of the anion with either hexachloroethane (for R^(5b) being Cl) or 1,2-dibromotetrachloroethane (for R^(5b) being Br) affords the halogenated derivatives of Formula 32. Removal of the sulfamoyl group with trifluoroacetic acid (TFA) at room temperature proceeds cleanly and in good yield to afford the pyrazoles of Formula 19c. One skilled in the art will recognize that Formula 19c is a tautomer of Formula 19b.

The synthesis of representative pyridine acids (4d) is depicted in Scheme 18. This procedure involves the known synthesis of pyridines from β-ketoesters of Formula 37 and 4-amino-butenones of Formula 36. Substituent groups R^(5a) and R^(5b) include e.g. alkyl and haloalkyl.

The synthesis of representative pyrimidine acids (4e) is depicted in Scheme 19. This procedure involves the known synthesis of pyrimidines from enamino-β-ketoesters of Formula 40 and amidines of Formula 41. Substituent groups R^(5a) and R^(5b) include e.g. alkyl and haloalkyl.

The synthesis of representative pyrazole acids of Formula 4f is depicted in Scheme 20. Reaction of a dimethylaminoylidene ketoester of Formula 45 with a substituted hydrazine (46) affords the pyrazole of Formula 47. Preferred R^(5d) substituents include alkyl and haloalkyl, with 2,2,2-trifluoroethyl especially preferred. The esters of Formula 47 are converted to the acids of Formula 4f by standard hydrolysis methods.

The synthesis of pyrazole acids of Formula 4g, which are related to the preferred moiety J-7 wherein R⁵ is a substituted 2-pyridyl moiety attached to the 5-position of the pyrazole ring, is depicted in Scheme 21. This synthesis is conducted according to the general synthesis described for Scheme 20.

The synthesis of representative pyrazole acids of Formula 4h, as well as an alternative synthesis of Formula 4f, is depicted in Scheme 22.

Reaction of the dimethylaminoylidene ketoester of Formula 45 with hydrazine affords the pyrazole of Formula 50. Reaction of the pyrazole 50 with an alkylating agent of Formula 51 affords a mixture of pyrazoles of Formulae 52 and 53. This mixture of pyrazole isomers is readily separated by chromatographic methods and converted to the corresponding acids 4h and 4f, respectively. Preferred R^(5d) substituents include alkyl and haloalkyl groups.

The synthesis of pyridinylpyrazole acids of Formula 4i, which are related to the preferred moiety J-10 wherein R⁵ is a substituted 2-pyridinyl and attached to the 3-position of the pyrazole ring, as well as an alternative synthesis of Formula 4g, is depicted in Scheme 23. This synthesis is conducted according to the general synthesis described for Scheme 22.

A general synthesis of pyrrole acids of Formula 4j is depicted in Scheme 24. Treatment of a compound of Formula 58 with 2,5-dimethoxytetrahydrofuran (59) affords a pyrrole of Formula 60. Formylation of the pyrrole 60 to provide the aldehyde of Formula 61 can be accomplished by using standard Vilsmeier-Haack formylation conditions, such as treatment with N,N-dimethylformamide (DMF) and phosphorus oxychloride. Halogenation of the compound of Formula 61 with N-halosuccinimides (NXS) such as N-chlorosuccinimide or N-bromosuccinimide occurs preferentially at the 4-position of the pyrrole ring. Oxidation of the halogenated aldehyde affords the pyrrole acid of Formula 4j. The oxidation can be accomplished by using a variety of standard oxidation conditions.

The synthesis of certain pyridinylpyrrole acids of Formula 4k, which are related to the preferred moiety J-11 wherein R⁵ is a substituted 2-pyridinyl and attached to the nitrogen of the pyrrole ring, is depicted in Scheme 25. This synthesis is conducted according to the general synthesis described for Scheme 24. The compound of Formula 58a, 3-Chloro-2-aminopyridine, is a known compound (see J. Heterocycl. Chem. 1987, 24(5), 1313–16).

The synthesis of pyrrole acids of Formula 4m is depicted in Scheme 26. Cycloaddition of an allene of Formula 69 with a phenylsulfonyl hydrazide of Formula 68 (see Pavri, N. P.; Trudell, M. L. J. Org. Chem. 1997, 62, 2649–2651) affords a pyrroline of Formula 70. Treatment of the pyrroline of Formula 70 with tetrabutylammonium fluoride (TBAF) gives a pyrrole of Formula 71. Reaction of the pyrrole 71 with an alkylating agent R^(5d)-Lg (wherein Lg is a leaving group as defined above) followed by hydrolysis affords a pyrrole acid of Formula 4m.

The synthesis of pyrrole acids of Formula 4n, which are related to the preferred moiety J-12 wherein R⁵ is a substituted phenyl or a substituted 2-pyridyl and is attached to the 2-position of the pyrrole ring, is depicted in Scheme 27. The synthesis is conducted according to the general method described for Scheme 26.

The synthesis of pyrrole acids of Formula 4o is depicted in Scheme 28. Reaction of an α,β-unsaturated ester of Formula 76 with p-tolylsulfonylmethyl isocyanide (TosMIC) provides a pyrrole of Formula 78. For a leading reference, see Xu, Z. et al, J. Org. Chem., 1988, 63, 5031–5041. Reaction of the pyrrole of Formula 78 with an alkylating agent R^(5d)-Lg (wherein Lg is a leaving group as defined above) followed by hydrolysis affords a pyrrole acid of Formula 4o.

The synthesis of pyrrole acids of Formula 4p, which are related to the preferred moiety J-13, wherein R⁵ is a substituted phenyl or a substituted 2-pyridinyl ring, is depicted in Scheme 29. The synthesis is conducted according to the general method described for Scheme 28.

Pyrazolecarboxylic acids of Formula 4q wherein R⁷ is CF₃ can be prepared by the method outlined in Scheme 30.

Reaction of a compound of Formula 81 wherein R¹² is C₁–C₄ alkyl with a suitable base in a suitable organic solvent affords the cyclized product of Formula 82 after neutralization with an acid such as acetic acid. The suitable base can be, for example but not limitation, sodium hydride, potassium t-butoxide, dimsyl sodium (CH₃S(O)CH₂ ⁻Na⁺), alkali metal (such as lithium, sodium or potassium) carbonates or hydroxides, tetraalkyl (such as methyl ethyl or butyl)ammonium fluorides or hydroxides, or 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphonine. The suitable organic solvent can be, for example but not limitation, acetone, acetonitrile, tetrahydrofuran, dichloromethane, dimethylsulfoxide, or N,N-dimethylformamide. The cyclization reaction is usually conducted in a temperature range from about 0 to 120° C. The effects of solvent, base, temperature and addition time are all interdependent, and choice of reaction conditions is important to minimize the formation of byproducts. A preferred base is tetrabutylammonium fluoride.

Dehydration of the compound of Formula 82 to give the compound of Formula 83, followed by converting the carboxylic ester function to carboxylic acid, affords the compound of Formula 4q. The dehydration is effected by treatment with a catalytic amount of a suitable acid. This catalytic acid can be, for example but not limitation, sulfuric acid. The reaction is generally conducted using an organic solvent. As one skilled in the art will realize, dehydration reactions may be conducted in a wide variety of solvents in a temperature range generally between about 0 and 200° C., more preferably between about 0 and 100° C.). For the dehydration in the method of Scheme 30, a solvent comprising acetic acid and temperatures of about 65° C. are preferred. Carboxylic ester compounds can be converted to carboxylic acid compounds by numerous methods including nucleophilic cleavage under anhydrous conditions or hydrolytic methods involving the use of either acids or bases (see T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991, pp. 224–269 for a review of methods). For the method of Scheme 30, base-catalyzed hydrolytic methods are preferred. Suitable bases include alkali metal (such as lithium, sodium or potassium) hydroxides. For example, the ester can be dissolved in a mixture of water and an alcohol such as ethanol. Upon treatment with sodium hydroxide or potassium hydroxide, the ester is saponified to provide the sodium or potassium salt of the carboxylic acid. Acidification with a strong acid, such as hydrochloric acid or sulfuric acid, yields the carboxylic acid of Formula 4q. The carboxylic acid can be isolated by methods known to those skilled in the art, including crystallization, extraction and distillation.

Compounds of Formula 81 can be prepared by the method outlined in Scheme 31.

wherein R⁷ is CF₃ and R¹² is C₁–C₄ alkyl.

Treatment of a hydrazine compound of Formula 84 with a ketone of Formula 85 in a solvent such as water, methanol or acetic acid gives the hydrazone of Formula 86. One skilled in the art will recognize that this reaction may require catalysis by an optional acid and may also require elevated temperatures depending on the molecular substitution pattern of the hydrazone of Formula 86. Reaction of the hydrazone of Formula 86 with the compound of Formula 87 in a suitable organic solvent such as, for example but not limitation, dichloromethane or tetrahydrofuran in the presence of an acid scavenger such as triethylamine provides the compound of Formula 81. The reaction is usually conducted at a temperature between about 0 and 100° C. Hydrazine compounds of Formula 84 can be prepared by standard methods, such as by contacting the corresponding halo compound of Formula 18a (Scheme 14) with hydrazine.

Pyrazolecarboxylic acids of Formula 4r wherein R⁷ is Cl or Br can be prepared by the method outlined in Scheme 32.

wherein R⁷ is Cl or Br and R¹² is C₁–C₄ alkyl.

Oxidization of the compound of Formula 88 optionally in the presence of acid to give the compound of Formula 89 followed by conversion of the carboxylic ester function to the carboxylic acid provides the compound of Formula 4r. The oxidizing agent can be hydrogen peroxide, organic peroxides, potassium persulfate, sodium persulfate, ammonium persulfate, potassium monopersulfate (e.g., Oxone®) or potassium permanganate. To obtain complete conversion, at least one equivalent of oxidizing agent versus the compound of Formula 88 should be used, preferably between about one to two equivalents. This oxidation is typically carried out in the presence of a solvent. The solvent can be an ether, such as tetrahydrofuran, p-dioxane and the like, an organic ester, such as ethyl acetate, dimethyl carbonate and the like, or a polar aprotic organic such as N,N-dimethylformamide, acetonitrile and the like. Acids suitable for use in the oxidation step include inorganic acids, such as sulfuric acid, phosphoric acid and the like, and organic acids, such as acetic acid, benzoic acid and the like. The acid, when used, should be used in greater than 0.1 equivalents versus the compound of Formula 88. To obtain complete conversion, one to five equivalents of acid can be used. The preferred oxidant is potassium persulfate and the oxidation is preferably carried out in the presence of sulfuric acid. The reaction can be carried out by mixing the compound of Formula 88 in the desired solvent and, if used, the acid. The oxidant can then be added at a convenient rate. The reaction temperature is typically varied from as low as about 0° C. up to the boiling point of the solvent in order to obtain a reasonable reaction time to complete the reaction, preferably less than 8 hours. The desired product, a compound of Formula 89 can be isolated by methods known to those skilled in the art, including crystallization, extraction and distillation. Methods suitable for converting the ester of Formula 89 to the carboxylic acid of Formula 4r are already described for Scheme 30.

Compounds of Formula 88 can be prepared from corresponding compounds of Formula 90 as shown in Scheme 33.

wherein R⁷ is Cl or Br and R¹² is C₁–C₄ alkyl.

Treatment of a compound of Formula 90 with a halogenating reagent, usually in the presence of a solvent, affords the corresponding halo compound of Formula 88. Halogenating reagents that can be used include phosphorus oxyhalides, phosphorus trihalides, phosphorus pentahalides, thionyl chloride, dihalotrialkylphophoranes, dihalodiphenylphosphoranes, oxalyl chloride and phosgene. Preferred are phosphorus oxyhalides and phosphorus pentahalides. To obtain complete conversion, at least 0.33 equivalents of phosphorus oxyhalide versus the compound of Formula 90 should be used, preferably between about 0.33 and 1.2 equivalents. To obtain complete conversion, at least 0.20 equivalents of phosphorus pentahalide versus the compound of Formula 90 should be used, preferably between about 0.20 and 1.0 equivalents. Compounds of Formula 90 wherein R¹² is C₁–C₄ alkyl are preferred for this reaction. Typical solvents for this halogenation include halogenated alkanes, such as dichloromethane, chloroform, chlorobutane and the like, aromatic solvents, such as benzene, xylene, chlorobenzene and the like, ethers, such as tetrahydrofuran, p-dioxane, diethyl ether, and the like, and polar aprotic solvents such as acetonitrile, N,N-dimethylformamide, and the like. Optionally, an organic base, such as triethylamine, pyridine, N,N-dimethylaniline or the like, can be added. Addition of a catalyst, such as N,N-dimethylformamide, is also an option. Preferred is the process in which the solvent is acetonitrile and a base is absent. Typically, neither a base nor a catalyst is required when acetonitrile solvent is used. The preferred process is conducted by mixing the compound of Formula 90 in acetonitrile. The halogenating reagent is then added over a convenient time, and the mixture is then held at the desired temperature until the reaction is complete. The reaction temperature is typically between 20° C. and the boiling point of acetonitrile, and the reaction time is typically less than two hours. The reaction mass is then neutralized with an inorganic base, such as sodium bicarbonate, sodium hydroxide and the like, or an organic base, such as sodium acetate. The desired product, a compound of Formula 88, can be isolated by methods known to those skilled in the art, including crystallization, extraction and distillation.

Alternatively, compounds of Formula 88 wherein R⁷ is Br or Cl can be prepared by treating the corresponding compounds of Formula 88 wherein R⁷ is a different halogen (e.g., Cl for making Formula 88 wherein R⁷ is Br) or a sulfonate group such as p-toluenesulfonate with hydrogen bromide or hydrogen chloride, respectively. By this method the R⁷ halogen or sulfonate substituent on the Formula 88 starting compound is replaced with Br or Cl from hydrogen bromide or hydrogen chloride, respectively. The reaction is conducted in a suitable solvent such as dibromomethane, dichloromethane or acetonitrile. The reaction can be conducted at or near atmospheric pressure or above atmospheric pressure in a pressure vessel. When R⁷ in the starting compound of Formula 88 is a halogen such as Cl, the reaction is preferably conducted in such a way that the hydrogen halide generated from the reaction is removed by sparging or other suitable means. The reaction can be conducted between about 0 and 100° C., most conveniently near ambient temperature (e.g., about 10 to 40° C.), and more preferably between about 20 and 30° C. Addition of a Lewis acid catalyst (such as aluminum tribromide for preparing Formula 88 wherein R⁷ is Br) can facilitate the reaction. The product of Formula 88 is isolated by the usual methods known to those skilled in the art, including extraction, distillation and crystallization.

Starting compounds of Formula 88 wherein R⁷ is Cl or Br can be prepared from corresponding compounds of Formula 90 as already described. Starting compounds of Formula 88 wherein R⁷ is a sulfonate group can likewise be prepared from corresponding compounds of Formula 90 by standard methods such as treatment with a sulfonyl chloride (e.g., p-toluenesulfonyl chloride) and base such as a tertiary amine (e.g., triethylamine) in a suitable solvent such as dichloromethane.

Pyrazolecarboxylic acids of Formula 4s wherein R⁷ is OCH₂CF₃ or Formula 4t wherein R⁷ is OCHF₂ can be prepared by the method outlined in Scheme 34. In this method, instead of being halogenated as shown in Scheme 33, the compound of Formula 90 is oxidized to the compound of Formula 91. The reaction conditions for this oxidation are as already described for the conversion of the compound of Formula 88 to the compound of Formula 89 in Scheme 32.

The compound of Formula 91 is then alkylated to form the compound of Formula 93 (R⁷ is OCH₂CF₃) by contact with an alkylating agent CF₃CH₂Lg (92) in the presence of a base. In the alkylating agent 92, Lg is a nucleophilic reaction leaving group such as halogen (e.g., Br, I), OS(O)₂CH₃ (methanesulfonate), OS(O)₂CF₃, OS(O)₂Ph-p-CH₃ (p-toluenesulfonate), and the like; methanesulfonate works well. The reaction is conducted in the presence of at least one equivalent of a base. Suitable bases include inorganic bases, such as alkali metal (such as lithium, sodium or potassium) carbonates and hydroxides, and organic bases, such as triethylamine, diisopropylethylamine and 1,8-diazabicyclo[5.4.0]-undec-7-ene. The reaction is generally conducted in a solvent, which can comprise alcohols, such as methanol and ethanol, halogenated alkanes, such as dichloromethane, aromatic solvents, such as benzene, toluene and chlorobenzene, ethers, such as tetrahydrofuran, and polar aprotic solvents, such as acetonitrile, N,N-dimethylformamide, and the like. Alcohols and polar aprotic solvents are preferred for use with inorganic bases. Potassium carbonate as base and acetonitrile as solvent are preferred. The reaction is generally conducted between about 0 and 150° C., with most typically between ambient temperature and 100° C.

wherein R¹² is C₁–C₄ alkyl, and Lg is a leaving group.

The compound of Formula 91 can also be alkylated to form the compound of Formula 95 (R⁷ is OCHF₂) by contact with difluorocarbene, prepared from CHClF₂ in the presence of a base. The reaction is generally conducted in a solvent, which can comprise ethers, such as tetrahydrofuran or dioxane, and polar aprotic solvents, such as acetonitrile, N,N-dimethylformamide, and the like. The base can be selected from inorganic bases such as potassium carbonate, sodium hydroxide or sodium hydride. Preferably the reaction is conducted using potassium carbonate with N,N-dimethylformamide as the solvent. The esters of Formula 93 or 95 can be isolated by conventional techniques such as extraction. The esters can then be converted to the carboxylic acids of Formula 4 or 4t by the methods already described for the conversion of Formula 83 to Formula 4q in Scheme 30.

As outlined in Scheme 35, compounds of Formula 90 can be prepared from compounds of Formula 84 (see Scheme 31).

wherein R¹² is C₁–C₄ alkyl.

In this method, a hydrazine compound of Formula 84 is contacted with a compound of Formula 96 (a Separate ester or maleate ester or a mixture thereof may be used) in the presence of a base and a solvent. The base is typically a metal alkoxide salt, such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium tert-butoxide, lithium tert-butoxide, and the like. Greater than 0.5 equivalents of base versus the compound of Formula 84 should be used, preferably between 0.9 and 1.3 equivalents. Greater than 1.0 equivalents of the compound of Formula 96 should be used, preferably between 1.0 to 1.3 equivalents. Polar protic and polar aprotic organic solvents can be used, such as alcohols, acetonitrile, tetrahydrofuran, N,N-dimethylformamide, dimethyl sulfoxide and the like. Preferred solvents are alcohols such as methanol and ethanol. It is especially preferred that the alcohol be the same as that making up the fumarate or maleate ester and the alkoxide base. The reaction is typically conducted by mining the compound of Formula 84 and the base in the solvent. The mixture can be heated or cooled to a desired temperature and the compound of Formula 96 added over a period of time. Typically reaction temperatures are between 0° C. and the boiling point of the solvent used. The reaction may be conducted under greater than atmospheric pressure in order to increase the boiling point of the solvent. Temperatures between about 30 and 90° C. are generally preferred. The addition time can be as quick as heat transfer allows. Typical addition times are between 1 minute and 2 hours. Optimum reaction temperature and addition time vary depending upon the identities of the compounds of Formula 84 and Formula 96. After addition, the reaction mixture can be held for a time at the reaction temperature. Depending upon the reaction temperature, the required hold time may be from 0 to 2 hours. Typical hold times are 10 to 60 minutes. The reaction mass then can be acidified by adding an organic acid, such as acetic acid and the like, or an inorganic acid, such as hydrochloric acid, sulfuric acid and the like. Depending on the reaction conditions and the means of isolation, the —CO₂R¹² function on the compound of Formula 90 may be hydrolyzed to —CO₂H; for example, the presence of water in the reaction mixture can promote such hydrolysis. If the carboxylic acid (—CO₂H) is formed, it can be converted back to —CO₂R¹² wherein R¹² is C₁–C₄ alkyl using esterification methods well known in the art. The desired product, a compound of Formula 90, can be isolated by methods known to those skilled in the art, such as crystallization, extraction or distillation.

It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula I may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula I. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular sequence presented to prepare the compounds of Formula I.

It is believed that one skilled in the art using the preceding description can prepare compounds of Formula I of the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¹H NMR spectra are reported in ppm downfield from tetramethylsilane; s means singlet, d means doublet, t means triplet, q means quartet, m means multiplet, dd means doublet of doublets, dt means doublet of triplets, br s means broad singlet.

EXAMPLE 1 Preparation of N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-lidene]-2-propanamine Step A: Preparation of 3-chloro-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine

To a mixture of 2,3-dichloropyridine (99.0 g, 0.67 mol) and 3-trifluoromethyl pyrazole (83 g, 0.61 mol) in dry N,N-dimethylformamide (300 mL) was added potassium carbonate (166.0 g, 1.2 mol) and the reaction was then heated to 110–125° C. over 48 hours. The reaction was cooled to 100° C. and filtered through Celite® diatomaceous filter aid to remove solids. N,N-Dimethylformamide and excess dichloropyridine were removed by distillation at atmospheric pressure. Distillation of the product at reduced pressure (b.p. 139–141° C., 7 mm) afforded the desired intermediate as a clear yellow oil (113.4 g).

¹H NMR (CDCl₃): δ 6.78 (s, 1H), 7.36 (t, 1H), 7.93 (d, 1H), 8.15 (s, 1H), 8.45 (d, 1H)

Step B: Preparation of 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl-1H-pyrazole-5-carboxylic acid

To a solution of the pyrazole product from Step A (105.0 g, 425 mmol) in dry tetrahydrofuran (700 mL) at −75° C. was added via cannula a −30° C. solution of lithium diisopropylamide (425 mmol) in dry tetrahydrofuran (300 mL). The deep red solution was stirred for 15 minutes, after which time carbon dioxide was bubbled through at −63° C. until the solution became pale yellow and the exothermicity ceased. The reaction was stirred for an additional 20 minutes and then quenched with water (20 mL). The solvent was removed under reduced pressure, and the reaction mixture partitioned between ether and 0.5 N aqueous sodium hydroxide solution. The aqueous extracts were washed with ether (3×), filtered through Celite® diatomaceous filter aid to remove residual solids, and then acidified to a pH of approximately 4, at which point an orange oil formed. The aqueous mixture was stirred vigorously and additional acid was added to lower the pH to 2.5–3. The orange oil congealed into a granular solid, which was filtered, washed successively with water and 1N hydrochloric acid, and dried under vacuum at 50° C. to afford the title product as an off-white solid (130 g). (Product from another run following similar procedures melted at 175–176° C.)

¹H NMR (DMSO-d₆): δ 7.61 (s, 1H), 7.76 (dd, 1H), 8.31 (d, 1H), 8.60 (d, 1H).

Step C: Preparation of 8-methyl-2H-3,1-benzoxazine-2,4(1H)-dione

To a solution of 2-amino-3-methylbenzoic acid (6 g) in dry 1,4-dioxane (50 mL) was added dropwise a solution of trichloromethyl chloroformate (8 mL) in dry 1,4-dioxane (25 mL), with ice-water cooling to keep the reaction temperature below 25° C. A white precipitate began to form during the addition. The reaction mixture was stirred at room temperature overnight. The precipitated solids were removed by filtration and washed with 1,4-dioxane (2×20 mL) and hexane (2×15 mL) and air-dried to yield 6.51 g of off-white solid.

¹H NMR (DMSO-d₆) δ 2.33 (s, 3H), 7.18 (t, 1H), 7.59 (d, 1H), 7.78 (d, 1H), 11.0 (br s, 1H).

Step D: Preparation of 1-(3-chloro-2-pyridinyl)-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

To a solution of the carboxylic acid product prepared as in Step B (28 g, 96 mmol) in dichloromethane (240 mL) was added N,N-dimethylformamide (12 drops) and oxalyl chloride (15.8 g, 124 mmol). The reaction mixture was stirred at room temperature until gas evolution ceased (approximately 1.5 hours). The reaction mixture was concentrated in vacuo to provide the crude acid chloride as an oil that was used without further purification. The crude acid chloride was dissolved in acetonitrile (95 mL) and added to a solution of the benzoxazin-2,4-dione prepared as in Step C in acetonitrile (95 mL). The resulting mixture was stirred at room temperature (approximately 30 minutes). Pyridine (95 mL) was added and the mixture heated to about 90° C. (approximately 1 hour). The reaction mixture was cooled to about 35° C. and isopropylamine (25 mL) was added. The reaction mixture exothermically warmed during the addition and then was maintained at about 50° C. (approximately 1 hour). The reaction mixture was then poured into ice water and stirred. The resulting precipitate was collected by filtration, washed with water and dried in vacuo overnight to provide 37.5 g of the title compound as a tan solid.

¹H NMR (CDCl₃): δ 1.23 (d, 6H), 2.21 (s, 3H), 4.2 (m, 1H), 5.9 (d, 1H), 7.2 (t, 1H), 7.3 (m, 2H), 7.31 (s, 1H), 7.4 (m, 1H), 7.8 (d, 1H), 8.5 (d, 1H), 10.4 (s, 1H).

Step E: Preparation of N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine

A stirred solution of the title compound from Step D (1.2 g, 2.6 mmol) in 8 mL of phosphorous oxychloride was heated at reflux for 8 hours. The hot reaction solution was poured onto a large excess of ice and 100 ml of ethyl acetate added almost immediately (before allowing all of the ice to melt). After stirring and allowing the remaining ice to melt, the ethyl acetate layer was separated, washed with water, aqueous saturated sodium bicarbonate and brine. Followed by drying over magnesium sulfate, the solvent was removed in vacuo to give a crude yellow oily solid residue. Purification by flash chromatography on silica gel (4:1 hexane/ethyl acetate as eluant) afforded 450 mg of the title compound, a compound of the invention, isolated as a white solid melting at 175–176° C.

¹H NMR (CDCl₃): δ 1.23 (d, 6H), 1.75 (s, 3H), 4.07 (m, 1H), 7.15–7.28 (m, 3H), 7.45 (m, 1H), 7.90 (d, 1H), 7.95 (d, 1H), 8.55 (d, 1H).

EXAMPLE 2 Preparation of N-[2-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine Step A: Preparation of 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

To a solution of 1-(2-furyl)-4,4,4-trifluorobutane-1,3-dione (105 g, 0.51 mole) in glacial acetic acid (220 mL) was added sodium acetate (42 g 0.51 mole). The temperature rose to about 34° C. 2-Chlorophenylhydrazine hydrochloride (90 g, 0.5 mole) was added portionwise over a period of 10 minutes to give a creamy suspension. The mixture was warmed to about 60° C. for about 45 minutes. The bulk of the acetic acid was removed by stripping on a rotary evaporator at a bath temperature of 65° C. The remaining oily residue was added to about 800 ml of water with vigorous stirring and a heterogeneous mixture resulted. After about 15 minutes, dichloromethane (500 mL) was added and the mixture was partitioned. The aqueous phase was extracted with 300 ml of dichloromethane. The combined organic phases were washed with water and saturated sodium bicarbonate solution and then dried with MgSO₄ and filtered. Volatiles were removed on a rotary evaporator. The crude product consisted of 151 g of a dark red oil, which contained approximately 89% of the desired product and 11% of the regioisomeric pyrazole (determined by NMR analysis).

Step B: Preparation of 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

A sample of the crude product from Step A (approximately 89%, 56.0 g, 0.18 mole) was dissolved in acetonitrile (400 mL) and a solution of NaH₂PO₄ (120 g, 0.87 mole) in 520 mL of water was added. Sodium hypochlorite solution (5.25% in water, 128 g, 2.6 mole) was added dropwise over 10–15 minutes. The orange solution was maintained at room temperature for 30 minutes. The reaction mixture was cooled in an ice bath and a solution of NaClO₂ in 560 mL of water was added dropwise, keeping the temperature below 11° C. Gas evolution was observed and an aqueous sodium hydroxide scrubber was used to quench evolved chlorine. After the addition was complete, the reaction mixture was kept cold for one hour then allowed to reach room temperature overnight. To the reaction mixture was added 80 mL of concentrated hydrochloric acid dropwise to bring the pH below 3. The reaction mixture was extracted twice with ethyl acetate and the combined organic extracts were added dropwise rapidly with stirring to a cooled (<15° C.) solution of 300 g of NAHSO₃ in 1300 mL of water. The mixture was partitioned and the aqueous phase extracted with ethyl acetate. The combined organic phases were washed with saturated brine, dried (MgSO₄), filtered and concentrated in vacuo. The residue was taken up in chlorobutane and reconcentrated (twice). The resulting brown solid was titurated in 100 mL of ethyl ether in hexane (1%). Small portions of chlorobutane were added to help granulate the solid. The product was collected via filtration, washed with hexanes and dried. The product consisted of 40.8 g of tan solid, which was essentially pure based upon ¹H NMR.

Step C: Preparation of 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

A sample of crude 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (40.8 g, 0.14 mole) was dissolved in methylene chloride (300 mL). The solution was treated with oxalyl chloride (15.7 mL, 0.18 mole), followed by N,N-dimethylformamide (12 drops). Off-gassing began shortly after adding the N,N-dimethylformamide catalyst. The reaction mixture was stirred for about 20 minutes under ambient conditions, then was heated to reflux for a period of 35 minutes. Volatiles were removed by concentrating the reaction mixture on a rotary evaporator at a bath temperature of 55° C. The crude product, approximately 43 g of a light-yellow oil, was used directly in the next step.

Step D: Preparation of 1-(2-chlorophenyl)-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

To a sample of the title compound of Example 1, Step C (22.3 g, 0.126 mole), suspended in acetonitrile (100 mL) was added crude 1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride (43 g). The mixture was diluted with 350 mL of pyridine and heated to approximately 95° C. for a period of 2 hours. The mixture was cooled to 29° C., then was treated with isopropylamine (32.2 mL, 0.38 mole). The reaction mass self-heated to 60° C. and was maintained at about 50° C. for one hour, then stirred overnight. The reaction mixture was poured into 1 L of water and stirred. The resulting solid was collected by filtration and washed with water. The wet cake was taken up in a mixture of dichloromethane and methanol, the water removed, and the organic phase was dried with molecular sieves and filtered. Volatiles were removed on a rotary evaporator. The crude product was triturated with 1:1 ether/hexane, collected by filtration and washed with hexanes to yield 42.6 g of a light tan solid melting at 230–231° C.

¹H NMR (DMSO-d₆) δ 10.3 (s, 1H), 7.1–7.5 (m, 8H), 5.9 (d, 1H), 4.2 (m, 1H), 2.21 (s, 3H), 1.21 (d, 6H).

Step E Preparation of N-[2-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine

To the title compound of Step D (1.2 g, 2.7 mmol) dissolved in 8 mL of dichloromethane, 5 mL of thionyl chloride was added and the solution heated at reflux for 8 hours. The solvent was removed in vacuo aid remaining residue partitioned between 70 mL of ethyl acetate and water. The organic layer was separated, washed with water, saturated aqueous sodium bicarbonate and brine. The organic phase was dried over magnesium sulfate and the solvent was removed in vacuo to give a crude oily solid residue. Purification by flash chromatography on silica gel (2:1 hexane/ethyl acetate) and filtering from hexane afforded 700 mg of the title compound, a compound of the invention, isolated as a white solid melting at 133–135° C.

¹H NMR (CDCl₃): δ 7.90 (d, 1H), 7.57–7.43 (m, 4H), 7.30–7.13 (m, 3H), 4.0 (m, 1H), 1.80 (s, 3H), 1.21 (d, 61).

EXAMPLE 3 Preparation of 7,9-Dichloro-5-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2,3-dihydroimidazo[1,2-c]quinazoline Step A: Preparation of 2.4-Dichloro-6-(4,5-dihydro-1H-imidazol-2-yl)benzenamine

To a solution of ethylene diamine (1.2 mL, 18 mmol) in ethyl ether (50 mL) at −20° C. was added n-butyl lithium (6.4 mL, 2.5 M in hexanes, 16 mmol). The mixture was stirred at 0° C. for 0.3 hour before the addition of 2,4-dichloro-6-trifluoromethyl aniline (0.92 g, 4.2 mmol). The mixture was stirred at 0° C. for an additional 1.5 hours, at which point water (0.36 mL, 20 mmol) was added and the solvent was removed under reduced pressure. Purification by flash column chromatography (silica gel, 1% to 10% methanol in dichloromethane) to give the title compound of Step A (0.35 g) as a yellow solid.

¹H NMR(CDCl₃) δ 7.30 (d, 1H), 7.23 (d, 1H), 6.8 (bs, 2H), 4.7–4.6 (bs, 1H), 3.77 (bs, 4H).

Step B: Preparation of 7,9-Dichloro-5-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2,3-dihydroimidazo[1,2-c]quinazoline

To a solution of 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (0.6 g, 2.02 mol) (see Example 1, Step B) in dichloromethane (10 mL) containing dimethylformamide (1 drop) was added oxalyl chloride (198 μL, 2.22 mmol). The mixture was stirred at ambient temperature for two hours before being concentrated under reduced pressure and redissolved in dichloromethane (5 mL). Seven tenths of this solution was added to a solution of the title compound of Step A (0.3 g, 1.3 mmol), triethylamine (272 mL, 1.95 mmol) and dimethylamniopyridine (16 mg, 0.13 mmol) in dichlorometane (5 mL) and the mixture was stirred at ambient temperature overnight. A saturated solution of sodium bicarbonate was then added and the mixture was filtered through a column of Celite®. Concentration of the filtrate provided material that was purified using flash column chromatography (silica gel, 1% then 2% then 5% methanol in dichloromethane then again in 10% then 20% acetone in chloroform then 5% methanol in dichloromethane). Isolation of the first-eluting material gave the title compound of Example 3, a compound of the invention, as a yellow solid (62 mg). A second-eluting material (31 mg) was 1-(3-Chloro-2-pyridinyl)-N-[2,4-dichloro-6-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, the precursor to Example 3.

¹H NMR (CDCl₃) δ 8.5–8.4 (d, 1H), 7.9 (d, 1H), 7.46 (d, 1H), 7.41 (d, 1H), 7.4 (dd, 1H), 7.31 (s, 1H), 3.77 (s, 4H).

By the procedures described herein together with methods known in the art, the following compounds of Tables 1–21 can be prepared. The following abbreviations are used in the Tables which follow: t means tertiary, s means secondary, n means normal, i means iso, Me means methyl, Et means ethyl, Pr means propyl i-Pr means isopropyl and Bu means butyl.

TABLE 1

R^(5b) is CF₃ R^(5b) is OCF₃ R^(5b) is CF(CF₃)₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 2

R^(5b) is CF₃ R^(5b) is OCF₃ R^(5b) is CF(CF₃)₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 3

R^(5b) is CF₃ R^(5b) is OCF₃ R^(5b) is CF(CF₃)₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 4

R^(5b) is CF₃ R^(5b) is OCF₃ R^(5b) is CF(CF₃)₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 5

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl H Cl Br Me Cl Br Cl Br Et CH₃ H CF₃ Cl Et Cl H Cl Br Et Cl Br Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl H Cl Br i-Pr Cl Br Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl H Cl Br t-Bu Cl Br Cl Br Me CH₃ H CF₃ Br Me Cl H Br Cl Me Cl Br Br Cl Et CH₃ H CF₃ Br Et Cl H Br Cl Et Cl Br Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl H Br Cl i-Pr Cl Br Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl H Br Cl t-Bu Cl Br Br Cl Me CH₃ H Cl Cl Me Cl H Br Br Me Cl Br Br Br Et CH₃ H Cl Cl Et Cl H Br Br Et Cl Br Br Br i-Pr CH₃ H Cl Cl i-Pr Cl H Br Br i-Pr Cl Br Br Br t-Bu CH₃ H Cl Cl t-Bu Cl H Br Br t-Bu Cl Br Br Br Me CH₃ H Cl Br Me Cl H CF₃ Cl Me Cl I CF₃ Cl Et CH₃ H Cl Br Et Cl H CF₃ Cl Et Cl I CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl H CF₃ Cl i-Pr Cl I CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl H CF₃ Cl t-Bu Cl I CF₃ Cl Me CH₃ H Br Cl Me Cl H CF₃ Br Me Cl I CF₃ Br Et CH₃ H Br Cl Et Cl H CF₃ Br Et Cl I CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl H CF₃ Br i-Pr Cl I CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl H CF₃ Br t-Bu Cl I CF₃ Br Me CH₃ H Br Br Me Cl H Cl Cl Me Cl I Cl Cl Et CH₃ H Br Br Et Cl H Cl Cl Et Cl I Cl Cl i-Pr CH₃ H Br Br i-Pr Cl H Cl Cl i-Pr Cl I Cl Cl t-Bu CH₃ H Br Br i-Pr Cl H Cl Cl t-Bu Cl I Cl Cl Me CH₃ F CF₃ Cl Me CH₃ Cl CF₃ Cl Me Cl I Cl Br Et CH₃ F CF₃ Cl Et CH₃ Cl CF₃ Cl Et Cl I Cl Br i-Pr CH₃ F CF₃ Cl i-Pr CH₃ Cl CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ F CF₃ Cl t-Bu CH₃ Cl CF₃ Cl t-Bu Cl I Cl Br Me CH₃ F CF₃ Br Me CH₃ Cl CF₃ Br Me Cl I Br Cl Et CH₃ F CF₃ Br Et CH₃ Cl CF₃ Br Et Cl I Br Cl i-Pr CH₃ F CF₃ Br i-Pr CH₃ Cl CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ F CF₃ Br t-Bu CH₃ Cl CF₃ Br t-Bu Cl I Br Cl Me CH₃ F Cl Cl Me CH₃ Cl Cl Cl Me Cl I Br Br Et CH₃ F Cl Cl Et CH₃ Cl Cl Cl Et Cl I Br Br i-Pr CH₃ F Cl Cl i-Pr CH₃ Cl Cl Cl i-Pr Cl I Br Br t-Bu CH₃ F Cl Cl t-Bu CH₃ Cl Cl Cl t-Bu Cl I Br Br Me CH₃ F Cl Br Me CH₃ Cl Cl Br Me Cl CF₃ CF₃ Cl Et CH₃ F Cl Br Et CH₃ Cl Cl Br Et Cl CF₃ CF₃ Cl i-Pr CH₃ F Cl Br i-Pr CH₃ Cl Cl Br i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ F Cl Br t-Bu CH₃ Cl Cl Br t-Bu Cl CF₃ CF₃ Cl Me CH₃ F Br Cl Me CH₃ Cl Br Cl Me Cl CF₃ CF₃ Br Et CH₃ F Br Cl Et CH₃ Cl Br Cl Et Cl CF₃ CF₃ Br i-Pr CH₃ F Br Cl i-Pr CH₃ Cl Br Cl i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ F Br Cl t-Bu CH₃ Cl Br Cl t-Bu Cl CF₃ CF₃ Br Me CH₃ F Br Br Me CH₃ Cl Br Br Me Cl CF₃ Cl Cl Et CH₃ F Br Br Et CH₃ Cl Br Br Et Cl CF₃ Cl Cl i-Pr CH₃ F Br Br i-Pr CH₃ Cl Br Br i-Pr Cl CF₃ Cl Cl t-Bu CH₃ F Br Br t-Bu CH₃ Cl Br Br t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Cl F CF₃ Cl Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Cl F CF₃ Cl Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Cl F CF₃ Br Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Cl F CF₃ Br Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Cl F Cl Cl Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Cl F Cl Cl Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Cl F Cl Cl i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Cl F Cl Cl t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Cl F Cl Br n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Cl F Cl Br n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Cl F Cl Br s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Cl F Cl Br i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Cl F Br Cl Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Cl F Br Cl Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Cl F Br Cl i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Cl F Br Cl t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Cl F Br Br Me Br F CF₃ Br Et CH₃ Br Br Br Et Cl F Br Br Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Cl F Br Br i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Cl F Br Br t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Cl Cl CF₃ Cl Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Cl Cl CF₃ Cl Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Cl Cl CF₃ Br Me Br F Cl Br Et CH₃ I CF₃ Br Et Cl Cl CF₃ Br Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Cl Cl Cl Cl Me Br F Br Cl Et CH₃ I Cl Cl Et Cl Cl Cl Cl Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Cl Cl Cl Cl i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Cl Cl Cl Cl t-Bu Br F Br Cl Me CH₃ I Cl Br Me Cl Cl Cl Br Me Br F Br Br Et CH₃ I Cl Br Et Cl Cl Cl Br Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Cl Cl Cl Br i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Cl Cl Cl Br t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ CF₃ Cl Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ CF₃ Cl Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ CF₃ Cl i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ CF₃ Cl t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br CF₃ CF₃ Br Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br CF₃ CF₃ Br Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br CF₃ CF₃ Br i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br CF₃ CF₃ Br t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br CF₃ Cl Cl Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br CF₃ Cl Cl Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br CF₃ Cl Cl i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br CF₃ Cl Cl t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br CF₃ Cl Br Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br CF₃ Cl Br Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br CF₃ Cl Br i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br CF₃ Cl Br t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br CF₃ Br Cl Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br CF₃ Br Cl Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br CF₃ Br Cl i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br CF₃ Br Cl t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me Br CF₃ Br Br Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et Br CF₃ Br Br Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr Br CF₃ Br Br i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu Br CF₃ Br Br t-Bu Br Cl Br Br Me CH₃ CF₃ Br Cl Me Br I CF₃ Cl Me Br Br CF₃ Cl Et CH₃ CF₃ Br Cl Et Br I CF₃ Cl Et Br Br CF₃ Cl i-Pr CH₃ CF₃ Br Cl i-Pr Br I CF₃ Cl i-Pr Br Br CF₃ Cl t-Bu CH₃ CF₃ Br Cl t-Bu Br I CF₃ Cl t-Bu Br Br CF₃ Cl Me CH₃ CF₃ Br Br Me Br I CF₃ Br Me Br Br CF₃ Br Et CH₃ CF₃ Br Br Et Br I CF₃ Br Et Br Br CF₃ Br i-Pr CH₃ CF₃ Br Br i-Pr Br I CF₃ Br i-Pr Br Br CF₃ Br t-Bu CH₃ CF₃ Br Br t-Bu Br I CF₃ Br t-Bu Br Br CF₃ Br n-Pr CH₃ Cl Cl Cl Me Br I Cl Cl Me Br Br Cl Cl n-Bu CH₃ Cl Cl Cl Et Br I Cl Cl Et Br Br Cl Cl s-Bu CH₃ Cl Cl Cl i-Pr Br I Cl Cl i-Pr Br Br Cl Cl i-Bu CH₃ Cl Cl Cl t-Bu Br I Cl Cl t-Bu Br Br Cl Cl Me Cl Cl Br Cl Me Br I Cl Br Me Br Br Cl Br Et Cl Cl Br Cl Et Br I Cl Br Et Br Br Cl Br i-Pr Cl Cl Br Cl i-Pr Br I Cl Br i-Pr Br Br Cl Br t-Bu Cl Cl Br Cl t-Bu Br I Cl Br t-Bu Br Br Cl Br Me Cl Cl Br Br Me Br I Br Cl Me Br Br Br Cl Et Cl Cl Br Br Et Br I Br Cl Et Br Br Br Cl i-Pr Cl Cl Br Br i-Pr Br I Br Cl i-Pr Br Br Br Cl t-Bu Cl Cl Br Br t-Bu Br I Br Cl t-Bu Br Br Br Cl Me Cl Br CF₃ Cl Me Br I Br Br Me Br Br Br Br Et Cl Br CF₃ Cl Et Br I Br Br Et Br Br Br Br i-Pr Cl Br CF₃ Cl i-Pr Br I Br Br i-Pr Br Br Br Br t-Bu Cl Br CF₃ Cl t-Bu Br I Br Br t-Bu Br Br Br Br Me Cl Br CF₃ Br Me Cl Br Cl Cl t-Bu Cl Br CF₃ Br Et Cl Br CF₃ Br Et Cl Br Cl Cl t-Bu Cl Br Cl Cl i-Pr Cl Br CF₃ Br i-Pr Cl Br Cl Cl

TABLE 6

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl H Cl Br Me Cl Br Cl Br Et CH₃ H CF₃ Cl Et Cl H Cl Br Et Cl Br Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl H Cl Br i-Pr Cl Br Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl H Cl Br t-Bu Cl Br Cl Br Me CH₃ H CF₃ Br Me Cl H Br Cl Me Cl Br Br Cl Et CH₃ H CF₃ Br Et Cl H Br Cl Et Cl Br Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl H Br Cl i-Pr Cl Br Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl H Br Cl t-Bu Cl Br Br Cl Me CH₃ H Cl Cl Me Cl H Br Br Me Cl Br Br Br Et CH₃ H Cl Cl Et Cl H Br Br Et Cl Br Br Br i-Pr CH₃ H Cl Cl i-Pr Cl H Br Br i-Pr Cl Br Br Br t-Bu CH₃ H Cl Cl t-Bu Cl H Br Br t-Bu Cl Br Br Br Me CH₃ H Cl Br Me Cl H CF₃ Cl Me Cl I CF₃ Cl Et CH₃ H Cl Br Et Cl H CF₃ Cl Et Cl I CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl H CF₃ Cl i-Pr Cl I CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl H CF₃ Cl t-Bu Cl I CF₃ Cl Me CH₃ H Br Cl Me Cl H CF₃ Br Me Cl I CF₃ Br Et CH₃ H Br Cl Et Cl H CF₃ Br Et Cl I CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl H CF₃ Br i-Pr Cl I CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl H CF₃ Br t-Bu Cl I CF₃ Br Me CH₃ H Br Br Me Cl H Cl Cl Me Cl I Cl Cl Et CH₃ H Br Br Et Cl H Cl Cl Et Cl I Cl Cl i-Pr CH₃ H Br Br i-Pr Cl H Cl Cl i-Pr Cl I Cl Cl t-Bu CH₃ H Br Br i-Pr Cl H Cl Cl t-Bu Cl I Cl Cl Me CH₃ F CF₃ Cl Me CH₃ Cl CF₃ Cl Me Cl I Cl Br Et CH₃ F CF₃ Cl Et CH₃ Cl CF₃ Cl Et Cl I Cl Br i-Pr CH₃ F CF₃ Cl i-Pr CH₃ Cl CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ F CF₃ Cl t-Bu CH₃ Cl CF₃ Cl t-Bu Cl I Cl Br Me CH₃ F CF₃ Br Me CH₃ Cl CF₃ Br Me Cl I Br Cl Et CH₃ F CF₃ Br Et CH₃ Cl CF₃ Br Et Cl I Br Cl i-Pr CH₃ F CF₃ Br i-Pr CH₃ Cl CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ F CF₃ Br t-Bu CH₃ Cl CF₃ Br t-Bu Cl I Br Cl Me CH₃ F Cl Cl Me CH₃ Cl Cl Cl Me Cl I Br Br Et CH₃ F Cl Cl Et CH₃ Cl Cl Cl Et Cl I Br Br i-Pr CH₃ F Cl Cl i-Pr CH₃ Cl Cl Cl i-Pr Cl I Br Br t-Bu CH₃ F Cl Cl t-Bu CH₃ Cl Cl Cl t-Bu Cl I Br Br Me CH₃ F Cl Br Me CH₃ Cl Cl Br Me Cl CF₃ CF₃ Cl Et CH₃ F Cl Br Et CH₃ Cl Cl Br Et Cl CF₃ CF₃ Cl i-Pr CH₃ F Cl Br i-Pr CH₃ Cl Cl Br i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ F Cl Br t-Bu CH₃ Cl Cl Br t-Bu Cl CF₃ CF₃ Cl Me CH₃ F Br Cl Me CH₃ Cl Br Cl Me Cl CF₃ CF₃ Br Et CH₃ F Br Cl Et CH₃ Cl Br Cl Et Cl CF₃ CF₃ Br i-Pr CH₃ F Br Cl i-Pr CH₃ Cl Br Cl i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ F Br Cl t-Bu CH₃ Cl Br Cl t-Bu Cl CF₃ CF₃ Br Me CH₃ F Br Br Me CH₃ Cl Br Br Me Cl CF₃ Cl Cl Et CH₃ F Br Br Et CH₃ Cl Br Br Et Cl CF₃ Cl Cl i-Pr CH₃ F Br Br i-Pr CH₃ Cl Br Br i-Pr Cl CF₃ Cl Cl t-Bu CH₃ F Br Br t-Bu CH₃ Cl Br Br t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Cl F CF₃ Cl Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Cl F CF₃ Cl Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Cl F CF₃ Br Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Cl F CF₃ Br Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Cl F Cl Cl Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Cl F Cl Cl Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Cl F Cl Cl i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Cl F Cl Cl t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Cl F Cl Br n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Cl F Cl Br n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Cl F Cl Br s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Cl F Cl Br i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Cl F Br Cl Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Cl F Br Cl Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Cl F Br Cl i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Cl F Br Cl t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Cl F Br Br Me Br F CF₃ Br Et CH₃ Br Br Br Et Cl F Br Br Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Cl F Br Br i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Cl F Br Br t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Cl Cl CF₃ Cl Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Cl Cl CF₃ Cl Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Cl Cl CF₃ Br Me Br F Cl Br Et CH₃ I CF₃ Br Et Cl Cl CF₃ Br Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Cl Cl Cl Cl Me Br F Br Cl Et CH₃ I Cl Cl Et Cl Cl Cl Cl Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Cl Cl Cl Cl i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Cl Cl Cl Cl t-Bu Br F Br Cl Me CH₃ I Cl Br Me Cl Cl Cl Br Me Br F Br Br Et CH₃ I Cl Br Et Cl Cl Cl Br Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Cl Cl Cl Br i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Cl Cl Cl Br t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ CF₃ Cl Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ CF₃ Cl Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ CF₃ Cl i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ CF₃ Cl t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br CF₃ CF₃ Br Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br CF₃ CF₃ Br Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br CF₃ CF₃ Br i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br CF₃ CF₃ Br t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br CF₃ Cl Cl Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br CF₃ Cl Cl Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br CF₃ Cl Cl i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br CF₃ Cl Cl t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br CF₃ Cl Br Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br CF₃ Cl Br Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br CF₃ Cl Br i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br CF₃ Cl Br t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br CF₃ Br Cl Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br CF₃ Br Cl Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br CF₃ Br Cl i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br CF₃ Br Cl t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me Br CF₃ Br Br Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et Br CF₃ Br Br Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr Br CF₃ Br Br i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu Br CF₃ Br Br t-Bu Br Cl Br Br Me CH₃ CF₃ Br Cl Me Br I CF₃ Cl Me Br Br CF₃ Cl Et CH₃ CF₃ Br Cl Et Br I CF₃ Cl Et Br Br CF₃ Cl i-Pr CH₃ CF₃ Br Cl i-Pr Br I CF₃ Cl i-Pr Br Br CF₃ Cl t-Bu CH₃ CF₃ Br Cl t-Bu Br I CF₃ Cl t-Bu Br Br CF₃ Cl Me CH₃ CF₃ Br Br Me Br I CF₃ Br Me Br Br CF₃ Br Et CH₃ CF₃ Br Br Et Br I CF₃ Br Et Br Br CF₃ Br i-Pr CH₃ CF₃ Br Br i-Pr Br I CF₃ Br i-Pr Br Br CF₃ Br t-Bu CH₃ CF₃ Br Br t-Bu Br I CF₃ Br t-Bu Br Br CF₃ Br n-Pr CH₃ Cl Cl Cl Me Br I Cl Cl Me Br Br Cl Cl n-Bu CH₃ Cl Cl Cl Et Br I Cl Cl Et Br Br Cl Cl s-Bu CH₃ Cl Cl Cl i-Pr Br I Cl Cl i-Pr Br Br Cl Cl i-Bu CH₃ Cl Cl Cl t-Bu Br I Cl Cl t-Bu Br Br Cl Cl Me Cl Cl Br Cl Me Br I Cl Br Me Br Br Cl Br Et Cl Cl Br Cl Et Br I Cl Br Et Br Br Cl Br i-Pr Cl Cl Br Cl i-Pr Br I Cl Br i-Pr Br Br Cl Br t-Bu Cl Cl Br Cl t-Bu Br I Cl Br t-Bu Br Br Cl Br Me Cl Cl Br Br Me Br I Br Cl Me Br Br Br Cl Et Cl Cl Br Br Et Br I Br Cl Et Br Br Br Cl i-Pr Cl Cl Br Br i-Pr Br I Br Cl i-Pr Br Br Br Cl t-Bu Cl Cl Br Br t-Bu Br I Br Cl t-Bu Br Br Br Cl Me Cl Br CF₃ Cl Me Br I Br Br Me Br Br Br Br Et Cl Br CF₃ Cl Et Br I Br Br Et Br Br Br Br i-Pr Cl Br CF₃ Cl i-Pr Br I Br Br i-Pr Br Br Br Br t-Bu Cl Br CF₃ Cl t-Bu Br I Br Br t-Bu Br Br Br Br Me Cl Br CF₃ Br Me Cl Br Cl Cl t-Bu Cl Br CF₃ Br Et Cl Br CF₃ Br Et Cl Br Cl Cl t-Bu Cl Br Cl Cl i-Pr Cl Br CF₃ Br i-Pr Cl Br Cl Cl

TABLE 7

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl H Cl Br Me Cl Br Cl Br Et CH₃ H CF₃ Cl Et Cl H Cl Br Et Cl Br Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl H Cl Br i-Pr Cl Br Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl H Cl Br t-Bu Cl Br Cl Br Me CH₃ H CF₃ Br Me Cl H Br Cl Me Cl Br Br Cl Et CH₃ H CF₃ Br Et Cl H Br Cl Et Cl Br Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl H Br Cl i-Pr Cl Br Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl H Br Cl t-Bu Cl Br Br Cl Me CH₃ H Cl Cl Me Cl H Br Br Me Cl Br Br Br Et CH₃ H Cl Cl Et Cl H Br Br Et Cl Br Br Br i-Pr CH₃ H Cl Cl i-Pr Cl H Br Br i-Pr Cl Br Br Br t-Bu CH₃ H Cl Cl t-Bu Cl H Br Br t-Bu Cl Br Br Br Me CH₃ H Cl Br Me Cl H CF₃ Cl Me Cl I CF₃ Cl Et CH₃ H Cl Br Et Cl H CF₃ Cl Et Cl I CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl H CF₃ Cl i-Pr Cl I CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl H CF₃ Cl t-Bu Cl I CF₃ Cl Me CH₃ H Br Cl Me Cl H CF₃ Br Me Cl I CF₃ Br Et CH₃ H Br Cl Et Cl H CF₃ Br Et Cl I CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl H CF₃ Br i-Pr Cl I CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl H CF₃ Br t-Bu Cl I CF₃ Br Me CH₃ H Br Br Me Cl H Cl Cl Me Cl I Cl Cl Et CH₃ H Br Br Et Cl H Cl Cl Et Cl I Cl Cl i-Pr CH₃ H Br Br i-Pr Cl H Cl Cl i-Pr Cl I Cl Cl t-Bu CH₃ H Br Br i-Pr Cl H Cl Cl t-Bu Cl I Cl Cl Me CH₃ F CF₃ Cl Me CH₃ Cl CF₃ Cl Me Cl I Cl Br Et CH₃ F CF₃ Cl Et CH₃ Cl CF₃ Cl Et Cl I Cl Br i-Pr CH₃ F CF₃ Cl i-Pr CH₃ Cl CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ F CF₃ Cl t-Bu CH₃ Cl CF₃ Cl t-Bu Cl I Cl Br Me CH₃ F CF₃ Br Me CH₃ Cl CF₃ Br Me Cl I Br Cl Et CH₃ F CF₃ Br Et CH₃ Cl CF₃ Br Et Cl I Br Cl i-Pr CH₃ F CF₃ Br i-Pr CH₃ Cl CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ F CF₃ Br t-Bu CH₃ Cl CF₃ Br t-Bu Cl I Br Cl Me CH₃ F Cl Cl Me CH₃ Cl Cl Cl Me Cl I Br Br Et CH₃ F Cl Cl Et CH₃ Cl Cl Cl Et Cl I Br Br i-Pr CH₃ F Cl Cl i-Pr CH₃ Cl Cl Cl i-Pr Cl I Br Br t-Bu CH₃ F Cl Cl t-Bu CH₃ Cl Cl Cl t-Bu Cl I Br Br Me CH₃ F Cl Br Me CH₃ Cl Cl Br Me Cl CF₃ CF₃ Cl Et CH₃ F Cl Br Et CH₃ Cl Cl Br Et Cl CF₃ CF₃ Cl i-Pr CH₃ F Cl Br i-Pr CH₃ Cl Cl Br i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ F Cl Br t-Bu CH₃ Cl Cl Br t-Bu Cl CF₃ CF₃ Cl Me CH₃ F Br Cl Me CH₃ Cl Br Cl Me Cl CF₃ CF₃ Br Et CH₃ F Br Cl Et CH₃ Cl Br Cl Et Cl CF₃ CF₃ Br i-Pr CH₃ F Br Cl i-Pr CH₃ Cl Br Cl i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ F Br Cl t-Bu CH₃ Cl Br Cl t-Bu Cl CF₃ CF₃ Br Me CH₃ F Br Br Me CH₃ Cl Br Br Me Cl CF₃ Cl Cl Et CH₃ F Br Br Et CH₃ Cl Br Br Et Cl CF₃ Cl Cl i-Pr CH₃ F Br Br i-Pr CH₃ Cl Br Br i-Pr Cl CF₃ Cl Cl t-Bu CH₃ F Br Br t-Bu CH₃ Cl Br Br t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Cl F CF₃ Cl Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Cl F CF₃ Cl Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Cl F CF₃ Br Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Cl F CF₃ Br Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Cl F Cl Cl Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Cl F Cl Cl Et Cl CF₃ Br Br t-Pr CH₃ Br Cl Cl i-Pr Cl F Cl Cl i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Cl F Cl Cl t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Cl F Cl Br n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Cl F Cl Br n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Cl F Cl Br s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Cl F Cl Br i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Cl F Br Cl Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Cl F Br Cl Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Cl F Br Cl i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Cl F Br Cl t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Cl F Br Br Me Br F CF₃ Br Et CH₃ Br Br Br Et Cl F Br Br Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Cl F Br Br i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Cl F Br Br t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Cl Cl CF₃ Cl Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Cl Cl CF₃ Cl Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Cl Cl CF₃ Br Me Br F Cl Br Et CH₃ I CF₃ Br Et Cl Cl CF₃ Br Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Cl Cl Cl Cl Me Br F Br Cl Et CH₃ I Cl Cl Et Cl Cl Cl Cl Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Cl Cl Cl Cl i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Cl Cl Cl Cl t-Bu Br F Br Cl Me CH₃ I Cl Br Me Cl Cl Cl Br Me Br F Br Br Et CH₃ I Cl Br Et Cl Cl Cl Br Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Cl Cl Cl Br i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Cl Cl Cl Br t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ CF₃ Cl Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ CF₃ Cl Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ CF₃ Cl i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ CF₃ Cl t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br CF₃ CF₃ Br Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br CF₃ CF₃ Br Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br CF₃ CF₃ Br i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br CF₃ CF₃ Br t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br CF₃ Cl Cl Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br CF₃ Cl Cl Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br CF₃ Cl Cl i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br CF₃ Cl Cl t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br CF₃ Cl Br Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br CF₃ Cl Br Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br CF₃ Cl Br i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br CF₃ Cl Br t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br CF₃ Br Cl Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br CF₃ Br Cl Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br CF₃ Br Cl i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br CF₃ Br Cl t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me Br CF₃ Br Br Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et Br CF₃ Br Br Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr Br CF₃ Br Br i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu Br CF₃ Br Br t-Bu Br Cl Br Br Me CH₃ CF₃ Br Cl Me Br I CF₃ Cl Me Br Br CF₃ Cl Et CH₃ CF₃ Br Cl Et Br I CF₃ Cl Et Br Br CF₃ Cl i-Pr CH₃ CF₃ Br Cl i-Pr Br I CF₃ Cl i-Pr Br Br CF₃ Cl t-Bu CH₃ CF₃ Br Cl t-Bu Br I CF₃ Cl t-Bu Br Br CF₃ Cl Me CH₃ CF₃ Br Br Me Br I CF₃ Br Me Br Br CF₃ Br Et CH₃ CF₃ Br Br Et Br I CF₃ Br Et Br Br CF₃ Br i-Pr CH₃ CF₃ Br Br i-Pr Br I CF₃ Br i-Pr Br Br CF₃ Br t-Bu CH₃ CF₃ Br Br t-Bu Br I CF₃ Br t-Bu Br Br CF₃ Br n-Pr CH₃ Cl Cl Cl Me Br I Cl Cl Me Br Br Cl Cl n-Bu CH₃ Cl Cl Cl Et Br I Cl Cl Et Br Br Cl Cl s-Bu CH₃ Cl Cl Cl i-Pr Br I Cl Cl i-Pr Br Br Cl Cl i-Bu CH₃ Cl Cl Cl t-Bu Br I Cl Cl t-Bu Br Br Cl Cl Me Cl Cl Br Cl Me Br I Cl Br Me Br Br Cl Br Et Cl Cl Br Cl Et Br I Cl Br Et Br Br Cl Br i-Pr Cl Cl Br Cl i-Pr Br I Cl Br i-Pr Br Br Cl Br t-Bu Cl Cl Br Cl t-Bu Br I Cl Br t-Bu Br Br Cl Br Me Cl Cl Br Br Me Br I Br Cl Me Br Br Br Cl Et Cl Cl Br Br Et Br I Br Cl Et Br Br Br Cl i-Pr Cl Cl Br Br i-Pr Br I Br Cl i-Pr Br Br Br Cl t-Bu Cl Cl Br Br t-Bu Br I Br Cl t-Bu Br Br Br Cl Me Cl Br CF₃ Cl Me Br I Br Br Me Br Br Br Br Et Cl Br CF₃ Cl Et Br I Br Br Et Br Br Br Br i-Pr Cl Br CF₃ Cl i-Pr Br I Br Br i-Pr Br Br Br Br t-Bu Cl Br CF₃ Cl t-Bu Br I Br Br t-Bu Br Br Br Br Me Cl Br CF₃ Br Me Cl Br Cl Cl t-Bu Cl Br CF₃ Br Et Cl Br CF₃ Br Et Cl Br Cl Cl t-Bu Cl Br Cl Cl i-Pr Cl Br CF₃ Br i-Pr Cl Br Cl Cl

TABLE 8

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl H Cl Br Me Cl Br Cl Br Et CH₃ H CF₃ Cl Et Cl H Cl Br Et Cl Br Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl H Cl Br i-Pr Cl Br Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl H Cl Br t-Bu Cl Br Cl Br Me CH₃ H CF₃ Br Me Cl H Br Cl Me Cl Br Br Cl Et CH₃ H CF₃ Br Et Cl H Br Cl Et Cl Br Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl H Br Cl i-Pr Cl Br Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl H Br Cl t-Bu Cl Br Br Cl Me CH₃ H Cl Cl Me Cl H Br Br Me Cl Br Br Br Et CH₃ H Cl Cl Et Cl H Br Br Et Cl Br Br Br i-Pr CH₃ H Cl Cl i-Pr Cl H Br Br i-Pr Cl Br Br Br t-Bu CH₃ H Cl Cl t-Bu Cl H Br Br t-Bu Cl Br Br Br Me CH₃ H Cl Br Me Cl H CF₃ Cl Me Cl I CF₃ Cl Et CH₃ H Cl Br Et Cl H CF₃ Cl Et Cl I CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl H CF₃ Cl i-Pr Cl I CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl H CF₃ Cl t-Bu Cl I CF₃ Cl Me CH₃ H Br Cl Me Cl H CF₃ Br Me Cl I CF₃ Br Et CH₃ H Br Cl Et Cl H CF₃ Br Et Cl I CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl H CF₃ Br i-Pr Cl I CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl H CF₃ Br t-Bu Cl I CF₃ Br Me CH₃ H Br Br Me Cl H Cl Cl Me Cl I Cl Cl Et CH₃ H Br Br Et Cl H Cl Cl Et Cl I Cl Cl i-Pr CH₃ H Br Br i-Pr Cl H Cl Cl i-Pr Cl I Cl Cl t-Bu CH₃ H Br Br i-Pr Cl H Cl Cl t-Bu Cl I Cl Cl Me CH₃ F CF₃ Cl Me CH₃ Cl CF₃ Cl Me Cl I Cl Br Et CH₃ F CF₃ Cl Et CH₃ Cl CF₃ Cl Et Cl I Cl Br i-Pr CH₃ F CF₃ Cl i-Pr CH₃ Cl CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ F CF₃ Cl t-Bu CH₃ Cl CF₃ Cl t-Bu Cl I Cl Br Me CH₃ F CF₃ Br Me CH₃ Cl CF₃ Br Me Cl I Br Cl Et CH₃ F CF₃ Br Et CH₃ Cl CF₃ Br Et Cl I Br Cl i-Pr CH₃ F CF₃ Br i-Pr CH₃ Cl CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ F CF₃ Br t-Bu CH₃ Cl CF₃ Br t-Bu Cl I Br Cl Me CH₃ F Cl Cl Me CH₃ Cl Cl Cl Me Cl I Br Br Et CH₃ F Cl Cl Et CH₃ Cl Cl Cl Et Cl I Br Br i-Pr CH₃ F Cl Cl i-Pr CH₃ Cl Cl Cl i-Pr Cl I Br Br t-Bu CH₃ F Cl Cl t-Bu CH₃ Cl Cl Cl t-Bu Cl I Br Br Me CH₃ F Cl Br Me CH₃ Cl Cl Br Me Cl CF₃ CF₃ Cl Et CH₃ F Cl Br Et CH₃ Cl Cl Br Et Cl CF₃ CF₃ Cl i-Pr CH₃ F Cl Br i-Pr CH₃ Cl Cl Br i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ F Cl Br t-Bu CH₃ Cl Cl Br t-Bu Cl CF₃ CF₃ Cl Me CH₃ F Br Cl Me CH₃ Cl Br Cl Me Cl CF₃ CF₃ Br Et CH₃ F Br Cl Et CH₃ Cl Br Cl Et Cl CF₃ CF₃ Br i-Pr CH₃ F Br Cl i-Pr CH₃ Cl Br Cl i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ F Br Cl t-Bu CH₃ Cl Br Cl t-Bu Cl CF₃ CF₃ Br Me CH₃ F Br Br Me CH₃ Cl Br Br Me Cl CF₃ Cl Cl Et CH₃ F Br Br Et CH₃ Cl Br Br Et Cl CF₃ Cl Cl i-Pr CH₃ F Br Br i-Pr CH₃ Cl Br Br i-Pr Cl CF₃ Cl Cl t-Bu CH₃ F Br Br t-Bu CH₃ Cl Br Br t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Cl F CF₃ Cl Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Cl F CF₃ Cl Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Cl F CF₃ Br Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Cl F CF₃ Br Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Cl F Cl Cl Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Cl F Cl Cl Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Cl F Cl Cl i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Cl F Cl Cl t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Cl F Cl Br n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Cl F Cl Br n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Cl F Cl Br s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Cl F Cl Br i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Cl F Br Cl Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Cl F Br Cl Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Cl F Br Cl i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Cl F Br Cl t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Cl F Br Br Me Br F CF₃ Br Et CH₃ Br Br Br Et Cl F Br Br Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Cl F Br Br i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Cl F Br Br t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Cl Cl CF₃ Cl Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Cl Cl CF₃ Cl Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Cl Cl CF₃ Br Me Br F Cl Br Et CH₃ I CF₃ Br Et Cl Cl CF₃ Br Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Cl Cl Cl Cl Me Br F Br Cl Et CH₃ I Cl Cl Et Cl Cl Cl Cl Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Cl Cl Cl Cl i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Cl Cl Cl Cl t-Bu Br F Br Cl Me CH₃ I Cl Br Me Cl Cl Cl Br Me Br F Br Br Et CH₃ I Cl Br Et Cl Cl Cl Br Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Cl Cl Cl Br i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Cl Cl Cl Br t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ CF₃ Cl Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ CF₃ Cl Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ CF₃ Cl i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ CF₃ Cl t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br CF₃ CF₃ Br Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br CF₃ CF₃ Br Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br CF₃ CF₃ Br i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br CF₃ CF₃ Br t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br CF₃ Cl Cl Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br CF₃ Cl Cl Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br CF₃ Cl Cl i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br CF₃ Cl Cl t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br CF₃ Cl Br Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br CF₃ Cl Br Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br CF₃ Cl Br i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br CF₃ Cl Br t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br CF₃ Br Cl Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br CF₃ Br Cl Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br CF₃ Br Cl i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br CF₃ Br Cl t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me Br CF₃ Br Br Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et Br CF₃ Br Br Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr Br CF₃ Br Br i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu Br CF₃ Br Br t-Bu Br Cl Br Br Me CH₃ CF₃ Br Cl Me Br I CF₃ Cl Me Br Br CF₃ Cl Et CH₃ CF₃ Br Cl Et Br I CF₃ Cl Et Br Br CF₃ Cl i-Pr CH₃ CF₃ Br Cl i-Pr Br I CF₃ Cl i-Pr Br Br CF₃ Cl t-Bu CH₃ CF₃ Br Cl t-Bu Br I CF₃ Cl t-Bu Br Br CF₃ Cl Me CH₃ CF₃ Br Br Me Br I CF₃ Br Me Br Br CF₃ Br Et CH₃ CF₃ Br Br Et Br I CF₃ Br Et Br Br CF₃ Br i-Pr CH₃ CF₃ Br Br i-Pr Br I CF₃ Br i-Pr Br Br CF₃ Br t-Bu CH₃ CF₃ Br Br t-Bu Br I CF₃ Br t-Bu Br Br CF₃ Br n-Pr CH₃ Cl Cl Cl Me Br I Cl Cl Me Br Br Cl Cl n-Bu CH₃ Cl Cl Cl Et Br I Cl Cl Et Br Br Cl Cl s-Bu CH₃ Cl Cl Cl i-Pr Br I Cl Cl i-Pr Br Br Cl Cl i-Bu CH₃ Cl Cl Cl t-Bu Br I Cl Cl t-Bu Br Br Cl Cl Me Cl Cl Br Cl Me Br I Cl Br Me Br Br Cl Br Et Cl Cl Br Cl Et Br I Cl Br Et Br Br Cl Br i-Pr Cl Cl Br Cl i-Pr Br I Cl Br i-Pr Br Br Cl Br t-Bu Cl Cl Br Cl t-Bu Br I Cl Br t-Bu Br Br Cl Br Me Cl Cl Br Br Me Br I Br Cl Me Br Br Br Cl Et Cl Cl Br Br Et Br I Br Cl Et Br Br Br Cl i-Pr Cl Cl Br Br i-Pr Br I Br Cl i-Pr Br Br Br Cl t-Bu Cl Cl Br Br t-Bu Br I Br Cl t-Bu Br Br Br Cl Me Cl Br CF₃ Cl Me Br I Br Br Me Br Br Br Br Et Cl Br CF₃ Cl Et Br I Br Br Et Br Br Br Br i-Pr Cl Br CF₃ Cl i-Pr Br I Br Br i-Pr Br Br Br Br t-Bu Cl Br CF₃ Cl t-Bu Br I Br Br t-Bu Br Br Br Br Me Cl Br CF₃ Br Me Cl Br Cl Cl t-Bu Cl Br CF₃ Br Et Cl Br CF₃ Br Et Cl Br Cl Cl t-Bu Cl Br Cl Cl i-Pr Cl Br CF₃ Br i-Pr Cl Br Cl Cl

TABLE 9

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ H CH₃ H CF₃ F H Cl H CF₃ F H Br H CF₃ F Me CH₃ H CF₃ F Me Cl H CF₃ F Me Br H CF₃ F Et CH₃ H CF₃ F Et Cl H CF₃ F Et Br H CF₃ F i-Pr CH₃ H CF₃ F i-Pr Cl H CF₃ F i-Pr Br H CF₃ F t-Bu CH₃ H CF₃ F t-Bu Cl H CF₃ F t-Bu Br H CF₃ F H CH₃ H CF₃ Cl H Cl H CF₃ Cl H Br H CF₃ Cl Me CH₃ H CF₃ Cl Me Cl H CF₃ Cl Me Br H CF₃ Cl Et CH₃ H CF₃ Cl Et Cl H CF₃ Cl Et Br H CF₃ Cl i-Pr CH₃ H CF₃ Cl i-Pr Cl H CF₃ Cl i-Pr Br H CF₃ Cl t-Bu CH₃ H CF₃ Cl t-Bu Cl H CF₃ Cl t-Bu Br H CF₃ Cl H CH₃ H CF₃ Br H Cl H CF₃ Br H Br H CF₃ Br Me CH₃ H CF₃ Br Me Cl H CF₃ Br Me Br H CF₃ Br Et CH₃ H CF₃ Br Et Cl H CF₃ Br Et Br H CF₃ Br i-Pr CH₃ H CF₃ Br i-Pr Cl H CF₃ Br i-Pr Br H CF₃ Br t-Bu CH₃ H CF₃ Br t-Bu Cl H CF₃ Br t-Bu Br H CF₃ Br H CH₃ H Cl F H Cl H Cl F H Br H Cl F Me CH₃ H Cl F Me Cl H Cl F Me Br H Cl F Et CH₃ H Cl F Et Cl H Cl F Et Br H Cl F i-Pr CH₃ H Cl F i-Pr Cl H Cl F i-Pr Br H Cl F t-Bu CH₃ H Cl F t-Bu Cl H Cl F t-Bu Br H Cl F H CH₃ H Cl Cl H Cl H Cl Cl H Br H Cl Cl Me CH₃ H Cl Cl Me Cl H Cl Cl Me Br H Cl Cl Et CH₃ H Cl Cl Et Cl H Cl Cl Et Br H Cl Cl i-Pr CH₃ H Cl Cl i-Pr Cl H Cl Cl i-Pr Br H Cl Cl t-Bu CH₃ H Cl Cl t-Bu Cl H Cl Cl t-Bu Br H Cl Cl H CH₃ H Cl Br H Cl H Cl Br H Br H Cl Br Me CH₃ H Cl Br Me Cl H Cl Br Me Br H Cl Br Et CH₃ H Cl Br Et Cl H Cl Br Et Br H Cl Br i-Pr CH₃ H Cl Br i-Pr Cl H Cl Br i-Pr Br H Cl Br t-Bu CH₃ H Cl Br t-Bu Cl H Cl Br t-Bu Br H Cl Br H CH₃ H Br F H Cl H Br F H Br H Br F Me CH₃ H Br F Me Cl H Br F Me Br H Br F Et CH₃ H Br F Et Cl H Br F Et Br H Br F i-Pr CH₃ H Br F i-Pr Cl H Br F i-Pr Br H Br F t-Bu CH₃ H Br F t-Bu Cl H Br F t-Bu Br H Br F H CH₃ H Br Cl H Cl H Br Cl H Br H Br Cl Me CH₃ H Br Cl Me Cl H Br Cl Me Br H Br Cl Et CH₃ H Br Cl Et Cl H Br Cl Et Br H Br Cl i-Pr CH₃ H Br Cl i-Pr Cl H Br Cl i-Pr Br H Br Cl t-Bu CH₃ H Br Cl t-Bu Cl H Br Cl t-Bu Br H Br Cl H CH₃ H Br Br H Cl H Br Br H Br H Br Br Me CH₃ H Br Br Me Cl H Br Br Me Br H Br Br Et CH₃ H Br Br Et Cl H Br Br Et Br H Br Br i-Pr CH₃ H Br Br i-Pr Cl H Br Br i-Pr Br H Br Br t-Bu CH₃ H Br Br t-Bu Cl H Br Br t-Bu Br H Br Br H CH₃ F CF₃ F H Cl F CF₃ F H Br F CF₃ F Me CH₃ F CF₃ F Me Cl F CF₃ F Me Br F CF₃ F Et CH₃ F CF₃ F Et Cl F CF₃ F Et Br F CF₃ F i-Pr CH₃ F CF₃ F i-Pr Cl F CF₃ F i-Pr Br F CF₃ F t-Bu CH₃ F CF₃ F t-Bu Cl F CF₃ F t-Bu Br F CF₃ F H CH₃ F CF₃ Cl H Cl F CF₃ Cl H Br F CF₃ Cl Me CH₃ F CF₃ Cl Me Cl F CF₃ Cl Me Br F CF₃ Cl Et CH₃ F CF₃ Cl Et Cl F CF₃ Cl Et Br F CF₃ Cl i-Pr CH₃ F CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Br F CF₃ Cl t-Bu CH₃ F CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Br F CF₃ Cl H CH₃ F CF₃ Br H Cl F CF₃ Br H Br F CF₃ Br Me CH₃ F CF₃ Br Me Cl F CF₃ Br Me Br F CF₃ Br Et CH₃ F CF₃ Br Et Cl F CF₃ Br Et Br F CF₃ Br i-Pr CH₃ F CF₃ Br i-Pr Cl F CF₃ Br i-Pr Br F CF₃ Br t-Bu CH₃ F CF₃ Br t-Bu Cl F CF₃ Br t-Bu Br F CF₃ Br H CH₃ F Cl F H Cl F Cl F H Br F Cl F Me CH₃ F Cl F Me Cl F Cl F Me Br F Cl F Et CH₃ F Cl F Et Cl F Cl F Et Br F Cl F i-Pr CH₃ F Cl F i-Pr Cl F Cl F i-Pr Br F Cl F t-Bu CH₃ F Cl F t-Bu Cl F Cl F t-Bu Br F Cl F H CH₃ F Cl Cl H Cl F Cl Cl H Br F Cl Cl Me CH₃ F Cl Cl Me Cl F Cl Cl Me Br F Cl Cl Et CH₃ F Cl Cl Et Cl F Cl Cl Et Br F Cl Cl i-Pr CH₃ F Cl Cl i-Pr Cl F Cl Cl i-Pr Br F Cl Cl t-Bu CH₃ F Cl Cl t-Bu Cl F Cl Cl t-Bu Br F Cl Cl H CH₃ F Cl Br H Cl F Cl Br H Br F Cl Br Me CH₃ F Cl Br Me Cl F Cl Br Me Br F Cl Br Et CH₃ F Cl Br Et Cl F Cl Br Et Br F Cl Br i-Pr CH₃ F Cl Br i-Pr Cl F Cl Br i-Pr Br F Cl Br t-Bu CH₃ F Cl Br t-Bu Cl F Cl Br t-Bu Br F Cl Br H CH₃ F Br F H Cl F Br F H Br F Br F Me CH₃ F Br F Me Cl F Br F Me Br F Br F Et CH₃ F Br F Et Cl F Br F Et Br F Br F i-Pr CH₃ F Br F i-Pr Cl F Br F i-Pr Br F Br F t-Bu CH₃ F Br F t-Bu Cl F Br F t-Bu Br F Br F H CH₃ F Br Cl H Cl F Br Cl H Br F Br Cl Me CH₃ F Br Cl Me Cl F Br Cl Me Br F Br Cl Et CH₃ F Br Cl Et Cl F Br Cl Et Br F Br Cl i-Pr CH₃ F Br Cl i-Pr Cl F Br Cl i-Pr Br F Br Cl t-Bu CH₃ F Br Cl t-Bu Cl F Br Cl t-Bu Br F Br Cl H CH₃ F Br Br H Cl F Br Br H Br F Br Br Me CH₃ F Br Br Me Cl F Br Br Me Br F Br Br Et CH₃ F Br Br Et Cl F Br Br Et Br F Br Br i-Pr CH₃ F Br Br i-Pr Cl F Br Br i-Pr Br F Br Br t-Bu CH₃ F Br Br t-Bu Cl F Br Br t-Bu Br F Br Br H CH₃ Cl CF₃ F H Cl Cl CF₃ F H Br Cl CF₃ F Me CH₃ Cl CF₃ F Me Cl Cl CF₃ F Me Br Cl CF₃ F Et CH₃ Cl CF₃ F Et Cl Cl CF₃ F Et Br Cl CF₃ F i-Pr CH₃ Cl CF₃ F i-Pr Cl Cl CF₃ F i-Pr Br Cl CF₃ F t-Bu CH₃ Cl CF₃ F t-Bu Cl Cl CF₃ F t-Bu Br Cl CF₃ F H CH₃ Cl CF₃ Cl H Cl Cl CF₃ Cl H Br Cl CF₃ Cl Me CH₃ Cl CF₃ Cl Me Cl Cl CF₃ Cl Me Br Cl CF₃ Cl Et CH₃ Cl CF₃ Cl Et Cl Cl CF₃ Cl Et Br Cl CF₃ Cl i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Br Cl CF₃ Cl t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Br Cl CF₃ Cl H CH₃ Cl CF₃ Br H Cl Cl CF₃ Br H Br Cl CF₃ Br Me CH₃ Cl CF₃ Br Me Cl Cl CF₃ Br Me Br Cl CF₃ Br Et CH₃ Cl CF₃ Br Et Cl Cl CF₃ Br Et Br Cl CF₃ Br i-Pr CH₃ Cl CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Br Cl CF₃ Br t-Bu CH₃ Cl CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Br Cl CF₃ Br H CH₃ Cl Cl F H Cl Cl Cl F H Br Cl Cl F Me CH₃ Cl Cl F Me Cl Cl Cl F Me Br Cl Cl F Et CH₃ Cl Cl F Et Cl Cl Cl F Et Br Cl Cl F i-Pr CH₃ Cl Cl F i-Pr Cl Cl Cl F i-Pr Br Cl Cl F t-Bu CH₃ Cl Cl F t-Bu Cl Cl Cl F t-Bu Br Cl Cl F H CH₃ Cl Cl Cl H Cl Cl Cl Cl H Br Cl Cl Cl Me CH₃ Cl Cl Cl Me Cl Cl Cl Cl Me Br Cl Cl Cl Et CH₃ Cl Cl Cl Et Cl Cl Cl Cl Et Br Cl Cl Cl i-Pr CH₃ Cl Cl Cl i-Pr Cl Cl Cl Cl i-Pr Br Cl Cl Cl t-Bu CH₃ Cl Cl Cl t-Bu Cl Cl Cl Cl t-Bu Br Cl Cl Cl H CH₃ Cl Cl Br H Cl Cl Cl Br H Br Cl Cl Br Me CH₃ Cl Cl Br Me Cl Cl Cl Br Me Br Cl Cl Br Et CH₃ Cl Cl Br Et Cl Cl Cl Br Et Br Cl Cl Br i-Pr CH₃ Cl Cl Br i-Pr Cl Cl Cl Br i-Pr Br Cl Cl Br t-Bu CH₃ Cl Cl Br t-Bu Cl Cl Cl Br t-Bu Br Cl Cl Br H CH₃ Cl Br F H Cl Cl Br F H Br Cl Br F Me CH₃ Cl Br F Me Cl Cl Br F Me Br Cl Br F Et CH₃ Cl Br F Et Cl Cl Br F Et Br Cl Br F i-Pr CH₃ Cl Br F i-Pr Cl Cl Br F i-Pr Br Cl Br F t-Bu CH₃ Cl Br F t-Bu Cl Cl Br F t-Bu Br Cl Br F H CH₃ Cl Br Cl H Cl Cl Br Cl H Br Cl Br Cl Me CH₃ Cl Br Cl Me Cl Cl Br Cl Me Br Cl Br Cl Et CH₃ Cl Br Cl Et Cl Cl Br Cl Et Br Cl Br Cl i-Pr CH₃ Cl Br Cl i-Pr Cl Cl Br Cl i-Pr Br Cl Br Cl t-Bu CH₃ Cl Br Cl t-Bu Cl Cl Br Cl t-Bu Br Cl Br Cl H CH₃ Cl Br Br H Cl Cl Br Br H Br Cl Br Br Me CH₃ Cl Br Br Me Cl Cl Br Br Me Br Cl Br Br Et CH₃ Cl Br Br Et Cl Cl Br Br Et Br Cl Br Br i-Pr CH₃ Cl Br Br i-Pr Cl Cl Br Br i-Pr Br Cl Br Br t-Bu CH₃ Cl Br Br t-Bu Cl Cl Br Br t-Bu Br Cl Br Br H CH₃ Br CF₃ F H Cl Br CF₃ F H Br Br CF₃ F Me CH₃ Br CF₃ F Me Cl Br CF₃ F Me Br Br CF₃ F Et CH₃ Br CF₃ F Et Cl Br CF₃ F Et Br Br CF₃ F i-Pr CH₃ Br CF₃ F i-Pr Cl Br CF₃ F i-Pr Br Br CF₃ F t-Bu CH₃ Br CF₃ F t-Bu Cl Br CF₃ F t-Bu Br Br CF₃ F H CH₃ Br CF₃ Cl H Cl Br CF₃ Cl H Br Br CF₃ Cl Me CH₃ Br CF₃ Cl Me Cl Br CF₃ Cl Me Br Br CF₃ Cl Et CH₃ Br CF₃ Cl Et Cl Br CF₃ Cl Et Br Br CF₃ Cl i-Pr CH₃ Br CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Br Br CF₃ Cl t-Bu CH₃ Br CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Br Br CF₃ Cl H CH₃ Br CF₃ Br H Cl Br CF₃ Br H Br Br CF₃ Br Me CH₃ Br CF₃ Br Me Cl Br CF₃ Br Me Br Br CF₃ Br Et CH₃ Br CF₃ Br Et Cl Br CF₃ Br Et Br Br CF₃ Br i-Pr CH₃ Br CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Br Br CF₃ Br t-Bu CH₃ Br CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Br Br CF₃ Br H CH₃ Br Cl F H Cl Br Cl F H Br Br Cl F Me CH₃ Br Cl F Me Cl Br Cl F Me Br Br Cl F Et CH₃ Br Cl F Et Cl Br Cl F Et Br Br Cl F i-Pr CH₃ Br Cl F i-Pr Cl Br Cl F i-Pr Br Br Cl F t-Bu CH₃ Br Cl F t-Bu Cl Br Cl F t-Bu Br Br Cl F H CH₃ Br Cl Cl H Cl Br Cl Cl H Br Br Cl Cl Me CH₃ Br Cl Cl Me Cl Br Cl Cl Me Br Br Cl Cl Et CH₃ Br Cl Cl Et Cl Br Cl Cl Et Br Br Cl Cl i-Pr CH₃ Br Cl Cl i-Pr Cl Br Cl Cl i-Pr Br Br Cl Cl t-Bu CH₃ Br Cl Cl t-Bu Cl Br Cl Cl t-Bu Br Br Cl Cl H CH₃ Br Cl Br H Cl Br Cl Br H Br Br Cl Br Me CH₃ Br Cl Br Me Cl Br Cl Br Me Br Br Cl Br Et CH₃ Br Cl Br Et Cl Br Cl Br Et Br Br Cl Br i-Pr CH₃ Br Cl Br i-Pr Cl Br Cl Br i-Pr Br Br Cl Br t-Bu CH₃ Br Cl Br t-Bu Cl Br Cl Br t-Bu Br Br Cl Br H CH₃ Br Br F H Cl Br Br F H Br Br Br F Me CH₃ Br Br F Me Cl Br Br F Me Br Br Br F Et CH₃ Br Br F Et Cl Br Br F Et Br Br Br F i-Pr CH₃ Br Br F i-Pr Cl Br Br F i-Pr Br Br Br F t-Bu CH₃ Br Br F t-Bu Cl Br Br F t-Bu Br Br Br F H CH₃ Br Br Cl H Cl Br Br Cl H Br Br Br Cl Me CH₃ Br Br Cl Me Cl Br Br Cl Me Br Br Br Cl Et CH₃ Br Br Cl Et Cl Br Br Cl Et Br Br Br Cl i-Pr CH₃ Br Br Cl i-Pr Cl Br Br Cl i-Pr Br Br Br Cl t-Bu CH₃ Br Br Cl t-Bu Cl Br Br Cl t-Bu Br Br Br Cl H CH₃ Br Br Br H Cl Br Br Br H Br Br Br Br Me CH₃ Br Br Br Me Cl Br Br Br Me Br Br Br Br Et CH₃ Br Br Br Et Cl Br Br Br Et Br Br Br Br i-Pr CH₃ Br Br Br i-Pr Cl Br Br Br i-Pr Br Br Br Br t-Bu CH₃ Br Br Br t-Bu Cl Br Br Br t-Bu Br Br Br Br H CH₃ I CF₃ F H Cl I CF₃ F H Br I CF₃ F Me CH₃ I CF₃ F Me Cl I CF₃ F Me Br I CF₃ F Et CH₃ I CF₃ F Et Cl I CF₃ F Et Br I CF₃ F i-Pr CH₃ I CF₃ F i-Pr Cl I CF₃ F i-Pr Br I CF₃ F t-Bu CH₃ I CF₃ F t-Bu Cl I CF₃ F t-Bu Br I CF₃ F H CH₃ I CF₃ Cl H Cl I CF₃ Cl H Br I CF₃ Cl Me CH₃ I CF₃ Cl Me Cl I CF₃ Cl Me Br I CF₃ Cl Et CH₃ I CF₃ Cl Et Cl I CF₃ Cl Et Br I CF₃ Cl i-Pr CH₃ I CF₃ Cl i-Pr Cl I CF₃ Cl i-Pr Br I CF₃ Cl t-Bu CH₃ I CF₃ Cl t-Bu Cl I CF₃ Cl t-Bu Br I CF₃ Cl H CH₃ I CF₃ Br H Cl I CF₃ Br H Br I CF₃ Br Me CH₃ I CF₃ Br Me Cl I CF₃ Br Me Br I CF₃ Br Et CH₃ I CF₃ Br Et Cl I CF₃ Br Et Br I CF₃ Br i-Pr CH₃ I CF₃ Br i-Pr Cl I CF₃ Br i-Pr Br I CF₃ Br t-Bu CH₃ I CF₃ Br t-Bu Cl I CF₃ Br t-Bu Br I CF₃ Br H CH₃ I Cl F H Cl I Cl F H Br I Cl F Me CH₃ I Cl F Me Cl I Cl F Me Br I Cl F Et CH₃ I Cl F Et Cl I Cl F Et Br I Cl F i-Pr CH₃ I Cl P i-Pr Cl I Cl F i-Pr Br I Cl F t-Bu CH₃ I Cl F t-Bu Cl I Cl F t-Bu Br I Cl F H CH₃ I Cl Cl H Cl I Cl Cl H Br I Cl Cl Me CH₃ I Cl Cl Me Cl I Cl Cl Me Br I Cl Cl Et CH₃ I Cl Cl Et Cl I Cl Cl Et Br I Cl Cl i-Pr CH₃ I Cl Cl i-Pr Cl I Cl Cl i-Pr Br I Cl Cl t-Bu CH₃ I Cl Cl t-Bu Cl I Cl Cl t-Bu Br I Cl Cl H CH₃ I Cl Br H Cl I Cl Br H Br I Cl Br Me CH₃ I Cl Br Me Cl I Cl Br Me Br I Cl Br Et CH₃ I Cl Br Et Cl I Cl Br Et Br I Cl Br i-Pr CH₃ I Cl Br i-Pr Cl I Cl Br i-Pr Br I Cl Br t-Bu CH₃ I Cl Br t-Bu Cl I Cl Br t-Bu Br I Cl Br H CH₃ I Br F H Cl I Br F H Br I Br F Me CH₃ I Br F Me Cl I Br F Me Br I Br F Et CH₃ I Br F Et Cl I Br F Et Br I Br F i-Pr CH₃ I Br F i-Pr Cl I Br F i-Pr Br I Br F H CH₃ I Br Cl H Cl I Br Cl H Br I Br Cl Me CH₃ I Br Cl Me Cl I Br Cl Me Br I Br Cl Et CH₃ I Br Cl Et Cl I Br Cl Et Br I Br Cl i-Pr CH₃ I Br Cl i-Pr Cl I Br Cl i-Pr Br I Br Cl t-Bu CH₃ I Br Cl t-Bu Cl I Br Cl t-Bu Br I Br Cl H CH₃ I Br Br H Cl I Br Br H Br I Br Br Me CH₃ I Br Br Me Cl I Br Br Me Br I Br Br Et CH₃ I Br Br Et Cl I Br Br Et Br I Br Br i-Pr CH₃ I Br Br i-Pr Cl I Br Br i-Pr Br I Br Br t-Bu CH₃ I Br Br t-Bu Cl I Br Br t-Bu Br I Br Br H CH₃ CF₃ CF₃ F H Cl CF₃ CF₃ F H Br CF₃ CF₃ F Me CH₃ CF₃ CF₃ F Me Cl CF₃ CF₃ F Me Br CF₃ CF₃ F Et CH₃ CF₃ CF₃ F Et Cl CF₃ CF₃ F Et Br CF₃ CF₃ F i-Pr CH₃ CF₃ CF₃ F i-Pr Cl CF₃ CF₃ F i-Pr Br CF₃ CF₃ F t-Bu CH₃ CF₃ CF₃ F t-Bu Cl CF₃ CF₃ F t-Bu Br CF₃ CF₃ F H CH₃ CF₃ CF₃ Cl H Cl CF₃ CF₃ Cl H Br CF₃ CF₃ Cl Me CH₃ CF₃ CF₃ Cl Me Cl CF₃ CF₃ Cl Me Br CF₃ CF₃ Cl Et CH₃ CF₃ CF₃ Cl Et Cl CF₃ CF₃ Cl Et Br CF₃ CF₃ Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Cl CF₃ CF₃ Cl i-Pr Br CF₃ CF₃ Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Cl CF₃ CF₃ Cl t-Bu Br CF₃ CF₃ Cl H CH₃ CF₃ CF₃ Br H Cl CF₃ CF₃ Br H Br CF₃ CF₃ Br Me CH₃ CF₃ CF₃ Br Me Cl CF₃ CF₃ Br Me Br CF₃ CF₃ Br Et CH₃ CF₃ CF₃ Br Et Cl CF₃ CF₃ Br Et Br CF₃ CF₃ Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Cl CF₃ CF₃ Br i-Pr Br CF₃ CF₃ Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Cl CF₃ CF₃ Br t-Bu Br CF₃ CF₃ Br H CH₃ CF₃ Cl F H Cl CF₃ Cl F H Br CF₃ Cl F Me CH₃ CF₃ Cl F Me Cl CF₃ Cl F Me Br CF₃ Cl F Et CH₃ CF₃ Cl F Et Cl CF₃ Cl F Et Br CF₃ Cl F i-Pr CH₃ CF₃ Cl F i-Pr Cl CF₃ Cl F i-Pr Br CF₃ Cl F t-Bu CH₃ CF₃ Cl F t-Bu Cl CF₃ Cl F t-Bu Br CF₃ Cl F H CH₃ CF₃ Cl Cl H Cl CF₃ Cl Cl H Br CF₃ Cl Cl Me CH₃ CF₃ Cl Cl Me Cl CF₃ Cl Cl Me Br CF₃ Cl Cl Et CH₃ CF₃ Cl Cl Et Cl CF₃ Cl Cl Et Br CF₃ Cl Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Cl CF₃ Cl Cl i-Pr Br CF₃ Cl Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Cl CF₃ Cl Cl t-Bu Br CF₃ Cl Cl H CH₃ CF₃ Cl Br H Cl CF₃ Cl Br H Br CF₃ Cl Br Me CH₃ CF₃ Cl Br Me Cl CF₃ Cl Br Me Br CF₃ Cl Br Et CH₃ CF₃ Cl Br Et Cl CF₃ Cl Br Et Br CF₃ Cl Br i-Pr CH₃ CF₃ Cl Br i-Pr Cl CF₃ Cl Br i-Pr Br CF₃ Cl Br t-Bu CH₃ CF₃ Cl Br t-Bu Cl CF₃ Cl Br t-Bu Br CF₃ Cl Br H CH₃ CF₃ Br F H Cl CF₃ Br F H Br CF₃ Br F Me CH₃ CF₃ Br F Me Cl CF₃ Br F Me Br CF₃ Br F Et CH₃ CF₃ Br F Et Cl CF₃ Br F Et Br CF₃ Br F i-Pr CH₃ CF₃ Br F i-Pr Cl CF₃ Br F i-Pr Br CF₃ Br F t-Bu CH₃ CF₃ Br F t-Bu Cl CF₃ Br F t-Bu Br CF₃ Br F H CH₃ CF₃ Br Cl H Cl CF₃ Br Cl H Br CF₃ Br Cl Me CH₃ CF₃ Br Cl Me Cl CF₃ Br Cl Me Br CF₃ Br Cl Et CH₃ CF₃ Br Cl Et Cl CF₃ Br Cl Et Br CF₃ Br Cl i-Pr CH₃ CF₃ Br Cl i-Pr Cl CF₃ Br Cl i-Pr Br CF₃ Br Cl t-Bu CH₃ CF₃ Br Cl t-Bu Cl CF₃ Br Cl t-Bu Br CF₃ Br Cl H CH₃ CF₃ Br Br H Cl CF₃ Br Br H Br CF₃ Br Br Me CH₃ CF₃ Br Br Me Cl CF₃ Br Br Me Br CF₃ Br Br Et CH₃ CF₃ Br Br Et Cl CF₃ Br Br Et Br CF₃ Br Br i-Pr CH₃ CF₃ Br Br i-Pr Cl CF₃ Br Br i-Pr Br CF₃ Br Br t-Bu CH₃ CF₃ Br Br t-Bu Cl CF₃ Br Br t-Bu Br CF₃ Br Br n-Pr CH₃ Cl Cl Cl n-Pr Cl Cl Cl Cl n-Bu CH₃ Cl Cl Cl n-Bu Cl Cl Cl Cl s-Bu CH₃ Cl Cl Cl s-Bu Cl Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Bu Cl Cl Cl Cl

TABLE 10

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl

TABLE 11

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl

TABLE 12

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl

TABLE 13

R^(5b) is CHF₂ R^(5b) is CH₂CF₃ R^(5b) is CF₂CHF₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 14

R^(5b) is CHF₂ R^(5b) is CH₂CF₃ R^(5b) is CF₂CHF₂ R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) R² R^(4a) R^(4b) R^(5a) i-Pr Me H Me i-Pr Me H Me i-Pr Me H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Cl H Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Me Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Cl Cl Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Me Br Me i-Pr Cl Br Me i-Pr Cl Br Me i-Pr Cl Br Me t-Bu Me H Me t-Bu Me H Me t-Bu Me H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Cl H Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Me Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Cl Cl Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Me Br Me t-Bu Cl Br Me t-Bu Cl Br Me t-Bu Cl Br Me Et Me H Me Et Me H Me Et Me H Me Et Cl H Me Et Cl H Me Et Cl H Me Et Me Cl Me Et Me Cl Me Et Me Cl Me Et Cl Cl Me Et Cl Cl Me Et Cl Cl Me Et Me Br Me Et Me Br Me Et Me Br Me Et Cl Br Me Et Cl Br Me Et Cl Br Me Me Me H Me Me Me H Me Me Me H Me Me Cl H Me Me Cl H Me Me Cl H Me Me Me Cl Me Me Me Cl Me Me Me Cl Me Me Cl Cl Me Me Cl Cl Me Me Cl Cl Me Me Me Br Me Me Me Br Me Me Me Br Me Me Cl Br Me Me Cl Br Me Me Cl Br Me

TABLE 15

R⁵ is CHF₂ R⁵ is CH₂CF₃ R⁵ is CF₂CHF₂ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ Me CH₃ H Cl Me CH₃ H Cl Me CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl Me CH₃ H Br Me CH₃ H Br Me CH₃ H Br Et CH₃ H Br Et CH₃ H Br Et CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br Me CH₃ F Cl Me CH₃ F Cl Me CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl Me CH₃ F Br Me CH₃ F Br Me CH₃ F Br Et CH₃ F Br Et CH₃ F Br Et CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br Me CH₃ Cl Cl Me HC₃ Cl Cl Me CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl Me CH₃ Cl Br Me CH₃ Cl Br Me CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br Me CH₃ Br Cl Me CH₃ Br Cl Me CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl Me CH₃ Br Br Me CH₃ Br Br Me CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br Me CH₃ I Cl Me CH₃ I Cl Me CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl Me CH₃ I Br Me CH₃ I Br Me CH₃ I Br Et CH₃ I Br Et CH₃ I Br Et CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl Me CH₃ CF₃ Br Me CH₃ CF₃ Br Me CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br n-Pr CH₃ Cl Cl Me Cl F Br Me Cl H Br n-Bu CH₃ Cl Cl Et Cl F Br Et Cl H Br s-Bu CH₃ Cl Cl i-Pr Cl F Br i-Pr Cl H Br i-Bu CH₃ Cl Cl t-Bu Cl F Br t-Bu Cl H Br Me Cl F Cl Me Cl F Cl Me Cl H Cl Et Cl F Cl Et Cl F Cl Et Cl H Cl i-Pr Cl F Cl i-Pr Cl F Cl i-Pr Cl H Cl t-Bu Cl F Cl t-Bu Cl F Cl i-Pr Cl H Cl Me Cl F Br Me Cl Cl Br Me Cl I Br Et Cl F Br Et Cl Cl Br Et Cl I Br i-Pr Cl F Br i-Pr Cl Cl Br i-Pr Cl I Br t-Bu Cl F Br t-Bu Cl Cl Br t-Bu Cl I Br Me Cl Cl Cl Me Cl Cl Cl Me Cl I Cl Et Cl Cl Cl Et Cl Cl Cl Et Cl I Cl i-Pr Cl Cl Cl i-Pr Cl Cl Cl i-Pr Cl I Cl t-Bu Cl Cl Cl t-Bu Cl Cl Cl t-Bu Cl I Cl Me Cl H Br Me Cl H Br Me Cl F Br Et Cl H Br Et Cl H Br Et Cl F Br i-Pr Cl H Br i-Pr Cl H Br i-Pr Cl F Br t-Bu Cl H Br t-Bu Cl H Br t-Bu Cl F Br Me Cl H Cl Me Cl H Cl Me Cl F Cl Et Cl H Cl Et Cl H Cl Et Cl F Cl i-Pr Cl H Cl i-Pr Cl H Cl i-Pr Cl F Cl t-Bu Cl H Cl t-Bu Cl H Cl t-Bu Cl F Cl Me Cl Br Br Me Cl Br Br Me Cl CF₃ Br Et Cl Br Br Et Cl Br Br Et Cl CF₃ Br i-Pr Cl Br Br i-Pr Cl Br Br i-Pr Cl CF₃ Br t-Bu Cl Br Br t-Bu Cl Br Br t-Bu Cl CF₃ Br Me Cl Br Cl Me Cl I Cl Me Cl CF₃ Cl Et Cl Br Cl Et Cl I Cl Et Cl CF₃ Cl i-Pr Cl Br Cl i-Pr Cl I Cl i-Pr Cl CF₃ Cl t-Bu Cl Br Cl t-Bu Cl I Cl t-Bu Cl CF₃ Cl Me Cl I Br Me Cl I Br Me Br F Cl Et Cl I Br Et Cl I Br Et Br F Cl i-Pr Cl I Br i-Pr Cl I Br i-Pr Br F Cl t-Bu Cl I Br t-Bu Cl I Br t-Bu Br F Cl Me Cl I Cl Me Cl CF₃ Cl Me Br F Br Et Cl I Cl Et Cl CF₃ Cl Et Br F Br i-Pr Cl I Cl i-Pr Cl CF₃ Cl i-Pr Br F Br t-Bu Cl I Cl t-Bu Cl CF₃ Cl t-Bu Br F Br Me Cl CF₃ Br Me Cl CF₃ Br Me Br Cl Cl Et Cl CF₃ Br Et Cl CF₃ Br Et Br Cl Cl i-Pr Cl CF₃ Br i-Pr Cl CF₃ Br i-Pr Br Cl Cl t-Bu Cl CF₃ Br t-Bu Cl CF₃ Br t-Bu Br Cl Cl Me Cl CF₃ Cl n-Pr Cl Cl Cl Me Br Cl Br Et Cl CF₃ Cl n-Bu Cl Cl Cl Et Br Cl Br i-Pr Cl CF₃ Cl s-Bu Cl Cl Cl i-Pr Br Cl Br t-Bu Cl CF₃ Cl i-Bu Cl Cl Cl t-Bu Br Cl Br Me Br F Cl Me Br F Cl Me Br Br Cl Et Br F Cl Et Br F Cl Et Br Br Cl i-Pr Br F Cl i-Pr Br F Cl i-Pr Br Br Cl t-Bu Br F Cl t-Bu Br F Cl t-Bu Br Br Cl Me Br F Br Me Br F Br Me Br Br Br Et Br F Br Et Br F Br Et Br Br Br i-Pr Br F Br i-Pr Br F Br i-Pr Br Br Br t-Bu Br F Br t-Bu Br F Br t-Bu Br Br Br Me Br Cl Cl Me Br Cl Cl Me Br I Cl Et Br Cl Cl Et Br Cl Cl Et Br I Cl i-Pr Br Cl Cl i-Pr Br Cl Cl i-Pr Br I Cl t-Bu Br Cl Cl t-Bu Br Cl Cl t-Bu Br I Cl Me Br Cl Br Me Br Cl Br Me Br I Br Et Br Cl Br Et Br Cl Br Et Br I Br i-Pr Br Cl Br i-Pr Br Cl Br i-Pr Br I Br t-Bu Br Cl Br t-Bu Br Cl Br t-Bu Br I Br Me Br Br Cl Me Br Br Cl Me Br CF₃ Cl Et Br Br Cl Et Br Br Cl Et Br CF₃ Cl i-Pr Br Br Cl i-Pr Br Br Cl i-Pr Br CF₃ Cl t-Bu Br Br Cl t-Bu Br Br Cl t-Bu Br CF₃ Cl Me Br Br Br Me Br Br Br Me Br CF₃ Br Et Br Br Br Et Br Br Br Et Br CF₃ Br i-Pr Br Br Br i-Pr Br Br Br i-Pr Br CF₃ Br t-Bu Br Br Br t-Bu Br Br Br t-Bu Br CF₃ Br Me Br I Cl Me Br I Cl Me Cl Cl Br Et Br I Cl Et Br I Cl Et Cl Cl Br i-Pr Br I Cl i-Pr Br I Cl i-Pr Cl Cl Br t-Bu Br I Cl t-Bu Br I Cl t-Bu Cl Cl Br Me Br I Br Me Br I Br Me Cl Cl Cl Et Br I Br Et Br I Br Et Cl Cl Cl i-Pr Br I Br i-Pr Br I Br i-Pr Cl Cl Cl t-Bu Br I Br t-Bu Br I Br t-Bu Cl Cl Cl

TABLE 16

R⁵ is CHF₂ R⁵ is CH₂CF₃ R⁵ is CF₂CHF₂ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ Me CH₃ H Cl Me CH₃ H Cl Me CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl Me CH₃ H Br Me CH₃ H Br Me CH₃ H Br Et CH₃ H Br Et CH₃ H Br Et CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br Me CH₃ F Cl Me CH₃ F Cl Me CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl Me CH₃ F Br Me CH₃ F Br Me CH₃ F Br Et CH₃ F Br Et CH₃ F Br Et CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br Me CH₃ Cl Cl Me HC₃ Cl Cl Me CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl Me CH₃ Cl Br Me CH₃ Cl Br Me CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br Me CH₃ Br Cl Me CH₃ Br Cl Me CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl Me CH₃ Br Br Me CH₃ Br Br Me CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br Me CH₃ I Cl Me CH₃ I Cl Me CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl Me CH₃ I Br Me CH₃ I Br Me CH₃ I Br Et CH₃ I Br Et CH₃ I Br Et CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl Me CH₃ CF₃ Br Me CH₃ CF₃ Br Me CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br n-Pr CH₃ Cl Cl Me Cl F Br Me Cl H Br n-Bu CH₃ Cl Cl Et Cl F Br Et Cl H Br s-Bu CH₃ Cl Cl i-Pr Cl F Br i-Pr Cl H Br i-Bu CH₃ Cl Cl t-Bu Cl F Br t-Bu Cl H Br Me Cl F Cl Me Cl F Cl Me Cl H Cl Et Cl F Cl Et Cl F Cl Et Cl H Cl i-Pr Cl F Cl i-Pr Cl F Cl i-Pr Cl H Cl t-Bu Cl F Cl t-Bu Cl F Cl i-Pr Cl H Cl Me Cl F Br Me Cl Cl Br Me Cl I Br Et Cl F Br Et Cl Cl Br Et Cl I Br i-Pr Cl F Br i-Pr Cl Cl Br i-Pr Cl I Br t-Bu Cl F Br t-Bu Cl Cl Br t-Bu Cl I Br Me Cl Cl Cl Me Cl Cl Cl Me Cl I Cl Et Cl Cl Cl Et Cl Cl Cl Et Cl I Cl i-Pr Cl Cl Cl i-Pr Cl Cl Cl i-Pr Cl I Cl t-Bu Cl Cl Cl t-Bu Cl Cl Cl t-Bu Cl I Cl Me Cl H Br Me Cl H Br Me Cl F Br Et Cl H Br Et Cl H Br Et Cl F Br i-Pr Cl H Br i-Pr Cl H Br i-Pr Cl F Br t-Bu Cl H Br t-Bu Cl H Br t-Bu Cl F Br Me Cl H Cl Me Cl H Cl Me Cl F Cl Et Cl H Cl Et Cl H Cl Et Cl F Cl i-Pr Cl H Cl i-Pr Cl H Cl i-Pr Cl F Cl t-Bu Cl H Cl t-Bu Cl H Cl t-Bu Cl F Cl Me Cl Br Br Me Cl Br Br Me Cl CF₃ Br Et Cl Br Br Et Cl Br Br Et Cl CF₃ Br i-Pr Cl Br Br i-Pr Cl Br Br i-Pr Cl CF₃ Br t-Bu Cl Br Br t-Bu Cl Br Br t-Bu Cl CF₃ Br Me Cl Br Cl Me Cl I Cl Me Cl CF₃ Cl Et Cl Br Cl Et Cl I Cl Et Cl CF₃ Cl i-Pr Cl Br Cl i-Pr Cl I Cl i-Pr Cl CF₃ Cl t-Bu Cl Br Cl t-Bu Cl I Cl t-Bu Cl CF₃ Cl Me Cl I Br Me Cl I Br Me Br F Cl Et Cl I Br Et Cl I Br Et Br F Cl i-Pr Cl I Br i-Pr Cl I Br i-Pr Br F Cl t-Bu Cl I Br t-Bu Cl I Br t-Bu Br F Cl Me Cl I Cl Me Cl CF₃ Cl Me Br F Br Et Cl I Cl Et Cl CF₃ Cl Et Br F Br i-Pr Cl I Cl i-Pr Cl CF₃ Cl i-Pr Br F Br t-Bu Cl I Cl t-Bu Cl CF₃ Cl t-Bu Br F Br Me Cl CF₃ Br Me Cl CF₃ Br Me Br Cl Cl Et Cl CF₃ Br Et Cl CF₃ Br Et Br Cl Cl i-Pr Cl CF₃ Br i-Pr Cl CF₃ Br i-Pr Br Cl Cl t-Bu Cl CF₃ Br t-Bu Cl CF₃ Br t-Bu Br Cl Cl Me Cl CF₃ Cl n-Pr Cl Cl Cl Me Br Cl Br Et Cl CF₃ Cl n-Bu Cl Cl Cl Et Br Cl Br i-Pr Cl CF₃ Cl s-Bu Cl Cl Cl i-Pr Br Cl Br t-Bu Cl CF₃ Cl i-Bu Cl Cl Cl t-Bu Br Cl Br Me Br F Cl Me Br F Cl Me Br Br Cl Et Br F Cl Et Br F Cl Et Br Br Cl i-Pr Br F Cl i-Pr Br F Cl i-Pr Br Br Cl t-Bu Br F Cl t-Bu Br F Cl t-Bu Br Br Cl Me Br F Br Me Br F Br Me Br Br Br Et Br F Br Et Br F Br Et Br Br Br i-Pr Br F Br i-Pr Br F Br i-Pr Br Br Br t-Bu Br F Br t-Bu Br F Br t-Bu Br Br Br Me Br Cl Cl Me Br Cl Cl Me Br I Cl Et Br Cl Cl Et Br Cl Cl Et Br I Cl i-Pr Br Cl Cl i-Pr Br Cl Cl i-Pr Br I Cl t-Bu Br Cl Cl t-Bu Br Cl Cl t-Bu Br I Cl Me Br Cl Br Me Br Cl Br Me Br I Br Et Br Cl Br Et Br Cl Br Et Br I Br i-Pr Br Cl Br i-Pr Br Cl Br i-Pr Br I Br t-Bu Br Cl Br t-Bu Br Cl Br t-Bu Br I Br Me Br Br Cl Me Br Br Cl Me Br CF₃ Cl Et Br Br Cl Et Br Br Cl Et Br CF₃ Cl i-Pr Br Br Cl i-Pr Br Br Cl i-Pr Br CF₃ Cl t-Bu Br Br Cl t-Bu Br Br Cl t-Bu Br CF₃ Cl Me Br Br Br Me Br Br Br Me Br CF₃ Br Et Br Br Br Et Br Br Br Et Br CF₃ Br i-Pr Br Br Br i-Pr Br Br Br i-Pr Br CF₃ Br t-Bu Br Br Br t-Bu Br Br Br t-Bu Br CF₃ Br Me Br I Cl Me Br I Cl Me Cl Cl Br Et Br I Cl Et Br I Cl Et Cl Cl Br i-Pr Br I Cl i-Pr Br I Cl i-Pr Cl Cl Br t-Bu Br I Cl t-Bu Br I Cl t-Bu Cl Cl Br Me Br I Br Me Br I Br Me Cl Cl Cl Et Br I Br Et Br I Br Et Cl Cl Cl i-Pr Br I Br i-Pr Br I Br i-Pr Cl Cl Cl t-Bu Br I Br t-Bu Br I Br t-Bu Cl Cl Cl

TABLE 17

R⁵ is CHF₂ R⁵ is CH₂CF₃ R⁵ is CF₂CHF₂ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ Me CH₃ H Cl Me CH₃ H Cl Me CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl Et CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl Me CH₃ H Br Me CH₃ H Br Me CH₃ H Br Et CH₃ H Br Et CH₃ H Br Et CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ H Br Me CH₃ F Cl Me CH₃ F Cl Me CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl Et CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl i-Pr CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl t-Bu CH₃ F Cl Me CH₃ F Br Me CH₃ F Br Me CH₃ F Br Et CH₃ F Br Et CH₃ F Br Et CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br i-Pr CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br t-Bu CH₃ F Br Me CH₃ Cl Cl Me HC₃ Cl Cl Me CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl Et CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl Me CH₃ Cl Br Me CH₃ Cl Br Me CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br Et CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br Me CH₃ Br Cl Me CH₃ Br Cl Me CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl Et CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl i-Pr CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl t-Bu CH₃ Br Cl Me CH₃ Br Br Me CH₃ Br Br Me CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br Et CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br i-Pr CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br t-Bu CH₃ Br Br Me CH₃ I Cl Me CH₃ I Cl Me CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl Et CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl Me CH₃ I Br Me CH₃ I Br Me CH₃ I Br Et CH₃ I Br Et CH₃ I Br Et CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ I Br Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl Me CH₃ CF₃ Br Me CH₃ CF₃ Br Me CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br n-Pr CH₃ Cl Cl Me Cl F Br Me Cl H Br n-Bu CH₃ Cl Cl Et Cl F Br Et Cl H Br s-Bu CH₃ Cl Cl i-Pr Cl F Br i-Pr Cl H Br i-Bu CH₃ Cl Cl t-Bu Cl F Br t-Bu Cl H Br Me Cl F Cl Me Cl F Cl Me Cl H Cl Et Cl F Cl Et Cl F Cl Et Cl H Cl i-Pr Cl F Cl i-Pr Cl F Cl i-Pr Cl H Cl t-Bu Cl F Cl t-Bu Cl F Cl i-Pr Cl H Cl Me Cl F Br Me Cl Cl Br Me Cl I Br Et Cl F Br Et Cl Cl Br Et Cl I Br i-Pr Cl F Br i-Pr Cl Cl Br i-Pr Cl I Br t-Bu Cl F Br t-Bu Cl Cl Br t-Bu Cl I Br Me Cl Cl Cl Me Cl Cl Cl Me Cl I Cl Et Cl Cl Cl Et Cl Cl Cl Et Cl I Cl i-Pr Cl Cl Cl i-Pr Cl Cl Cl i-Pr Cl I Cl t-Bu Cl Cl Cl t-Bu Cl Cl Cl t-Bu Cl I Cl Me Cl H Br Me Cl H Br Me Cl F Br Et Cl H Br Et Cl H Br Et Cl F Br i-Pr Cl H Br i-Pr Cl H Br i-Pr Cl F Br t-Bu Cl H Br t-Bu Cl H Br t-Bu Cl F Br Me Cl H Cl Me Cl H Cl Me Cl F Cl Et Cl H Cl Et Cl H Cl Et Cl F Cl i-Pr Cl H Cl i-Pr Cl H Cl i-Pr Cl F Cl t-Bu Cl H Cl t-Bu Cl H Cl t-Bu Cl F Cl Me Cl Br Br Me Cl Br Br Me Cl CF₃ Br Et Cl Br Br Et Cl Br Br Et Cl CF₃ Br i-Pr Cl Br Br i-Pr Cl Br Br i-Pr Cl CF₃ Br t-Bu Cl Br Br t-Bu Cl Br Br t-Bu Cl CF₃ Br Me Cl Br Cl Me Cl I Cl Me Cl CF₃ Cl Et Cl Br Cl Et Cl I Cl Et Cl CF₃ Cl i-Pr Cl Br Cl i-Pr Cl I Cl i-Pr Cl CF₃ Cl t-Bu Cl Br Cl t-Bu Cl I Cl t-Bu Cl CF₃ Cl Me Cl I Br Me Cl I Br Me Br F Cl Et Cl I Br Et Cl I Br Et Br F Cl i-Pr Cl I Br i-Pr Cl I Br i-Pr Br F Cl t-Bu Cl I Br t-Bu Cl I Br t-Bu Br F Cl Me Cl I Cl Me Cl CF₃ Cl Me Br F Br Et Cl I Cl Et Cl CF₃ Cl Et Br F Br i-Pr Cl I Cl i-Pr Cl CF₃ Cl i-Pr Br F Br t-Bu Cl I Cl t-Bu Cl CF₃ Cl t-Bu Br F Br Me Cl CF₃ Br Me Cl CF₃ Br Me Br Cl Cl Et Cl CF₃ Br Et Cl CF₃ Br Et Br Cl Cl i-Pr Cl CF₃ Br i-Pr Cl CF₃ Br i-Pr Br Cl Cl t-Bu Cl CF₃ Br t-Bu Cl CF₃ Br t-Bu Br Cl Cl Me Cl CF₃ Cl n-Pr Cl Cl Cl Me Br Cl Br Et Cl CF₃ Cl n-Bu Cl Cl Cl Et Br Cl Br i-Pr Cl CF₃ Cl s-Bu Cl Cl Cl i-Pr Br Cl Br t-Bu Cl CF₃ Cl i-Bu Cl Cl Cl t-Bu Br Cl Br Me Br F Cl Me Br F Cl Me Br Br Cl Et Br F Cl Et Br F Cl Et Br Br Cl i-Pr Br F Cl i-Pr Br F Cl i-Pr Br Br Cl t-Bu Br F Cl t-Bu Br F Cl t-Bu Br Br Cl Me Br F Br Me Br F Br Me Br Br Br Et Br F Br Et Br F Br Et Br Br Br i-Pr Br F Br i-Pr Br F Br i-Pr Br Br Br t-Bu Br F Br t-Bu Br F Br t-Bu Br Br Br Me Br Cl Cl Me Br Cl Cl Me Br I Cl Et Br Cl Cl Et Br Cl Cl Et Br I Cl i-Pr Br Cl Cl i-Pr Br Cl Cl i-Pr Br I Cl t-Bu Br Cl Cl t-Bu Br Cl Cl t-Bu Br I Cl Me Br Cl Br Me Br Cl Br Me Br I Br Et Br Cl Br Et Br Cl Br Et Br I Br i-Pr Br Cl Br i-Pr Br Cl Br i-Pr Br I Br t-Bu Br Cl Br t-Bu Br Cl Br t-Bu Br I Br Me Br Br Cl Me Br Br Cl Me Br CF₃ Cl Et Br Br Cl Et Br Br Cl Et Br CF₃ Cl i-Pr Br Br Cl i-Pr Br Br Cl i-Pr Br CF₃ Cl t-Bu Br Br Cl t-Bu Br Br Cl t-Bu Br CF₃ Cl Me Br Br Br Me Br Br Br Me Br CF₃ Br Et Br Br Br Et Br Br Br Et Br CF₃ Br i-Pr Br Br Br i-Pr Br Br Br i-Pr Br CF₃ Br t-Bu Br Br Br t-Bu Br Br Br t-Bu Br CF₃ Br Me Br I Cl Me Br I Cl Me Cl Cl Br Et Br I Cl Et Br I Cl Et Cl Cl Br i-Pr Br I Cl i-Pr Br I Cl i-Pr Cl Cl Br t-Bu Br I Cl t-Bu Br I Cl t-Bu Cl Cl Br Me Br I Br Me Br I Br Me Cl Cl Cl Et Br I Br Et Br I Br Et Cl Cl Cl i-Pr Br I Br i-Pr Br I Br i-Pr Cl Cl Cl t-Bu Br I Br t-Bu Br I Br t-Bu Cl Cl Cl

TABLE 18

R⁵ is CHF₂ R⁵ is CH₂F₃ R⁵ is CHF₂ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ R² R^(4a) R^(4b) R⁶ Me CH₃ H Cl Me CH₃ H Cl Me CH₃ Br Cl Et CH₃ H Cl Et CH₃ H Cl Et CH₃ Br Cl i-Pr CH₃ H Cl i-Pr CH₃ H Cl i-Pr CH₃ Br Cl t-Bu CH₃ H Cl t-Bu CH₃ H Cl t-Bu CH₃ Br Cl Me CH₃ H Br Me CH₃ H Br Me CH₃ Br Br Et CH₃ H Br Et CH₃ H Br Et CH₃ Br Br i-Pr CH₃ H Br i-Pr CH₃ H Br i-Pr CH₃ Br Br t-Bu CH₃ H Br t-Bu CH₃ H Br t-Bu CH₃ Br Br Me CH₃ F Cl Me CH₃ Br Cl Me CH₃ I Cl Et CH₃ F Cl Et CH₃ Br Cl Et CH₃ I Cl i-Pr CH₃ F Cl i-Pr CH₃ Br Cl i-Pr CH₃ I Cl t-Bu CH₃ F Cl t-Bu CH₃ Br Cl t-Bu CH₃ I Cl Me CH₃ F Br Me CH₃ Br Br Me CH₃ I Br Et CH₃ F Br Et CH₃ Br Br Et CH₃ I Br i-Pr CH₃ F Br i-Pr CH₃ Br Br i-Pr CH₃ I Br t-Bu CH₃ F Br t-Bu CH₃ Br Br t-Bu CH₃ I Br Me CH₃ Cl Cl Me CH₃ F Cl Me CH₃ CF₃ Cl Et CH₃ Cl Cl Et CH₃ F Cl Et CH₃ CF₃ Cl i-Pr CH₃ Cl Cl i-Pr CH₃ F Cl i-Pr CH₃ CF₃ Cl t-Bu CH₃ Cl Cl t-Bu CH₃ F Cl t-Bu CH₃ CF₃ Cl Me CH₃ Cl Br Me CH₃ F Br Me CH₃ CF₃ Br Et CH₃ Cl Br Et CH₃ F Br Et CH₃ CF₃ Br i-Pr CH₃ Cl Br i-Pr CH₃ F Br i-Pr CH₃ CF₃ Br t-Bu CH₃ Cl Br t-Bu CH₃ F Br t-Bu CH₃ CF₃ Br Me CH₃ Br Cl Me CH₃ Cl Cl Me CH₃ Cl Cl Et CH₃ Br Cl Et CH₃ Cl Cl Et CH₃ Cl Cl i-Pr CH₃ Br Cl i-Pr CH₃ Cl Cl i-Pr CH₃ Cl Cl t-Bu CH₃ Br Cl t-Bu CH₃ Cl Cl t-Bu CH₃ Cl Cl Me CH₃ Br Br Me CH₃ Cl Br Me CH₃ Cl Br Et CH₃ Br Br Et CH₃ Cl Br Et CH₃ Cl Br i-Pr CH₃ Br Br i-Pr CH₃ Cl Br i-Pr CH₃ Cl Br t-Bu CH₃ Br Br t-Bu CH₃ Cl Br t-Bu CH₃ Cl Br Me CH₃ I Cl Me CH₃ I Cl Me CH₃ H Cl Et CH₃ I Cl Et CH₃ I Cl Et CH₃ H Cl i-Pr CH₃ I Cl i-Pr CH₃ I Cl i-Pr CH₃ H Cl t-Bu CH₃ I Cl t-Bu CH₃ I Cl t-Bu CH₃ H Cl Me CH₃ I Br Me CH₃ I Br Me CH₃ H Br Et CH₃ I Br Et CH₃ I Br Et CH₃ H Br i-Pr CH₃ I Br i-Pr CH₃ I Br i-Pr CH₃ H Br t-Bu CH₃ I Br t-Bu CH₃ I Br t-Bu CH₃ H Br Me CH₃ CF₃ Cl Me CH₃ CF₃ Cl Me CH₃ F Cl Et CH₃ CF₃ Cl Et CH₃ CF₃ Cl Et CH₃ F Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ CF₃ Cl i-Pr CH₃ F Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ CF₃ Cl t-Bu CH₃ F Cl Me CH₃ CF₃ Br Me CH₃ CF₃ Br Me CH₃ F Br Et CH₃ CF₃ Br Et CH₃ CF₃ Br Et CH₃ F Br i-Pr CH₃ CF₃ Br i-Pr CH₃ CF₃ Br i-Pr CH₃ F Br t-Bu CH₃ CF₃ Br t-Bu CH₃ CF₃ Br t-Bu CH₃ F Br n-Pr CH₃ Cl Cl Me Cl H Br Me Cl Cl Br n-Bu CH₃ Cl Cl Et Cl H Br Et Cl Cl Br s-Bu CH₃ Cl Cl i-Pr Cl H Br i-Pr Cl Cl Br i-Bu CH₃ Cl Cl t-Bu Cl H Br t-Bu Cl Cl Br Me Cl I Br Me Cl H Cl Me Cl Cl Cl Et Cl I Br Et Cl H Cl Et Cl Cl Cl i-Pr Cl I Br i-Pr Cl H Cl i-Pr Cl Cl Cl t-Bu Cl I Br t-Bu Cl H Cl t-Bu Cl Cl Cl Me Cl I Cl Me Cl Cl Br Me Cl I Br Et Cl I Cl Et Cl Cl Br Et Cl I Br i-Pr Cl I Cl i-Pr Cl Cl Br i-Pr Cl I Br t-Bu Cl I Cl t-Bu Cl Cl Br t-Bu Cl I Br Me Cl H Br Me Cl Cl Cl Me Cl I Cl Et Cl H Br Et Cl Cl Cl Et Cl I Cl i-Pr Cl H Br i-Pr Cl Cl Cl i-Pr Cl I Cl t-Bu Cl H Br t-Bu Cl Cl Cl t-Bu Cl I Cl Me Cl H Cl Me Cl F Br Me Cl F Br Et Cl H Cl Et Cl F Br Et Cl F Br i-Pr Cl H Cl i-Pr Cl F Br i-Pr Cl F Br t-Bu Cl H Cl t-Bu Cl F Br t-Bu Cl F Br Me Cl CF₃ Br Me Cl F Cl Me Cl F Cl Et Cl CF₃ Br Et Cl F Cl Et Cl F Cl i-Pr Cl CF₃ Br i-Pr Cl F Cl i-Pr Cl F Cl t-Bu Cl CF₃ Br t-Bu Cl F Cl t-Bu Cl F Cl Me Cl CF₃ Cl Me Cl Br Br Me Cl H Br Et Cl CF₃ Cl Et Cl Br Br Et Cl H Br i-Pr Cl CF₃ Cl i-Pr Cl Br Br i-Pr Cl H Br t-Bu Cl CF₃ Cl t-Bu Cl Br Br t-Bu Cl H Br Me Cl Br Br Me Cl I Cl Me Cl H Cl Et Cl Br Br Et Cl I Cl Et Cl H Cl i-Pr Cl Br Br i-Pr Cl I Cl i-Pr Cl H Cl t-Bu Cl Br Br t-Bu Cl I Cl i-Pr Cl H Cl Me Cl Br Cl Me Cl I Br Me Cl CF₃ Br Et Cl Br Cl Et Cl I Br Et Cl CF₃ Br i-Pr Cl Br Cl i-Pr Cl I Br i-Pr Cl CF₃ Br t-Bu Cl Br Cl t-Bu Cl I Br t-Bu Cl CF₃ Br Me Cl F Br Me Cl CF₃ Cl Me Cl CF₃ Cl Et Cl F Br Et Cl CF₃ Cl Et Cl CF₃ Cl i-Pr Cl F Br i-Pr Cl CF₃ Cl i-Pr Cl CF₃ Cl t-Bu Cl F Br t-Bu Cl CF₃ Cl t-Bu Cl CF₃ Cl Me Cl Cl Cl Me Cl CF₃ Br Me Br F Cl Et Cl Cl Cl Et Cl CF₃ Br Et Br F Cl i-Pr Cl Cl Cl i-Pr Cl CF₃ Br i-Pr Br F Cl t-Bu Cl Cl Cl t-Bu Cl CF₃ Br t-Bu Br F Cl Me Cl F Cl n-Pr Cl Cl Cl Me Br F Br Et Cl F Cl n-Bu Cl Cl Cl Et Br F Br i-Pr Cl F Cl s-Bu Cl Cl Cl i-Pr Br F Br t-Bu Cl F Cl i-Bu Cl Cl Cl t-Bu Br F Br Me Br Br Cl Me Br F Cl Me Br Cl Cl Et Br Br Cl Et Br F Cl Et Br Cl Cl i-Pr Br Br Cl i-Pr Br F Cl i-Pr Br Cl Cl t-Bu Br Br Cl t-Bu Br F Cl t-Bu Br Cl Cl Me Br Br Br Me Br F Br Me Br Cl Br Et Br Br Br Et Br F Br Et Br Cl Br i-Pr Br Br Br i-Pr Br F Br i-Pr Br Cl Br t-Bu Br Br Br t-Bu Br F Br t-Bu Br Cl Br Me Br I Cl Me Br Cl Cl Me Br Br Cl Et Br I Cl Et Br Cl Cl Et Br Br Cl i-Pr Br I Cl i-Pr Br Cl Cl i-Pr Br Br Cl t-Bu Br I Cl t-Bu Br Cl Cl t-Bu Br Br Cl Me Br I Br Me- Br Cl Br Me Br Br Br Et Br I Br Et Br Cl Br Et Br Br Br i-Pr Br I Br i-Pr Br Cl Br i-Pr Br Br Br t-Bu Br I Br t-Bu Br Cl Br t-Bu Br Br Br Me Br F Cl Me Br I Cl Me Br CF₃ Cl Et Br F Cl Et Br I Cl Et Br CF₃ Cl i-Pr Br F Cl i-Pr Br I Cl i-Pr Br CF₃ Cl t-Bu Br F Cl t-Bu Br I Cl t-Bu Br CF₃ Cl Me Br F Br Me Br I Br Me Br CF₃ Br Et Br F Br Et Br I Br Et Br CF₃ Br i-Pr Br F Br i-Pr Br I Br i-Pr Br CF₃ Br t-Bu Br F Br t-Bu Br I Br t-Bu Br CF₃ Br Me Br Cl Cl Me Br Br Cl Me Br I Cl Et Br Cl Cl Et Br Br Cl Et Br I Cl i-Pr Br Cl Cl i-Pr Br Br Cl i-Pr Br I Cl t-Bu Br Cl Cl t-Bu Br Br Cl t-Bu Br I Cl Me Br Cl Br Me Br Br Br Me Br I Br Et Br Cl Br Et Br Br Br Et Br I Br i-Pr Br Cl Br i-Pr Br Br Br i-Pr Br I Br t-Bu Br Cl Br t-Bu Br Br Br t-Bu Br I Br

TABLE 19

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl

TABLE 20

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ C1 Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl

TABLE 21

R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ R² R^(4a) R^(4b) R⁵ R⁶ Me CH₃ H CF₃ Cl Me Cl F CF₃ Cl Me Cl H Cl Br Et CH₃ H CF₃ Cl Et Cl F CF₃ Cl Et Cl H Cl Br i-Pr CH₃ H CF₃ Cl i-Pr Cl F CF₃ Cl i-Pr Cl H Cl Br t-Bu CH₃ H CF₃ Cl t-Bu Cl F CF₃ Cl t-Bu Cl H Cl Br Me CH₃ H CF₃ Br Me Cl F CF₃ Br Me Cl H Br Cl Et CH₃ H CF₃ Br Et Cl F CF₃ Br Et Cl H Br Cl i-Pr CH₃ H CF₃ Br i-Pr Cl F CF₃ Br i-Pr Cl H Br Cl t-Bu CH₃ H CF₃ Br t-Bu Cl F CF₃ Br t-Bu Cl H Br Cl Me CH₃ H Cl Cl Me Cl F Cl Cl Me Cl H Br Br Et CH₃ H Cl Cl Et Cl F Cl Cl Et Cl H Br Br i-Pr CH₃ H Cl Cl i-Pr Cl F Cl Cl i-Pr Cl H Br Br t-Bu CH₃ H Cl Cl t-Bu Cl F Cl Cl t-Bu Cl H Br Br Me CH₃ H Cl Br Me Cl F Cl Br Me Cl H CF₃ Cl Et CH₃ H Cl Br Et Cl F Cl Br Et Cl H CF₃ Cl i-Pr CH₃ H Cl Br i-Pr Cl F Cl Br i-Pr Cl H CF₃ Cl t-Bu CH₃ H Cl Br t-Bu Cl F Cl Br t-Bu Cl H CF₃ Cl Me CH₃ H Br Cl Me Cl F Br Cl Me Cl H CF₃ Br Et CH₃ H Br Cl Et Cl F Br Cl Et Cl H CF₃ Br i-Pr CH₃ H Br Cl i-Pr Cl F Br Cl i-Pr Cl H CF₃ Br t-Bu CH₃ H Br Cl t-Bu Cl F Br Cl t-Bu Cl H CF₃ Br Me CH₃ H Br Br Me Cl F Br Br Me Cl H Cl Cl Et CH₃ H Br Br Et Cl F Br Br Et Cl H Cl Cl i-Pr CH₃ H Br Br i-Pr Cl F Br Br i-Pr Cl H Cl Cl t-Bu CH₃ H Br Br t-Bu Cl F Br Br i-Pr Cl H Cl Cl Me CH₃ F CF₃ Cl Me Cl Cl CF₃ Cl Me Cl Br Cl Br Et CH₃ F CF₃ Cl Et Cl Cl CF₃ Cl Et Cl Br Cl Br i-Pr CH₃ F CF₃ Cl i-Pr Cl Cl CF₃ Cl i-Pr Cl Br Cl Br t-Bu CH₃ F CF₃ Cl t-Bu Cl Cl CF₃ Cl t-Bu Cl Br Cl Br Me CH₃ F CF₃ Br Me Cl Cl CF₃ Br Me Cl Br Br Cl Et CH₃ F CF₃ Br Et Cl Cl CF₃ Br Et Cl Br Br Cl i-Pr CH₃ F CF₃ Br i-Pr Cl Cl CF₃ Br i-Pr Cl Br Br Cl t-Bu CH₃ F CF₃ Br t-Bu Cl Cl CF₃ Br t-Bu Cl Br Br Cl Me CH₃ F Cl Cl Me Cl Cl Cl Cl Me Cl Br Br Br Et CH₃ F Cl Cl Et Cl Cl Cl Cl Et Cl Br Br Br i-Pr CH₃ F Cl Cl i-Pr Cl Cl Cl Cl i-Pr Cl Br Br Br t-Bu CH₃ F Cl Cl t-Bu Cl Cl Cl Cl t-Bu Cl Br Br Br Me CH₃ F Cl Br Me Cl Cl Cl Br Me Cl I CF₃ Cl Et CH₃ F Cl Br Et Cl Cl Cl Br Et Cl I CF₃ Cl i-Pr CH₃ F Cl Br i-Pr Cl Cl Cl Br i-Pr Cl I CF₃ Cl t-Bu CH₃ F Cl Br t-Bu Cl Cl Cl Br t-Bu Cl I CF₃ Cl Me CH₃ F Br Cl Me Cl Cl Br Cl Me Cl I CF₃ Br Et CH₃ F Br Cl Et Cl Cl Br Cl Et Cl I CF₃ Br i-Pr CH₃ F Br Cl i-Pr Cl Cl Br Cl i-Pr Cl I CF₃ Br t-Bu CH₃ F Br Cl t-Bu Cl Cl Br Cl t-Bu Cl I CF₃ Br Me CH₃ F Br Br Me Cl Cl Br Br Me Cl I Cl Cl Et CH₃ F Br Br Et Cl Cl Br Br Et Cl I Cl Cl i-Pr CH₃ F Br Br i-Pr Cl Cl Br Br i-Pr Cl I Cl Cl t-Bu CH₃ F Br Br t-Bu Cl Cl Br Br t-Bu Cl I Cl Cl Me CH₃ Cl CF₃ Cl Me Cl Br CF₃ Cl Me Cl I Cl Br Et CH₃ Cl CF₃ Cl Et Cl Br CF₃ Cl Et Cl I Cl Br i-Pr CH₃ Cl CF₃ Cl i-Pr Cl Br CF₃ Cl i-Pr Cl I Cl Br t-Bu CH₃ Cl CF₃ Cl t-Bu Cl Br CF₃ Cl t-Bu Cl I Cl Br Me CH₃ Cl CF₃ Br Me Cl Br CF₃ Br Me Cl I Br Cl Et CH₃ Cl CF₃ Br Et Cl Br CF₃ Br Et Cl I Br Cl i-Pr CH₃ Cl CF₃ Br i-Pr Cl Br CF₃ Br i-Pr Cl I Br Cl t-Bu CH₃ Cl CF₃ Br t-Bu Cl Br CF₃ Br t-Bu Cl I Br Cl Me CH₃ Cl Cl Cl Me Cl Br Cl Cl Me Cl I Br Br Et CH₃ Cl Cl Cl Et Cl Br Cl Cl Et Cl I Br Br i-Pr CH₃ Cl Cl Cl i-Pr Cl Br Cl Cl i-Pr Cl I Br Br t-Bu CH₃ Cl Cl Cl t-Bu Cl Br Cl Cl t-Bu Cl I Br Br Me CH₃ Cl Cl Br Me Br Br Br Cl Me Cl CF₃ CF₃ Cl Et CH₃ Cl Cl Br Et Br Br Br Cl Et Cl CF₃ CF₃ Cl i-Pr CH₃ Cl Cl Br i-Pr Br Br Br Cl i-Pr Cl CF₃ CF₃ Cl t-Bu CH₃ Cl Cl Br t-Bu Br Br Br Cl t-Bu Cl CF₃ CF₃ Cl Me CH₃ Cl Br Cl Me Br Br Br Br Me Cl CF₃ CF₃ Br Et CH₃ Cl Br Cl Et Br Br Br Br Et Cl CF₃ CF₃ Br i-Pr CH₃ Cl Br Cl i-Pr Br Br Br Br i-Pr Cl CF₃ CF₃ Br t-Bu CH₃ Cl Br Cl t-Bu Br Br Br Br t-Bu Cl CF₃ CF₃ Br Me CH₃ Cl Br Br Me Br I CF₃ Cl Me Cl CF₃ Cl Cl Et CH₃ Cl Br Br Et Br I CF₃ Cl Et Cl CF₃ Cl Cl i-Pr CH₃ Cl Br Br i-Pr Br I CF₃ Cl i-Pr Cl CF₃ Cl Cl t-Bu CH₃ Cl Br Br t-Bu Br I CF₃ Cl t-Bu Cl CF₃ Cl Cl Me CH₃ Br CF₃ Cl Me Br I CF₃ Br Me Cl CF₃ Cl Br Et CH₃ Br CF₃ Cl Et Br I CF₃ Br Et Cl CF₃ Cl Br i-Pr CH₃ Br CF₃ Cl i-Pr Br I CF₃ Br i-Pr Cl CF₃ Cl Br t-Bu CH₃ Br CF₃ Cl t-Bu Br I CF₃ Br t-Bu Cl CF₃ Cl Br Me CH₃ Br CF₃ Br Me Br I Cl Cl Me Cl CF₃ Br Cl Et CH₃ Br CF₃ Br Et Br I Cl Cl Et Cl CF₃ Br Cl i-Pr CH₃ Br CF₃ Br i-Pr Br I Cl Cl i-Pr Cl CF₃ Br Cl t-Bu CH₃ Br CF₃ Br t-Bu Br I Cl Cl t-Bu Cl CF₃ Br Cl Me CH₃ Br Cl Cl Me Br I Cl Br Me Cl CF₃ Br Br Et CH₃ Br Cl Cl Et Br I Cl Br Et Cl CF₃ Br Br i-Pr CH₃ Br Cl Cl i-Pr Br I Cl Br i-Pr Cl CF₃ Br Br t-Bu CH₃ Br Cl Cl t-Bu Br I Cl Br t-Bu Cl CF₃ Br Br Me CH₃ Br Cl Br Me Br I Br Cl n-Pr Cl Cl Cl Cl Et CH₃ Br Cl Br Et Br I Br Cl n-Bu Cl Cl Cl Cl i-Pr CH₃ Br Cl Br i-Pr Br I Br Cl s-Bu Cl Cl Cl Cl t-Bu CH₃ Br Cl Br t-Bu Br I Br Cl i-Bu Cl Cl Cl Cl Me CH₃ Br Br Cl Me Br I Br Br Me Br F CF₃ Cl Et CH₃ Br Br Cl Et Br I Br Br Et Br F CF₃ Cl i-Pr CH₃ Br Br Cl i-Pr Br I Br Br i-Pr Br F CF₃ Cl t-Bu CH₃ Br Br Cl t-Bu Br I Br Br t-Bu Br F CF₃ Cl Me CH₃ Br Br Br Me Br CF₃ CF₃ Cl Me Br F CF₃ Br Et CH₃ Br Br Br Et Br CF₃ CF₃ Cl Et Br F CF₃ Br i-Pr CH₃ Br Br Br i-Pr Br CF₃ CF₃ Cl i-Pr Br F CF₃ Br t-Bu CH₃ Br Br Br t-Bu Br CF₃ CF₃ Cl t-Bu Br F CF₃ Br Me CH₃ I CF₃ Cl Me Br CF₃ CF₃ Br Me Br F Cl Cl Et CH₃ I CF₃ Cl Et Br CF₃ CF₃ Br Et Br F Cl Cl i-Pr CH₃ I CF₃ Cl i-Pr Br CF₃ CF₃ Br i-Pr Br F Cl Cl t-Bu CH₃ I CF₃ Cl t-Bu Br CF₃ CF₃ Br t-Bu Br F Cl Cl Me CH₃ I CF₃ Br Me Br CF₃ Cl Cl Me Br F Cl Br Et CH₃ I CF₃ Br Et Br CF₃ Cl Cl Et Br F Cl Br i-Pr CH₃ I CF₃ Br i-Pr Br CF₃ Cl Cl i-Pr Br F Cl Br t-Bu CH₃ I CF₃ Br t-Bu Br CF₃ Cl Cl t-Bu Br F Cl Br Me CH₃ I Cl Cl Me Br CF₃ Cl Br Me Br F Br Cl Et CH₃ I Cl Cl Et Br CF₃ Cl Br Et Br F Br Cl i-Pr CH₃ I Cl Cl i-Pr Br CF₃ Cl Br i-Pr Br F Br Cl t-Bu CH₃ I Cl Cl t-Bu Br CF₃ Cl Br t-Bu Br F Br Cl Me CH₃ I Cl Br Me Br CF₃ Br Cl Me Br F Br Br Et CH₃ I Cl Br Et Br CF₃ Br Cl Et Br F Br Br i-Pr CH₃ I Cl Br i-Pr Br CF₃ Br Cl i-Pr Br F Br Br t-Bu CH₃ I Cl Br t-Bu Br CF₃ Br Cl t-Bu Br F Br Br Me CH₃ I Br Cl Me Br CF₃ Br Br Me Br Cl CF₃ Cl Et CH₃ I Br Cl Et Br CF₃ Br Br Et Br Cl CF₃ Cl i-Pr CH₃ I Br Cl i-Pr Br CF₃ Br Br i-Pr Br Cl CF₃ Cl t-Bu CH₃ I Br Cl t-Bu Br CF₃ Br Br t-Bu Br Cl CF₃ Cl Me CH₃ I Br Br Me Br Br CF₃ Cl Me Br Cl CF₃ Br Et CH₃ I Br Br Et Br Br CF₃ Cl Et Br Cl CF₃ Br i-Pr CH₃ I Br Br i-Pr Br Br CF₃ Cl i-Pr Br Cl CF₃ Br t-Bu CH₃ I Br Br t-Bu Br Br CF₃ Cl t-Bu Br Cl CF₃ Br Me CH₃ CF₃ CF₃ Cl Me Br Br CF₃ Br Me Br Cl Cl Cl Et CH₃ CF₃ CF₃ Cl Et Br Br CF₃ Br Et Br Cl Cl Cl i-Pr CH₃ CF₃ CF₃ Cl i-Pr Br Br CF₃ Br i-Pr Br Cl Cl Cl t-Bu CH₃ CF₃ CF₃ Cl t-Bu Br Br CF₃ Br t-Bu Br Cl Cl Cl Me CH₃ CF₃ CF₃ Br Me Br Br Cl Cl Me Br Cl Cl Br Et CH₃ CF₃ CF₃ Br Et Br Br Cl Cl Et Br Cl Cl Br i-Pr CH₃ CF₃ CF₃ Br i-Pr Br Br Cl Cl i-Pr Br Cl Cl Br t-Bu CH₃ CF₃ CF₃ Br t-Bu Br Br Cl Cl t-Bu Br Cl Cl Br Me CH₃ CF₃ Cl Cl Me Br Br Cl Br Me Br Cl Br Cl Et CH₃ CF₃ Cl Cl Et Br Br Cl Br Et Br Cl Br Cl i-Pr CH₃ CF₃ Cl Cl i-Pr Br Br Cl Br i-Pr Br Cl Br Cl t-Bu CH₃ CF₃ Cl Cl t-Bu Br Br Cl Br t-Bu Br Cl Br Cl Me CH₃ CF₃ Cl Br Me CH₃ CF₃ Br Cl Me Br Cl Br Br Et CH₃ CF₃ Cl Br Et CH₃ CF₃ Br Cl Et Br Cl Br Br i-Pr CH₃ CF₃ Cl Br i-Pr CH₃ CF₃ Br Cl i-Pr Br Cl Br Br t-Bu CH₃ CF₃ Cl Br t-Bu CH₃ CF₃ Br Cl t-Bu Br Cl Br Br Me CH₃ CF₃ Br Br n-Pr CH₃ Cl Cl Cl t-Bu CH₃ CF₃ Br Br Et CH₃ CF₃ Br Br n-Bu CH₃ Cl Cl Cl i-Bu CH₃ Cl Cl Cl i-Pr CH₃ CF₃ Br Br s-Bu CH₃ Cl Cl Cl Formulation/Utility

Compounds used in accordance with this invention will generally be used as a formulation or composition with an agriculturally suitable carrier comprising at least one of a liquid diluent, a solid diluent or a surfactant. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature. Useful formulations include liquids such as solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions and/or suspoemulsions) and the like which optionally can be thickened into gels. Useful formulations further include solids such as dusts, powders, granules, pellets, tablets, films, and the like which can be water-dispersible (“wettable”) or water-soluble. Active ingredient can be (micro)-encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or “overcoated”). Encapsulation can control or delay release of the active ingredient. Sprayable formulations can be extended in suitable media and used at spray volumes from about one to several hundred liters per hectare. High-strength compositions are primarily used as intermediates for further formulation.

The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges that add up to 100 percent by weight.

Weight Percent Active Sur- Ingredient Diluent factant Water-Dispersible and Water-soluble 5–90  0–94 1–15 Granules, Tablets and Powders. Suspensions, Emulsions, Solutions 5–50 40–95 0–15 (including Emulsifiable Concentrates) Dusts 1–25 70–99 0–5  Granules and Pellets 0.01–99    5–99.99 0–15 High Strength Compositions 90–99   0–10 0–2 

Typical solid diluents are described in Watkins, et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, N.J. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950. McCutcheon's Detergents and Emulsifiers Annual, Allured Publ. Corp., Ridgewood, N.J., as well as Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth and the like, or thickeners to increase viscosity.

Surfactants include, for example, polyethoxylated alcohols, polyethoxylated alkylphenols, polyethoxylated sorbitan fatty acid esters, dialkyl sulfosuccinates, alkyl sulfates, alkylbenzene sulfonates, organosilicones, N,N-dialkyltaurates, lignin sulfonates, naphthalene sulfonate formaldehyde condensates, polycarboxylates, and polyoxyethylenelpolyoxypropylene block copolymers. Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, starch, sugar, silica, talc, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Liquid diluents include, for example, water, N,N-dimethylformamide, dimethyl sulfoxide, N-alkylpyrrolidone, ethylene glycol, polypropylene glycol, paraffins, alkylbenzenes, alkylnaphthalenes, oils of olive, castor, linseed, tung, sesame, corn, peanut, cotton-seed, soybean, rape-seed and coconut, fatty acid esters, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, and alcohols such as methanol, cyclohexanol, decanol and tetrahydrofurfuryl alcohol.

Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. Dusts and powders can be prepared by blending and, usually, grinding as in a hammer mill or fluid-energy mill. Suspensions are usually prepared by wet-milling; see, for example, U.S. Pat. No. 3,060,084. Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, “Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147–48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8–57 and following, and PCT Publication WO 91/13546. Pellets can be prepared as described in U.S. Pat. No. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. Pat. Nos. 4,144,050, 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. Pat. Nos. 5,180,587, 5,232,701 and 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.

For further information regarding the art of formulation, see T. S. Woods, “The Formulator's Toolbox—Product Forms for Modern Agriculture” in Pesticide Chemistry and Bioscience, The Food—Environment Challenge, T. Brooks and T. R Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120–133. See also U.S. Pat. No. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10–41; U.S. Pat. No. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138–140, 162–164, 166, 167 and 169–182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1–4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81–96; and Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989.

In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Table A.

EXAMPLE A

Wettable Powder Compound 4 65.0% dodecylphenol polyethylene glycol ether  2.0% sodium ligninsulfonate  4.0% sodium silicoaluminate  6.0% montmorillonite (calcined) 23.0%.

EXAMPLE B

Granule Compound 4 10.0% attapulgite granules (low volatile matter, 90.0%. 0.71/0.30 mm; U.S.S. No. 25–50 sieves)

EXAMPLE C

Extruded Pellet Compound 4 25.0% anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate  5.0% sodium alkylnaphthalenesulfonate  1.0% calcium/magnesium bentonite 59.0%.

EXAMPLE D

Emulsifiable Concentrate Compound 4 20.0% blend of oil soluble sulfonates 10.0% and polyoxyethylene ethers isophorone 70.0%.

EXAMPLE E

Granule Compound 4  0.5% cellulose  2.5% lactose  4.0% cornmeal 93.0%.

Compounds used in accordance with this invention are characterized by favorable metabolic and/or soil residual patterns and exhibit activity controlling a spectrum of agronomic and non-agronomic invertebrate pests. (In the context of this disclosure “invertebrate pest control” means inhibition of invertebrate pest development (including mortality) that causes significant reduction in feeding or other injury or damage caused by the pest; related expressions are defined analogously.) As referred to in this disclosure, the term “invertebrate pest” includes arthropods, gastropods and nematodes of economic importance as pests. The term “arthropod” includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans. The term “gastropod” includes snails, slugs and other Stylommatophora. The term “nematode” includes all of the helminths, such as: roundworms, heartworms, and phytophagous nematodes (Nematoda), flukes (Tematoda), Acanthocephala, and tapeworms (Cestoda). Those skilled in the art will recognize that not all compounds are equally effective against all pests. Compounds used in accordance with this invention display activity against economically important agronomic and nonagronomic pests. The term “agronomic” refers to the production of field crops such as for food and fiber and includes the growth of cereal crops (e.g., wheat, oats, barley, rye, rice, maize), soybeans, vegetable crops (e.g., lettuce, cabbage, tomatoes, beans), potatoes, sweet potatoes, grapes, cotton, and tree fruits (e.g., pome fruits, stone fruits and citrus fruits). The term “nonagronomic” refers to other horticultural (e.g., forest, greenhouse, nursery or ornamental plants not grown in a field), public (human) and animal health, domestic and commercial structure, household, and stored product applications or pests. For reason of invertebrate pest control spectrum and economic importance, protection (from damage or injury caused by invertebrate pests) of agronomic crops of cotton, maize, soybeans, rice, vegetable crops, potato, sweet potato, grapes and tree fruit by controlling invertebrate pests are preferred embodiments of the invention. Agronomic or nonagronomic pests include larvae of the order Lepidoptera, such as armyworms, cutworms, loopers, and heliothines in the family Noctuidae (e.g., fall armyworm (Spodoptera fugiperda J. E. Smith), beet armyworm (Spodoptera exigua Hübner), black cutworm (Agrotis epsilon Hufnagel), cabbage looper (Trichoplusia ni Hübner), tobacco budworm (Heliothis virescens Fabricius)); borers, casebearers, webworms, coneworms, cabbageworms and skeletonizers from the family Pyralidae (e.g., European corn borer (Ostrinia nubilalis Hübner), navel orangeworm (Amyelois transitella Walker), corn root webworm (Crambus caliginosellus Clemens), sod webworm (Herpetogramma licarsisalis Walker)); leafrollers, budworms, seed worms, and fruit worms in the family Tortricidae (e.g., codling moth (Cydia pomonella Linnaeus), grape berry moth (Endopiza viteana Clemens), oriental fruit moth (Grapholita molesta Busck)); and many other economically important lepidoptera (e.g., diamondback moth (Plutella xylostella Linnaeus), pink bollworm (Pectinophora gossypiella Saunders), gypsy moth (Lymantria dispar Linnaeus)); nymphs and adults of the order Blattodea including cockroaches from the families Blattellidae and Blattidae (e.g., oriental cockroach (Blatta orientalis Linnaeus), Asian cockroach (Blatella asahinai Mizukubo), German cockroach (Blattella germanica Linnaeus), brownbanded cockroach (Supella longipalpa Fabricius), American cockroach (Periplaneta americana Linnaeus), brown cockroach (Periplaneta brunnea Burmeister), Madeira cockroach (Leucophaea maderae Fabricius)); foliar feeding larvae and adults of the order Coleoptera including weevils from the families Anthribidae, Bruchidae, and Curculionidae (e.g., boll weevil (Anthonomus grandis Boheman), rice water weevil (Lissorhoptius oryzophilus Kuschel), granary weevil (Sitophilus granarius Linnaeus), rice weevil (Sitophilus oryzae Linnaeus)); flea beetles, cucumber beetles, rootworms, leaf beetles, potato beetles, and leafminers in the family Chrysomelidae (e.g., Colorado potato beetle (Leptinotarsa decemlineata Say), western corn rootworm (Diabrotica virgifera virgifera LeConte)); chafers and other beetles from the family Scaribaeidae (e.g., Japanese beetle (Popillia japonica Newman) and European chafer (Rhizotrogus majalis Razoumowsky)); carpet beetles from the family Dermestidae; wireworms from the family Elateridae; bark beetles from the family Scolytidae and flour beetles from the family Tenebrionidae. In addition agronomic and nonagronomic pests include: adults and larvae of the order Dermaptera including earwigs from the family Forficulidae (e.g., European earwig (Forficula auricularia Linnaeus), black earwig (Chelisoches morio Fabricius)); adults and nymphs of the orders Hemiptera and Homoptera such as, plant bugs from the family Miridae, cicadas from the family Cicadidae, leafhoppers (e.g. Empoasca spp.) from the family Cicaderidae, planthoppers from the families Fulgoroidae and Delphacidae, treehoppers from the family Membracidae, psyllids from the family Psyllidae, whiteflies from the family Aleyrodidae, aphids from the family Aphididae, phylloxera from the family Phylloxeridae, mealybugs from the family Pseudococcidae, scales from the families Coccidae, Diaspididae and Margarodidae, lace bugs from the family Tingidae, stink bugs from the family Pentatomidae, cinch bugs (e.g., Blissus spp.) and other seed bugs from the family Lygaeidae, spittlebugs from the family Cercopidae squash bugs from the family Coreidae, and red bugs and cotton stainers from the family Pyrrhocoridae. Also included are adults and larvae of the order Acari (mites) such as spider mites and red mites in the family Tetranychidae (e.g., European red mite (Panonychus ulmi Koch), two spotted spider mite (Tetranychus urticae Koch), McDaniel mite (Tetranychus mcdanieli McGregor)), flat mites in the family Tenuipalpidae (e.g., citrus flat mite (Brevipalpus lewisi McGregor)), rust and bud mites in the family Eriophyidae and other foliar feeding mites and mites important in human and animal health, i.e. dust mites in the family Epidermoptidae, follicle mites in the family Demodicidae, grain mites in the family Glycyphagidae, ticks in the order Ixodidae (e.g., deer tick (Ixodes scapularis Say), Australian paralysis tick (Ixodes holocyclus Neumann), American dog tick (Dermacentor variabilis Say), lone star tick (Amblyomma americanum Linnaeus) and scab and itch mites in the families Psoroptidae, Pyemotidae, and Sarcoptidae; adults and immatures of the order Orthoptera including grasshoppers, locusts and crickets (e.g., migratory grasshoppers (e.g., Melanoplus sanguinipes Fabricius, M. differentialis Thomas), American grasshoppers (e.g., Schistocerca americana Drury), desert locust (Schistocerca gregaria Forskal), migratory locust (Locusta migratoria Linnaeus), house cricket (Acheta domesticus Linnaeus), mole crickets (Gryllotalpa spp.)); adults and immatures of the order Diptera including leafminers, midges, fruit flies (Tephritidae), frit flies (e.g., Oscinella frit Linnaeus), soil maggots, house flies (e.g., Musca domestica Linnaeus), lesser house flies (e.g., Fannia caniculais Linnaeus, F. femoralis Stein), stable flies (e.g., Stomoxys calcitrans Linnaeus), face flies, horn flies, blow flies (e.g., Chrysomya spp., Phormia spp.), and other muscoid fly pests, horse flies (e.g., Tabanus spp.), bot flies (e.g., Gastrophilus spp., Oestrus spp.), cattle grubs (e.g., Hypoderma spp.), deer flies (e.g., Chrysops spp.), keds (e.g., Melophagus ovinus Linnaeus) and other Brachycera, mosquitoes (e.g., Aedes spp., Anopheles spp., Culex spp.), black flies (e.g., Prosimulium spp., Simulium spp.), biting midges, sand flies, sciarids, and other Nematocera; adults and immatures of the order Thysanoptera including onion thrips (Thrips tabaci Lindeman) and other foliar feeding thrips; insect pests of the order Hymenoptera including ants (e.g., red carpenter ant (Camponotus ferrugineus Fabricius), black carpenter ant (Camponotus pennsylvanicus De Geer), Pharaoh ant (Monomorium pharaonis Linnaeus), little fire ant (Wasmannia auropunctata Roger), fire ant (Solenopsis geminata Fabricius), red imported fire ant (Solenopsis invicta Buren), Argentine ant (Iridomyrmex humilis Mayr), crazy ant (Paratrechina longicornis Latreille), pavement ant (Tetramorium caespitum Linnaeus), cornfield ant (Lasius alienus Förster), odorous house ant (Tapinoma sessile Say)), bees (including carpenter bees), hornets, yellow jackets and wasps; insect pests of the order Isoptera including the eastern subterranean termite (Reticulitermes flavipes Kollar), western subterranean termite (Reticulitermes hesperus Banks), Formosan subterranean termite (Coptotermes formosanus Shiraki), West Indian drywood termite (Incisitermes immigrans Snyder) and other termites of economic importance; insect pests of the order Thysanura such as silverfish (Lepisma saccharina Linnaeus) and firebrat (Thermobia domestica Packard); insect pests of the order Mallophaga and including the head louse (Pediculus humanus capitis De Geer), body louse (Pediculus humanus humanus Linnaeus), chicken body louse (Menacanthus stramineus Nitszch), dog biting louse (Trichodectes canis De Geer), fluff louse (Goniocotes gallinae De Geer), sheep body louse (Bovicola ovis Scerank), short-nosed cattle louse (Haematopinus eurysternus Nitzsch), long-nosed cattle louse (Linognathus vituli Linnaeus) and other sucking and chewing parasitic lice that attack man and animals; insect pests of the order Siphonoptera including the oriental rat flea (Xenopsylla cheopis Rothschild), cat flea (Ctenocephalides felis Bouche), dog flea (Ctenocephalides canis Curtis), hen flea (Ceratophyllus gallinae Schrank), sticktight flea (Echidnophaga gallinacea Westwood), human flea (Pulex irritans Linnaeus) and other fleas afflicting mammals and birds. Additional arthropod pests covered include: spiders in the order Araneae such as the brown recluse spider (Loxosceles reclusa Gertsch & Mulaik) and the black widow spider (Latrodectus mactans Fabricius), and centipedes in the order Scutigeromorpha such as the house centipede (Scutigera coleoptrata Linnaeus). Compounds of the present invention also have activity on members of the Classes Nematoda, Cestoda, Trematoda, and Acanthocephala including economically important members of the orders Strongylida, Ascaridida, Oxyurida, Rhabditida, Spirurida, and Enoplida such as but not limited to economically important agricultural pests (i.e. root knot nematodes in the genus Meloidogyne, lesion nematodes in the genus Pratylenchus, stubby root nematodes in the genus Trichodorus, etc.) and animal and human health pests (i.e. all economically important flukes, tapeworms, and roundworms, such as Strongylus vulgaris in horses, Toxocara canis in dogs, Haemonchus contortus in sheep, Dirofilaria immitis Leidy in dogs, Anoplocephala perfoliata in horses, Fasciola hepatica Linnaeus in ruminants, etc.).

Compounds of the invention show particularly high activity against pests in the order Lepidoptera (e.g., Alabama argillacea Hübner (cotton leaf worm), Archips argyrospila Walker (fruit tree leaf roller), A. rosana Linnaeus (European leaf roller) and other Archips species, Chilo suppressalis Walker (rice stem borer), Cnaphalocrosis medinalis Guenee (rice leaf roller), Crambus caliginosellus Clemens (corn root webworm), Crambus teterrellus Zincken (bluegrass webworm), Cydia pomonella Linnaeus (codling moth), Earias insulana Boisduval (spiny bollworm), Earias vittella Fabricius (spotted bollworm), Helicoverpa armigera Hübner (American bollworm), Helicoverpa zea Boddie (corn earworm), Heliothis virescens Fabricius (tobacco budworm), Herpetogramma licarsisalis Walker (sod webworm), Lobesia botrana Denis & Schiffermüller (grape berry moth), Pectinophora gossypiella Saunders (pink bollworm), Phyllocnistis citrella Stainton (citrus leafminer), Pieris brassicae Linnaeus (large white butterfly), Pieris rapae Linnaeus (small white butterfly), Plutella xylostella Linnaeus (diamondback moth), Spodoptera exigua Hübner (beet armyworm), Spodoptera litura Fabricius (tobacco cutworm, cluster caterpillar), Spodoptera frugiperda J. E. Smith (fall armyworm), Tichoplusia ni Hübner (cabbage looper) and Tuta absoluta Meyrick (tomato leafminer)). Compounds of the invention also have commercially significant activity on members from the order Homoptera including: Acyrthisiphon pisum Harris (pea aphid), Aphis craccivora Koch (cowpea aphid), Aphis fabae Scopoli (black bean aphid), Aphis gossypii Glover (cotton aphid, melon aphid), Aphis pomi De Geer (apple aphid), Aphis spiraecola Patch (spirea aphid), Aulacorthum solani Kaltenbach (foxglove aphid), Chaetosiphon fragaefolii Cockerell (strawberry aphid), Diuraphis noxia Kurdjumov/Mordvilko (Russian wheat aphid), Dysaphis plantaginea Paaserini (rosy apple aphid), Eriosoma lanigerum Hausmann (woolly apple aphid), Hyalopterus pruni Geoffroy (mealy plum aphid), Lipaphis erysimi Kaltenbach (turnip aphid), Metopolophium dirrhodum Walker (cereal aphid), Macrosipum euphorbiae Thomas (potato aphid), Myzus persicae Sulzer (peach-potato aphid, green peach aphid), Nasonovia ribisnigri Mosley (lettuce aphid), Pemphigus spp. (root aphids and gall aphids), Rhopalosiphum maidis Fitch (corn leaf aphid), Rhopalosiphum padi Linnaeus (bird cherry-oat aphid), Schizaphis graminuin Rondani (greenbug), Sitobion avenae Fabricins (English grain aphid), Therioaphis maculata Buckton (spotted alfalfa aphid), Toxoptera aurantil Boyer de Fonscolombe (black citrus aphid), and Toxoptera citricida Kirkaldy (brown citus aphid); Adelges spp. (adelgids); Phylloxera devastatrix Pergande (pecan phylloxera); Bentisia tabaci Gennadius (tobacco whitefly, sweetpotato whitefly), Bemisia argentifolii Bellows & Perring (silverleaf whitefly), Dialeurodes citri Ashmead (citrus whitefly) and Trialeurodes vaporariorum Westwood (greenhouse whitefly); Empoasca fabae Harris (potato leafhopper), Laodelphax striatellus Fallen (smaller brown planthopper), Macrolestes quadrilineatus Forbes (aster leafhopper), Nephotettix cinticeps Uhler (green leafhopper), Nephotettix nigropictus Stål (rice leafhopper), Nilaparvata lugens Stål (brown planthopper), Peregrinus maidis Ashmead (corn planthopper), Sogatella furcifera Horvath (white-backed planthopper), Sogatodes orizicola Muir (rice delphacid), Typhlocyba pomaria McAtee white apple leafhopper, Erythroneoura spp. (grape leafhoppers); Magicidada septendecim Linnaeus (periodical cicada); Icerya purchasi Maskell (cottony cushion scale), Quadraspidiotus perniciosus Comstock (San Jose scale); Planococcus citri Risso (citrus mealybug); Pseudococcus spp. (other mealybug complex); Cacopsylla pyricola Foerster (pear psylla), Trioza diospyri Ashmead (persimmon psylla). These compounds also have activity on members from the order Hemiptera including: Acrosternum hilare Say (green stink bug), Anasa tristis De Geer (squash bug), Blissus leucopterus leucopterus Say (chinch bug), Corythuca gossypii Fabricius (cotton lace bug), Cyrtopeltis modesta Distant (tomato bug), Dysdercus suturellus Herrich-Schiffer (cotton stainer), Euchistus servus Say (brown stink bug), Euchistus variolarius Palisot de Beauvois (one-spotted stink bug), Graptosthetus spp. (complex of seed bugs), Leptoglossus corculus Say (leaf-footed pine seed bug), Lygus lineolaris Palisot de Beauvois (tarnished plant bug), Nezara viridula Linnaeus (southern green stink bug), Oebalus pugnax Fabricius (rice stink bug), Oncopeltus fasciatus Dallas (large milkweed bug), Pseudatomoscelis seriatus Reuter (cotton fleahopper). Other insect orders controlled by compounds of the invention include Thysanoptera (e.g., Frankliniella occidentalis Pergande (western flower thrip), Scirthothrips citri Moulton (citrus thrip), Sericothrips variabilis Beach (soybean thrip), and Thrips tabaci Lindeman (onion tbrip); and the order Coleoptera (e.g., Leptinotarsa decemlineata Say (Colorado potato beetle), Epilachna varivestis Mulsant Mexican bean beetle) and wireworms of the genera Agriotes, Athous or Limnonius).

Compounds used in accordance with this invention can also be mixed with one or more other biologically active compounds or agents including insecticides, fungicides, nematocides, bactericides, acaricides, growth regulators such as rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural utility. Thus compositions of the present invention can further comprise a biologically effective amount of at least one additional biologically active compound or agent Examples of such biologically active compounds or agents with which compounds used in accordance with this invention can be formulated are: insecticides such as abamectin, acephate, acetamiprid, avermectin, azadirachtin, azinphos-methyl, bifenthrin, binfenazate, buprofezin, carbofuran, chlorfenapyr, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl chromafenozide, clothianidin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, diflubenzuron, dimethoate, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, fenothicarb, fenoxycarb, fenpropathrin, fenproximate, fenvalerate, fipronil, flonicamid, flucythrinate, tau-fluvalinate, flufenoxuron, fonophos, halofenozide, hexaflumuron, imidacloprid, indoxacarb, isofenphos, lufenuron, malathion, metaldehyde, methamidophos, methidathion, methomyl, methoprene, methoxychlor, monocrotophos, methoxyfenozide, nithiazin, novaluron, oxamyl, parathion, parathion-methyl, permethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, pymetrozine, pyridalyl, pyriproxyfen, rotenone, spinosad, sulprofos, tebufenozide, teflubenzuron, tefluthrin, terbufos, tetrachlorvinphos, thiacloprid, thiamethoxam, thiodicarb, thiosultap-sodium, tralomethrin, trichlorfon and triflumuron; fungicides such as acibenzolar, azoxystrobin, benomyl, blasticidin-S, Bordeaux mixture (tribasic copper sulfate), bromuconazole, carpropamid, captafol, captan, carbendazim, chloroneb, chlorothalonil, copper oxychloride, copper salts, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, (S)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzmide (RH 7281), diclocymet (S-2900), diclomezine, dicloran, difenoconazole, (S)-3,5-dihydro-5-methyl-2-(methylthio)-5-phenyl-3-(phenylamino)-4H-imidazol-4-one (RP 407213), dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dodine, edifenphos, epoxiconazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fencaramid (SZX0722), fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, fluazinam, fludioxonil, flumetover (RPA 403397), fluquinconazole, flusilazole, flutolanil flutriafol, folpet, fosetyl-aluminum, furalaxyl, furametapyr (S-82658), hexaconazole, ipconazole, iprobenfos, iprodione, isoprothiolane, kasugamycin, kresoxim-methyl mancozeb, maneb, mefenoxam, mepronil, metalaxyl metconazole, metominostrobin/fenominostrobin (SSF-126), myclobutanil, neo-asozin (ferric methanearsonate), oxadixyl, penconazole, pencycuron, probenazole, prochloraz, propamocarb, propiconazole, pyrifenox, pyraclostrobin, pyrimethanil, pyroquilon, quinoxyfen, spiroxamine, sulfur, tebuconazole, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, triadimnefon, triadimenol tricyclazole, trifloxystrobin, titiconazole, validamycin and vinclozolin; nematocides such as aldicarb, oxamyl and fenamiphos; bactericides such as streptomycin; acaricides such as amitraz, chinomethionat, chlorobenzilate, cyhexatin, dicofol, dienochlor, etoxazole, fenazaquin, fenbutatin oxide, fenpropaitrin, fenpyroximate, hexythiazox, propargite, pyridaben and tebufenpyrad; and biological agents such as Bacillus thuringiensis including ssp. alzawai and kurstaki, Bacillus thuringiensis delta endotoxin, baculovirus, and entomopathogenic bacteria, virus and fungi. Compounds used in accordance with this invention and compositions thereof may be applied to plants genetically transformed to express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin). The effect of the exogenous invertebrate pest control compounds and compositions may be synergistic with the expressed toxin proteins.

A general reference for these agricultural protectants is The Pesticide Manual, 12th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 2000.

Preferred insecticides and acaricides for mixing with compounds used in accordance with this invention include pyrethroids such as cypermethrin, cyhalothrin, cyfluthrin, beta-cyfluthrin, esfenvalerate, fenvalerate and tralomethrin; carbamates such as fenothicarb, methomyl, oxamyl and thiodicarb; neonicotinoids such as clothianidin, imidacloprid and thiacloprid; neuronal sodium channel blockers such as indoxacarb; insecticidal macrocyclic lactones such as spinos ad, abamectin, avermectin and emamectin; γ-aminobutyric acid (GABA) antagonists such as endosulfan, ethiprole and fipronil; insecticidal ureas such as flufenoxuron and triflumuron; juvenile hormone mimics such as diofenolan and pyriproxyfen; pymetrozine; and amitraz. Preferred biological agents for mixing with compounds used in accordance with this invention include Bacillus thuringiensis and Bacillus thuringienisis delta endotoxin as well as naturally occurring and genetically modified viral insecticides including members of the family Baculoviridae as well as entomophagous fungi.

Most preferred mixtures include a mixture of a compound used in accordance with this invention with cyhalothrin; a mixture of a compound used in accordance with this invention with beta-cyfluthrin; a mixture of a compound used in accordance with this invention with esfenvalerate; a mixture of a compound used in accordance with this invention with methomyl; a mixture of a compound used in accordance with this invention with imidacloprid; a mixture of a compound used in accordance with this invention with thiacloprid; a mixture of a compound used in accordance with this invention with indoxacarb; a mixture of a compound used in accordance with this invention with abamectin; a mixture of a compound used in accordance with this invention with endosulfan; a mixture of a compound used in accordance with this invention with ethiprole; a mixture of a compound used in accordance with this invention with fipronil; a mixture of a compound used in accordance with this invention with flufenoxuron; a mixture of a compound used in accordance with this invention with pyriproxyfen; a mixture of a compound used in accordance with this invention with pymetrozine; a mixture of a compound used in accordance with this invention with amitraz; a mixture of a compound used in accordance with this invention with Bacillus thuringiensis and a mixture of a compound used in accordance with this invention with Bacillus thuringiensis delta endotoxin.

In certain instances, combinations with other invertebrate pest control compounds or agents having a similar spectrum of control but a different mode of action will be particularly advantageous for resistance management. Thus, compositions of the present invention can further comprise a biologically effective amount of at least one additional invertebrate pest control compound or agent having a similar spectrum of control but a different mode of action. Contacting a plant genetically modified to express a plant protection compound (e.g., protein) or the locus of the plant with a biologically effective amount of a compound of invention can also provide a broader spectrum of plant protection and be advantageous for resistance management.

Invertebrate pests are controlled in agronomic and nonagronomic applications by applying one or more of the compounds used in accordance with this invention, in an effective amount, to the environment of the pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. Thus, the present invention finther comprises a method for the control of invertebrates in agronomic and/or nonagronomic applications, comprising contacting the invertebrates or their environment with a biologically effective amount of one or more of the compounds of the invention, or with a composition comprising at least one such compound or a composition comprising at least one such compound and an effective amount of at least one additional biologically active compound or agent. Examples of suitable compositions comprising a compound of the invention and an effective amount of at least one additional biologically active compound or agent include granular compositions wherein the additional biologically active compound is present on the same granule as the compound of the invention or on granules separate from those of the compound used in accordance with this invention.

A preferred method of contact is by spraying. Alternatively, a granular composition comprising a compound of the invention can be applied to the plant foliage or the soil. Compounds used in accordance with this invention are also effectively delivered through plant uptake by contacting the plant with a composition comprising a compound used in accordance with this invention applied as a soil drench of a liquid formulation, a granular formulation to the soil, a nursery box treatment or a dip of transplants. Compounds are also effective by topical application of a composition comprising a compound used in accordance with this invention to the locus of infestation. Other methods of contact include application of a compound or a composition of the invention by direct and residual sprays, aerial sprays, gels, seed coatings, microencapsulations, systemic uptake, baits, eartags, boluses, foggers, fumigants, aerosols, dusts and many others. The compounds used in accordance with this invention may also be impregnated into materials for fabricating invertebrate control devices (e.g. insect netting).

The compounds used in accordance with this invention can be incorporated into baits that are consumed by the invertebrates or within devices such as traps and the like. Granules or baits comprising between 0.01–5% active ingredient, 0.05–10% moisture retaining agent(s) and 40–99% vegetable flour are effective in controlling soil insects at very low application rates, particularly at doses of active ingredient that are lethal by ingestion rather than by direct contact

The compounds used in accordance with this invention can be applied in their pure state, but most often application will be of a formulation comprising one or more compounds with suitable carriers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. A preferred method of application involves spraying a water dispersion or refined oil solution of the compounds. Combinations with spray oils, spray oil concentrations, spreader stickers, adjuvants, other solvents, and synergists such as piperonyl butoxide often enhance compound efficacy.

The rate of application required for effective control (i.e. “biologically effective amount”) will depend on such factors as the species of invertebrate to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, and the like. Under normal circumstances, application rates of about 0.01 to 2 kg of active ingredient per hectare are sufficient to control pests in agronomic ecosystems, but as little as 0.0001 kg/hectare may be sufficient or as much as 8 kg/hectare may be required. For nonagronomic applications, effective use rates will range from about 1.0 to 50 mg/square meter but as little as 0.1 mg/square meter may be sufficient or as much as 150 mg/square meter may be required. One skilled in the art can easily determine the biologically effective amount necessary for the desired level of invertebrate pest control.

The following Tests in the Biological Examples of the Invention demonstrate the efficacy of methods of the invention for protecting plants from specific invertebrate pests. “Control efficacy” represents inhibition of invertebrate development (including mortality) that causes significantly reduced feeding. The pest control protection afforded by the compounds is not limited, however, to these species. See Index Tables A through D for compound descriptions. The following abbreviations are used in the Index Tables that follow: i is iso, Me is methyl, Ph is phenyl and Pr is propyl (accordingly i-Pr is isopropyl). In Index Tables B and C, the moiety R¹–R² is listed such that the left end of the moiety is attached at the R¹ location and the right end of the moiety is attached at the R² location. The abbreviation “Ex.” stands for “Example” and is followed by a number indicating in which example the compound is prepared.

INDEX TABLE A

Compound R^(4b) R² R⁵ V m.p. (° C.) 1 H CH(Me)CH₂Cl CF₃ CH 129–131 2 H i-Pr CF₃ CH 133–135 (Ex. 2) 3 H Me CF₃ CH 158–163 (Ex. 1) 4 H i-Pr CF₃ N 175–176 5 Br i-Pr CF₃ N 173–174 6 Br propargyl CF₃ N 187–190 7 Cl i-Pr Br N 207–209 8 Cl Me Br N 234–236 9 Cl i-Pr CF₃ N 165–166 10  Cl Me CF₃ N 181–182 11  Cl i-Pr Cl N 182–183 12  Cl i-Pr Br N 174–175

INDEX TABLE B

Com- pound R^(4a) R^(4b) R¹—R² R⁵ V m.p. (° C.) 13 Cl Cl —CH₂CH₂— CF₃ N * (Ex. 3) 14 Cl Cl —CH₂CH₂C(═O)— CF₃ N * 15 Cl Cl —CH═C(CH₃)— CF₃ N * 16 Cl Cl —C(CH₃)═CH— CF₃ N * *See Index Table D for ¹H NMR Data

INDEX TABLE C

Compound R^(4a) R^(4b) R¹—R² J m.p. (° C.) 17 H H —CH₂CH₂— 2,4-Cl₂—Ph 18 H H —CH═N— 3-Me—Ph 19 H H —CH═N— 4-Cl—Ph

INDEX TABLE D Compd. No. ¹HNMR Data (CDCl₃ solution unless indicated otherwise)^(a) 13 δ 8.4 (d, 1H), 7.9 (m, 2H), 7.45 (d, 1H), 7.4 (dd, 1H), 7.1 (s, 1H), 4.4 (m, 2H), 4.3–4.2 (m, 2H). 14 δ 8.5–8.4 (d, 1H), 8.4–8.3 (dd, 1H), 8.0–7.9 (dd, 1H), 7.6–7.5 (d, 1H), 7.4 (m, 2H), 7.09 (s, 1H), 4.52 (t, 2H), 2.78 (t, 2H), 2.13 (s, 3H). 15 δ 8.41 (d, 1H), 8.39 (dd, 1H), 7.90 (dd, 1H), 7.81 (q, 1H), 7.59 (d, 1H), 7.46 (s, 1H), 7.41 (dd, 1H), 2.57 (d, 3H). 16 δ 8.42 (d, 1H), 8.09 (dd, 1H), 7.90 (dd, 1H), 7.62 (d, 1H), 7.46 (m, 1H), 7.27 (dd, 1H), 7.05 (s, 1H), 2.33 (d, 3H).

BIOLOGICAL EXAMPLES OF THE INVENTION Test A

For evaluating control of diamondback moth (Plutella xylostella) the test unit consisted of a small open container with a 12–14-day-old radish plant inside. This was pre-infested with 10–15 neonate larvae on a piece of insect diet by use of a core sampler to remove a plug from a sheet of hardened insect diet having many larvae growing on it and transfer the plug containing larvae and diet to the test unit. The larvae moved onto the test plant as the diet plug dried out.

Test compounds were formulated using a solution containing 10% acetone, 90% water and 300 ppm X-770 Spreader Lo-Foam Formula non-ionic surfactant containing alkylarylpolyoxyethylene, free fatty acids, glycols and isopropanol (Loveland Industries, Inc.), unless otherwise indicated. The formulated compounds were applied in 1 mL of liquid through a SUJ2 atomizer nozzle with ⅛ JJ custom body (Spraying Systems Co.) positioned 1.27 cm (0.5 inches) above the top of each test unit. All experimental compounds in this screen were sprayed at 250 ppm (or less) and replicated three times. After spraying of the formulated test compound, each test unit was allowed to dry for 1 hour and then a black, screened cap was placed on top. The test units were held for 6 days in a growth chamber at 25° C. and 70% relative humidity. Plant feeding damage was then visually assessed.

Of the compounds tested, the following provided very good levels of plant protection (20% or less feeding damage) at the rates tested: 1*, 2*, 3*, 4*, 5*, 6*, 7**, 8**, 9**, 10**, 11**, 12**, 13**, 14.

Test B

For evaluating control of fall armyworm (Spodoptera frugiperda) the test unit consisted of a small open container with a 4–5-day-old corn (maize) plant inside. This was pre-infested with 10–15 1-day-old larvae on a piece of insect diet by use of a core sampler as described for Test A.

Test compounds were formulated and sprayed at 250 ppm (or less) as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.

Of the compounds tested, the following provided very good levels of plant protection (20% or less feeding damage) at the rates tested: 1*, 2*, 3*, 4*, 5*, 6*, 7**, 8**, 9**, 10**, 11**, 12**, 13.

Test C

For evaluating control of tobacco budworm (Heliothis virescens) the test unit consisted of a small open container with a 6–7 day old cotton plant inside. This was pre-infested with 8 2-day-old larvae on a piece of insect diet by use of a core sampler as described for Test A.

Test compounds were formulated and sprayed at 250 ppm (or less) as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.

Of the compounds tested, the following provided very good levels of plant protection (20% or less feeding damage) at the rates tested: 1*, 2*, 3*, 4*, 5*, 6*, 7**, 8**, 9**, 10**, 11**, 12**.

Test D

For evaluating control of beet armyworm (Spodoptera exigua) the test unit consisted of a small open container with a 4–5-day-old corn (maize) plant inside. This was pre-infested with 10–15 1-day-old larvae on a piece of insect diet by use of a core sampler as described for Test A.

Test compounds were formulated and sprayed at 250 ppm (or less) as described for Test A. The applications were replicated three times. After spraying, the test units were maintained in a growth chamber and then visually rated as described for Test A.

Of the compounds tested, the following provided very good levels of plant protection (20% or less feeding damage) at the rates tested: 1*, 2*, 3*, 4*, 5*, 6*, 7**, 8**, 9**, 10**, 11**, 12**.

-   * Tested at 50 ppm; ** Tested at 10 ppm. 

1. A compound of Formula Is or an N-oxide or a salt thereof

wherein B is O; J is selected from the group consisting of J-6, J-7, J-8, J-9, J-10, J-11, J-12 and J-13

V is N, GH, CF, CCL, CBr or CI; R² is H; G; C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl, C₃–C₆ cycloalkyl, each optionally substituted with one or more substituents selected from the group consisting of halogen, G, CN, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₂–C₆ alkoxycarbonyl, C₂–C₆ alkylcarbonyl, C₃–C₆ trialkylsilyl, and a phenyl, phenoxy or 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R⁶; hydroxy; C₁–C₄ alkoxy; C₁–C₄ alkylamino; C₂–C₈ dialkylamino; C₃–C₆ cycloalkylamino; C₂–C₆ alkoxycarbonyl and C₂–C₆ alkylcarbonyl; G is a 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring, optionally including one or two ring members selected from the group consisting of C(═O), SO and S(O)₂ and optionally substituted with 1 to 4 substituents selected from R³; each R³ is independently C₁–C₂ alkyl, halogen, CN, NO₂ or C₁–C₂ alkoxy; each R⁴ is independently H, C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, C₂–C₆ haloalkenyl, C₂–C₆ haloalkynyl, C₃–C₆ halocycloalkyl, halogen, CN, NO₂, hydroxy, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄ haloalkylthio, C₁–C₄ haloalkylsulfinyl, C₁–C₄ haloalkylsulfonyl, C₁–C₄ alkylamino, C₂–C₈ dialkylamino, C₃–C₆ cycloalkylamino, C₂–C₅ alkoxyalkyl, C₁–C₄ hydroxyalkyl, C(O)R¹⁰, CO₂R¹⁰, C(O)NR¹⁰R¹¹, NR¹⁰R¹¹, N(R¹⁰)CO₂R¹⁰ or C₃–C₆ trialkylsilyl; or each R⁴ is independently a phenyl, benzyl, phenoxy or a 5- or 6-membered heteroaromatic ring, each ring optionally substituted with one to three substituents independently selected from R⁶; R⁶ is C₁–C₆ alkyl, C₃–C₆ cycloalkyl, C₁–C₆ haloalkyl, halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄ haloalkylthio; each R^(6a) is independently H or R⁶; each R⁷ is independently C₁–C₆ alkyl, C₁–C₆ haloalkyl, halogen, CN, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy or C₁–C₄ haloalkylthio; R⁹ is C₂–C₆ alkyl, C₁–C₆ haloalkyl, C₃–C₆ alkenyl, C₃–C₆ haloalkenyl, C₃–C₆ alkynyl or C₃–C₆ haloalkenyl; R¹⁰ is C₁–C₄ alkyl or C₁–C₄ haloalkyl; R¹¹ is C₁–C₄ alkyl; and n is 1 or
 2. 2. The compound of claim 1 wherein R² is C₁–C₄ alkyl optionally substituted with halogen, CN, OCH₃ or S(O)_(p)CH₃; or CH₂C═CH; one R⁴ group is attached to the phenyl ring at the 2-position and said R⁴ is CH₃, CF₃, OCF₃, OCHF₂, S(O)_(p)CF₃, S(O)_(p)CHF₂, CN or halogen; a second R⁴ is H, F, Cl, Br, I or CF₃; R^(6a) is H, C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen or CN; R⁷ is CH₃, CF₃, OCH₂CF₃, OCHF₂ or halogen; R⁹ is C₂–C₆ alkyl or C₁–C₆ haloalkyl; and p is 0, 1 or
 2. 3. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-6; V is N or CH; and R⁷ is CH₃, CF₃, OCH₂CF₃, OCHF₂ or halogen.
 4. The compound of claim 3 wherein R^(6a) is F, Cl or Br; and R⁷ is halogen or CF₃.
 5. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-7.
 6. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-8; V is N; R⁶ is Cl or Br; and R⁷ is halogen or CF₃.
 7. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-9; R^(6a) is Cl or Br; and R⁷ is CF₃.
 8. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-10; R^(6a) is Cl or Br; and R⁹ is CH₂CF₃, CHF₂ or CF₃.
 9. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-11; R^(6a) is Cl or Br; and R⁷ is halogen, OCH₂CF₃, OCHF₂ or CF₃.
 10. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-12; R^(6a) is Cl or Br, R⁷ halogen; OCH₂CF₃; and R⁹ is CH₂CF₃, CHF₂ or CF₃.
 11. The compound of claim 2 wherein J substituted with 1 to 3 R⁵ is J-13; R^(6a) is Cl or Br; and R⁹ is CH₂CF₃, CHF₂ or CF₃.
 12. The compound of claim 3 selected from the group consisting of: N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine, N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazinylidene]-2-propanamine, N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine, N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]methanamine, N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine, N-[6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]ethanamine, N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3, 1-benzoxazin-4-ylidene]methanamine, N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3, 1-benzoxazin-4-ylidene]-2-propanamine, N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3, 1-benzoxazin-4-ylidene]ethanamine, N-[6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine, N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine, N-[2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine, N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-propanamine and N-[2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-ylidene]-2-methyl-2-propanamine.
 13. A composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula Is of claim 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, said composition optionally further comprising an effective amount of at least one additional biologically active compound or agent.
 14. The compound of claim 1 wherein R² is H or C₁–C₆ alkyl, C₂–C₆ alkenyl, C₂–C₆ alkynyl or C₃–C₆ cycloalkyl each optionally substituted with one or more substituents selected from the group consisting of halogen, CN, C₁–C₂ alkoxy, C₁–C₂ alkylthio, C₁–C₂ alkylsulfinyl and C₁–C₂ alkylsulfonyl; and one R⁴ group is attached to the phenyl ring at the 2-position or 5-position, and said R⁴ is C₁–C₄ alkyl, C₁–C₄ haloalkyl, halogen, CN, NO₂, C₁–C₄ alkoxy, C₁–C₄ haloalkoxy, C₁–C₄ alkylthio, C₁–C₄ alkylsulfinyl, C₁–C₄ alkylsulfonyl, C₁–C₄ haloalkylthio, C₁–C₄ haloalkylsulfinyl or C₁–C₄ haloalkylsulfonyl. 